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| 1 | Pulse contour analysis to assess hemodynamic response to passive leg raising显示文摘 | Geerts B De Wilde R Aarts L | 2011 | J Cardiothorac Vasc Anesth2011，25，1： | 1 |
| 2 | Fetal heart rate in chromosomally abnormal fetuses显示文摘 | Liao AW Snijders R Geerts L | | 0，，07： | 1 |
| 3 | Macrophage galac?tose-type C-type lectins as novel makers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation显示文摘 | Geert R Brys L B Brandt I | 2005 | J Leukoc Bioi2005，77，3： | 1 |
| 4 | Clinical outcomes of patients with duodenal adenocarcinoma and intestinal-type papilla of Vater adenocarcinoma显示文摘BACKGROUND Duodenal adenocarcinoma(DA)and intestinal-type papilla of Vater adenocarcinoma(it-PVA)are rare malignancies of the gastrointestinal tract.Current therapeutic options are translated nowadays from treatment strategies for patients with colorectal cancer due to histopathological similarities.AIM To retrospectively investigate the clinical outcome of patients with DA and it-PVA.METHODS All patients with DA and it-PVA diagnosed between 2000 and 2017 were included at two academic centers in the Netherlands.All patients with histopathologically-confirmed DA or it-PVA were eligible for inclusion.Clinical outcome was compared between DA and it-PVA per disease stage.In the subgroup of stage IV disease,survival after local treatment of oligometastases was compared with systemic therapy or supportive care.RESULTS In total,155 patients with DA and it-PVA were included.Patients with it-PVA more often presented with stage I disease,while DA was more often diagnosed at stage IV(P<0.001).Of all patients,79%were treated with curative intent.The median survival was 39 mo,and no difference in survival was found for patients with DA and it-PVA after stratification for disease stage.Seven(23%)of 31 patients with synchronous stage IV disease underwent resection of the primary tumor,combined with local treatment of oligometastases.Local treatment of metastases was associated with an overall survival of 37 mo,compared to 14 and 6 mo for systemic therapy and supportive care,respectively.CONCLUSION Survival of patients with DA and it-PVA is comparable per disease stage.These results suggest a potential benefit for local treatment strategies in selected patients with oligometastases,although additional prospective studies are needed. | Laura L Meijer Marin Strijker Jacob K de Bakker Jurgen GJ Toennaer Barbara M Zonderhuis Hans J van der Vliet Hanneke Wilmink Joanne Verheij Freek Daams Olivier R Busch Nicole CT van Grieken Marc G Besselink Geert Kazemier | 2020 | World Journal of Gastrointestinal Oncology2020，12，3： | 1 |
| 5 | Cure kinetics and morphology of blends of epoxy resin with poly (ether ether ketone) containing pendant tertiary butyl groups 显示文摘 | Bejoy F Geert V P Fabrice P Gabriel G V Rao L Ramaswamy R Thomas S | 2003 | Polymer2003，44，： | 1 |
| 6 | The metagenome of the marine anammox bacterium ‘Candidatus Scalindua profunda’ illustrates the versatility of this globally important nitrogen cycle bacterium 显示文摘 | Van De Vossenberg J Woebken D Maalcke WJ Wessels HJ Dutilh BE Kartal B Janssen-Megens EM Roeselers G Yan J Speth D Gloerich J Geerts W Van Der Biezen E Pluk W Francoijs KJ Russ L Lam P Malfatti SA Tringe SG Haaijer SC Op Den Camp HJ Stunnenberg HG Amann R Kuypers MM Jetten MS | 2013 | Environ Microbiol2013，15，5： | 1 |
| 7 | Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well:results from the MR CLEAN Registry显示文摘Background Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment(EVT)for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen well.However,outcomes after EVT in these late window patients without perfusion imaging are largely unknown.We assessed their characteristics and outcomes in routine clinical practice.Methods The Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry,a prospective,multicentre study in the Netherlands,included patients with an anterior circulation occlusion who underwent EVT between 2014 and 2017.CT perfusion was no standard imaging modality.We used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age,prestroke modified Rankin Scale(mRS),National Institutes of Health Stroke Scale,Alberta Stroke Programme Early CT Score(ASPECTS),collateral status,location of occlusion and treatment with intravenous thrombolysis.Outcomes included 3-month mRS score,functional independence(defined as mRS 0-2),and death.Results Of 3264 patients who underwent EVT,106(3.2%)were treated beyond 6.5 hours(median 8.5,IQR 6.9-10.6),of whom 93(87.7%)had unknown time of stroke onset.CT perfusion was not performed in 87/106(80.2%)late window patients.Late window patients were younger(mean 67 vs 70 years,p<0.04)and had slightly lower ASPECTS(median 8 vs 9,p<0.01),but better collateral status(collateral score 2-3:68.3%vs 57.7%,p=0.03).No differences were observed in proportions of functional independence(43.3%vs 40.5%,p=0.57)or death(24.0%vs 28.9%,p=0.28).After matching,outcomes remained similar(adjusted common OR for 1 point improvement in mRS 1.04,95%CI 0.56 to 1.93).Conclusions Without the use of CT perfusion selection criteria,EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/CT angiography characteristics.randomised controlled trials with lenient inclusion criteria are needed to identify more patients who can benefit from EVT in the late window. | Luuk Dekker Esmee Venema F Anne V Pirson Charles B L M Majoie Bart J Emmer Ivo G H Jansen Maxim J H L Mulder Robin Lemmens Robert-Jan B Goldhoorn Marieke J H Wermer Jelis Boiten Geert J LycklamaàNijeholt Yvo B W E M Roos Adriaan C G M van Es Hester F Lingsma Diederik W J Dippel Wim H van Zwam Robert J van Oostenbrugge Ido R van den Wijngaard on behalf of the MR CLEAN Registry investigators | 2021 | Stroke & Vascular Neurology2021，6，4： | 1 |
| 8 | Block Transmissions over Doubly-Selective Channels:Iterntive Channel Estimation and Turbo Equalization显示文摘 | Kun F Luca R Geert L | 2010 | EURASIP Journal on Advances in signal Processing2010，，4： | 1 |
| 9 | Estimation and equalization of doubly selective channels using known symbol padding 显示文摘 | OLIVIER R GEERT L MARC M | 2006 | IEEE Transactions on Signal Processing2006，54，3： | 1 |
| 10 | The metagenome of the marine anammox bacterium 'Candidatus Scalinduaprofunda' illustrates the versatility of this globally important nitrogen cycle bacterium 显示文摘 | van de Vossenberg J Woebken D Maalcke WJ Wessels HJ Dutilh BE Kartal B Janssen-Megens EM Roeselers K Yan J Speth D Gloericb J Geerts W van der Biezen E Pluk W Francoijs KJ Russ L Lain P Malfatti SA Tringe SG Haaijer SC Op den Camp HJ Stunnenberg HG Amann R Kuypers MM Jetten MS | 2012 | Environ Microbiol2012，15，5： | 1 |
| 11 | Simple equalization of time- varying channels for OFDM 显示文摘 | Luca R Paolo B Geert L | 2005 | IEEE Communications Letters2005，9，7： | 1 |
| 12 | Ultrastructure of the denitrifying methanotroph ' Candidatus Methylomirabilis oxyfera,' a novel polygon-shaped bacterium显示文摘 | Wu ML van Teeseling MC Willems M J van Donselaar EG Klingl A Rachel R Geerts WJ Jetten MS Strous M van Niftrik L | | 0，，2： | 1 |
| 13 | Hepatitis C virus envelope proteins: immunogenicity in humans and their role in diagnosis and vaccine development显示文摘 | Geert L R | 1995 | J Viral Hep1995，5，： | 1 |
| 14 | Intra-arterial thrombolytics during endovascular thrombectomy for acute ischaemic stroke in the MR CLEAN Registry显示文摘Introduction The efficacy and safety of local intra-arterial(IA)thrombolytics during endovascular thrombectomy(EVT)for large-vessel occlusions is uncertain.We analysed how often IA thrombolytics were administered in the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands(MR CLEAN)Registry,whether it was associated with improved functional outcome and assessed technical and safety outcomes compared with EVT without IA thrombolytics.Methods In this observational study,we included patients undergoing EVT for an acute ischaemic stroke in the anterior circulation from the MR CLEAN Registry(March 2014-November 2017).The primary endpoint was favourable functional outcome,defined as an modified Rankin Scale score≤2 at 90 days.Secondary endpoints were reperfusion status,early neurological recovery and symptomatic intracranial haemorrhage(sICH).Subgroup analyses for IA thrombolytics as primary versus adjuvant revascularisation attempt were performed.Results Of the 2263 included patients,95(4.2%)received IA thrombolytics during EVT.The IA thrombolytics administered were urokinase(median dose,250000 IU(IQR,193750-250000))or alteplase(median dose,20 mg(IQR,12-20)).No association was found between IA thrombolytics and favourable functional outcome(adjusted OR(aOR),1.16;95%CI 0.71 to 1.90).Successful reperfusion was less often observed in those patients treated with IA thrombolytics(aOR,0.57;95%CI 0.36 to 0.90).The odds of sICH(aOR,0.82;95%CI 0.32 to 2.10)and early neurological recovery were comparable between patients treated with and without IA thrombolytics.For primary and adjuvant revascularisation attempts,IA thrombolytics were more often administered for proximal than for distal occlusions.Functional outcomes were comparable for patients receiving IA thrombolytics as a primary versus adjuvant revascularisation attempt.Conclusion Local IA thrombolytics were rarely used in the MR CLEAN Registry.In the relatively small study sample,no statistical difference was observed between groups in the rate of favourable functional outcome or sICH.Patients whom required and underwent IA thrombolytics were patients less likely to achieve successful reperfusion,probably due to selection bias. | Sabine L Collette Reinoud P H Bokkers Aryan Mazuri Geert J LycklamaàNijeholt Robert J van Oostenbrugge Natalie E LeCouffe Faysal Benali Charles B L M Majoie Jan Cees de Groot Gert Jan R Luijckx Maarten Uyttenboogaart 无 | 2023 | Stroke & Vascular Neurology2023，8，1： | 0 |
| 15 | Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis显示文摘AIM: To investigate if azathioprine could reduce adenoma formation in ApcMin/+, a mouse model of sporadic intestinal tumorigenesis.METHODS:Azathioprine was administered via drinking water(estimated 6-20 mg/kg body weight per day)to ApcMin/+and wildtype mice.Control animals received vehicle only(DMSO)dissolved in drinking water.At 15wk of age all mice were sacrificed and intestines of ApcMin/+were harvested for evaluation of polyp number.Azathioprine induced toxicity was investigated by immunohistochemical analysis on spleens.RESULTS:All azathioprine treated mice showed signs of drug-associated toxicity such as weight loss and development of splenic T-cell lymphomas.Although this suggests that the thiopurine concentration was clearly in the therapeutic range,it did not reduce tumor formation(48±3.1 adenomas vs 59±5.7 adenomas,P=0.148).CONCLUSION:We conclude that in the absence of inflammation,azathioprine does not affect intestinal tumorigenesis. | Mattheus CB Wielenga Jooske F van Lidth de Jeude Sanne L Rosekrans Alon D Levin Monique Schukking Geert RAM D'Haens Jarom Heijmans Marnix Jansen Vanesa Muncan Gijs R van den Brink | 2014 | World Journal of Gastroenterology2014，20，44： | 0 |
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