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| 1 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 2 | Colorectal Cancer: National and International Perspective on the Burden of Disease and Public Health Impact显示文摘 | Ziad F. Gellad Dawn Provenzale | 2010 | Gastroenterology2010，，6： | 1 |
| 3 | Bilateral congenital voeal cord paralysis: a 16-year institutional review显示文摘 | Miyamoto RC Parikh SR Gellad W | 2005 | Otolaryn- gol Head Neck Surg2005，133，2： | 1 |
| 4 | Vascular metastatic le-sions of the spine : peroprative embolization显示文摘 | Gellad FE Sadato N Numaguchi Y | 1990 | Radiology1990，176，3： | 1 |
| 5 | Colorectal cancer: National and international perspective on the burden of disease and public health impact 显示文摘 | Gellad Z F Provenzale D | 2010 | Gastroenterology2010，138，6： | 1 |
| 6 | Vascular metastatic lesion of the spine:preoperative embolization显示文摘 | Gellad FM Sadato N Numaguchi Y | 1990 | Radiology1990，176，： | 1 |
| 7 | Vascular metastatic lesions of the spine: preoperative embolization显示文摘 | Gellad FE Sadato N Numufnchi Y | 1990 | Radiology1990，176，3： | 1 |
| 8 | Vascular metastatic 1 esions of the spine:preoperative embolization显示文摘 | Gellad FE Sadato N Numaguchi Y | 1990 | Radiology1990，176，3： | 1 |
| 9 | What if the Federal Government Negotiated Pharmaceutical Prices for Seniors? An Estimate of National Savings显示文摘 | Walid F. Gellad Sebastian Schneeweiss Phyllis Brawarsky Stuart Lipsitz Jennifer S. Haas | 2008 | Journal of General Internal Medicine2008，，： | 1 |
| 10 | Vascular metastatic lesions of the spine: preoperative embolization 显示文摘 | Gellad FE Sadato N Nmnaguchi Y | 1990 | Radiology1990，176，3： | 1 |
| 11 | Colorectal cancer:national and interna- tional perspective on the burden of disease and public health im- pact 显示文摘 | Gellad ZF Provenzale D | 2010 | Gastroenterology2010，138，6： | 1 |
| 12 | Vascular metastatie lesions of the spine: preoperative embolization显示文摘 | Gellad FE Sadato N Numaguehi Y | 1990 | Radiology1990，176，： | 1 |
| 13 | Vascular metastatic lesions of the spine: preoperative embolization 显示文摘 | Gellad FE Sadato N Numaguehi Y | 1990 | Radiology1990，176，3： | 1 |
| 14 | Vascular metastatic 1 esions of the spine: preoperative embolization显示文摘 | Gellad FE Sadato N Numaguehi Y | 1990 | Radiology1990，176，3： | 1 |
| 15 | Vascular metastatic lesions of the spine:preoperative embolization显示文摘 | Gellad FE Sadato N Numufnchi Y | 1990 | Radiology1990，176，3： | 1 |
| 16 | Vascular metastatic lesions of the spine: preoperative embolization显示文摘 | Sadato N Numaguchi Y | 1990 | Radiology1990，176，： | 1 |
| 17 | Vascular metastatic lesions of the spine:preoperative embolization显示文摘 | Gellad FE Sadato N Numaguchi Y | | 0，，03： | 1 |
| 18 | Vascular metastatic lesions of the spine:preoperative embolization显示文摘 | Gellad FE Sadato N Numufnchi Y | 1990 | Radiology1990，176，： | 1 |
| 19 | Vascular metastatic lesions of the spine:preoperative embolization显示文摘 | Gellad FE Sadato N Numufnchi Y | 1990 | Radiology1990，176，： | 1 |
| 20 | Vascular metastatic lesions of the spine : preoperative embolization 显示文摘 | Gellad FE Sadato N Numaguehi Y | 1990 | Radiology1990，176，： | 1 |
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