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| 1 | Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites显示文摘AIM To assess the relationship between the presence of toll-like receptor 4(TLR4) polymorphisms and bacterial infections in cirrhotic patients with ascites. METHODS We prospectively included consecutive patients with cirrhosis and ascites hospitalized during a 6-year period. Patients with human immunodeficiency virus(HIV) infection or any other immunodeficiency, patients with advanced hepatocellular carcinoma(beyond Milan's criteria) or any other condition determining poor short-term prognosis, and patients with a permanent urinary catheter were excluded. The presence of D299 G and/or T399 I TLR4 polymorphisms was determined by sequencing and related to the incidence and probability of bacterial infections, other complications of cirrhosis, hepatocellular carcinoma, and mortality during follow-up. A multivariate analysis to identify predictive variables of mortality in the whole series was performed. RESULTS We included 258 patients: 28(10.8%) were carriers of D299G and/or T399I TLR4 polymorphisms(polymorphism group) and 230 patients were not(wildtype group). The probability of developing any bacterial infection at one-year follow-up was 78% in the polymorphism group and 69% in the wild-type group(P = 0.54). The one-year probability of presenting infections caused by gram-negative bacilli(51% vs 44%, P = 0.68), infections caused by gram-positive cocci(49% vs 40%, P = 0.53), and spontaneous bacterial peritonitis(29% vs 34%, respectively, P = 0.99) did not differ between the two groups. The oneyear probability of transplant-free survival was 55% in the polymorphism group and 66% in the wild-type group(P = 0.15). Multivariate analysis confirmed that age, Child-Pugh score, active alcohol intake, previous hepatic encephalopathy, hepatocellular carcinoma and serum creatinine were associated with a higher risk of death during follow-up. CONCLUSION Genetic polymorphisms D299 G and/or T399 I of TLR4 do not seem to play a relevant role in the predisposition of cirrhotic patients with ascites to bacterial infections. | Edilmar Alvarado-Tapias Carlos Guarner-Argente Elida Oblitas Elisabet Sánchez Silvia Vidal Eva Román Mar Concepción Maria Poca Cristina Gely Oana Pavel Juan Camilo Nieto Cándido Juárez Carlos Guarner Germán Soriano | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 2 | Dynamic load balancing by diffusion in heterogeneous systems显示文摘 | Rotaru T and N~geli H | 2004 | Journal of Parallel and Distributed Computing2004，64，4： | 1 |
| 3 | Methylation of the pl6INKgA promoter is associated with malignant behavior in abdominal extra- adrenal paragangliomas but not pheochromocytomas 显示文摘 | Kiss N Geli J Lundberg F | 2008 | Endocr Relat Cancer2008，15，2： | 1 |
| 4 | Progesterone regulates ILl2 expression in pregnancy lymphocytes by inhibiting pbospholipase A2 显示文摘 | Par G Geli J Kozma N | 2003 | Am J Reprod Immunol2003，49，1： | 1 |
| 5 | Progesterone Regulates IL/2 Expression in pregnancy Lymphocytes by Inhibiting phospholipase A2 显示文摘 | Par G Geli J Kozma N | 2008 | Am J Reprod Immunol2008，49，1： | 1 |
| 6 | ProgesteroneRegulates IL/2 Expres- sion in pregnancy Lymphocytes by Inhibiting phospholipase A2 显示文摘 | Par G Geli J Kozma N | 2008 | Am J Reprod Immunol2008，49，1： | 1 |
| 7 | Tuning the affinity for lanthanides of calcium binding proteins显示文摘 | Bertini I Gelis I Katsaros N | 2003 | Biochemistry2003，42，26： | 1 |
| 8 | How to discriminate contamination from bloodstream infection due to coagulase-negative staphylococci:a prospective study with 654 patients显示文摘 | Elzi L Babouee B V(o)geli N | 2012 | Clin Microbiol Infect2012，18，9： | 1 |
| 9 | Characterization of liver lesions by real-time contrast-enhanced ultrasonography显示文摘 | Geli N Gaiani S Piscaglia F | 2007 | Eur J Gastroenterol Hepatol2007，19，1： | 1 |
| 10 | Assessment of the skin photoprotective capacities of an organo-mineral broad-spectrum sunblock on two ex vivo skin models显示文摘 | Gelis C Girard S Mavon A Delverdier M Paillous N Vicendo P | 2003 | Photodermatol Photoimmunol Photomed2003，19，5： | 1 |
| 11 | Methylation of the p16INK4a promoter is associated with malignant behavior in abdominal extra-adrenal paragangliomas but not pheochromocytomas 显示文摘 | Kiss N Geli J Larsson C | 2008 | Endocr Relat Cancer2008，15，2： | 1 |
| 12 | The Ras effectors NORE1A and RASSF1A are frequently inactivated in pheochromocytoma and abdominal paraganglioma显示文摘 | Geli J Kiss N Lanner F Foukakis T | 2007 | Endocr Relat Cancer2007，14，： | 1 |
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