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| 1 | Application of cationic liposomes for delivery of nucleic acids显示文摘Nucleic acid-based bioactive substances have recently emerged as a new class of nextgeneration therapeutics, but their development has been limited by their relatively weakdelivery into target cells. Cationic liposomes have been studied as a means to enhance thestability of nucleic acid therapeutics in the bloodstream and improve their cellular delivery.As nucleic acid therapeutics, siRNA and plasmid DNA have been extensively tested fordelivery using cationic liposomes. This review discusses recent progress in the applicationof cationic liposomes for the delivery of nucleic acid therapeutics. | Gayong Shim Mi-Gyeong Kim Joo Yeon Park Yu-Kyoung Oh | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，2： | 5 |
| 2 | Therapeutic gene editing: delivery and regulatory perspectives显示文摘 | Gayong SHIM Dongyoon KIM Gyu Thae PARK Hyerim JIN Soo-Kyung SUH Yu-Kyoung OH | 2017 | Acta Pharmacologica Sinica2017，38，6： | 3 |
| 3 | Claudin 4-targeted nanographene phototherapy using a Clostridium perfringens enterotoxin peptidephotosensitizer conjugate显示文摘 | Gayong SHIM Mi-Gyeong KIM Hyerim JIN Jinyoung KIM Yu-Kyoung OH | 2017 | Acta Pharmacologica Sinica2017，38，6： | 2 |
| 4 | Surface-modified liposomes for syndecan 2-targeted delivery of edelfosine显示文摘Here, we report that the modification of liposome surfaces with AG73 peptides enhances delivery of the lipophilic anticancer drug, edelfosine, to tumor cells overexpressing the cellsurface receptor, syndecan 2. To test the effect of liposomal surface density of AG73 peptides on cellular uptake, we synthesized AG73 peptide-conjugated polyethylene glycol(MW 2000)lipid and incorporated it into fluorescence dye-labeled anionic liposomes with different ligand densities(1, 2, or 5 mol% of total lipids). Cellular uptake of AG73-peptide–modified liposomes gradually increased in proportion to the surface ligand density. The percentages of cells positive for AG73-modified, fluorescent-dye–labeled liposomes were 19.8 ± 2.0%, 23.1 ± 5.0%,and 99.2 ± 1.0%, for ligand mole percentages of 1, 2, and 5, respectively. The cell-targeting ability of AG73-modified liposomes was not significantly altered by the serum content of culture media. In keeping with the observed enhanced cellular uptake, AG73-peptide–modified liposomes entrapping edelfosine exhibited greater cancer cell-killing effects compared with unmodified liposomes. Following intravenous administration into tumor-bearing mice,AG73-peptide–modified liposomes showed 2.1-fold greater accumulation in tumors than unmodified liposomes. These results support the feasibility of using syndecan 2–directed liposomes for delivery of edelfosine. | Gayong Shim Yong Hee Yu Soondong Lee Jinyoung Kim Yu-Kyoung Oh | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 1 |
| 5 | Safety and tumor tissue accumulation of pegylated graphene oxide nanosheets for co-delivery of anticancer drug and photosensitizer显示文摘 | Wenjun Miao Gayong Shim Sangbin Lee Soondong Lee Yearn Seong Choe Yu-Kyoung Oh | 2013 | Biomaterials2013，，13： | 1 |
| 6 | Nanotechnology and vaccine development显示文摘Despite the progress of conventional vaccines,improvements are clearly required due to concerns about the weak immunogenicity of these vaccines,intrinsic instability in vivo,toxicity,and the need for multiple administrations.To overcome such problems,nanotechnology platforms have recently been incorporated into vaccine development.Nanocarrier-based delivery systems offer an opportunity to enhance the humoral and cellular immune responses.This advantage is attributable to the nanoscale particle size,which facilitates uptake by phagocytic cells,the gut-associated lymphoid tissue,and the mucosa-associated lymphoid tissue,leading to efficient antigen recognition and presentation.Modifying the surfaces of nanocarriers with a variety of targeting moieties permits the delivery of antigens to specific cell surface receptors,thereby stimulating specific and selective immune responses.In this review,we introduce recent advances in nanocarrierbased vaccine delivery systems,with a focus on the types of carriers,including liposomes,emulsions,polymer-based particles,and carbon-based nanomaterials.We describe the remaining challenges and possible breakthroughs,including the development of needlefree nanotechnologies and a fundamental understanding of the in vivo behavior and stability of the nanocarriers in nanotechnology-based delivery systems. | Mi-Gyeong Kim Joo Yeon Park Yuna Shon Gunwoo Kim Gayong Shim Yu-Kyoung Oh | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，5： | 1 |
| 7 | DNA-based artificial dendritic cells for in situ cytotoxic T cell stimulation and immunotherapy显示文摘In immunotherapy,ex vivo stimulation of T cells requires significant resources and effort.Here,we report artificial dendritic cell-mimicking DNA microflowers(DM)for programming T cell stimulation in situ.To mimic dendritic cells,DNA-based artificial dendritic microflowers were constructed,surface-coated with polydopamine,and further modified with anti-CD3 and anti-CD28 antibodies to yield antibody-modified DM(DM-A).The porous structure of DM-A allowed entrapment of the T cell-stimulating cytokine,ineterleukin-2,yielding interleukin-2-loaded DM-A(DM-AI).For comparison,polystyrene microparticles coated with polydopamine and modified with anti-CD3 and anti-CD28 antibodies(PS-A)were used.Compared to PS-A,DM-AI showed significantly greater contact with T cell surfaces.DM-AI provided the highest ex vivo expansion of cytotoxic T cells.Local injection of DM-AI to tumor tissues induced the recruitment of T cells and expansion of cytotoxic T cells in tumor microenvironments.Unlike the other groups,model animals injected with DM-AI did not exhibit growth of primary tumors.Treatment of mice with DM-AI also protected against growth of a rechallenged distant tumor,and thus prevented tumor recurrence in this model.DM-AI has great potential for programmed stimulation of CD8+T cells.This concept could be broadly extended for the programming of specific T cell stimulation profiles. | Quoc-Viet Le Jaiwoo Lee Junho Byun Gayong Shim Yu-Kyoung Oh | 2022 | Bioactive Materials2022，7，9： | 0 |
| 8 | Chemokine-mimetic plerixafor derivative for tumorspecific delivery of nanomaterials显示文摘这里,我们报导 chemokine 模仿的 plerixafor 衍生物能管理肿瘤特定的交货和 nanomaterials 的功能的效果。减少的 graphene 氧化物(rGO ) nanosheets 被用作一个模型功能的 nanomaterial,和结合 plerixafor 的类脂化合物或结合 plerixafor 的类脂化合物(BPL/rGO ) 的 benzylcyclam 衍生物(PL/rGO ) 身体上被吸附到 rGO 的表面上。修改表面的 rGO 的细胞的举起依赖于癌症房间上的 CXCR4 chemokine 受体的 overexpression。在 KB 房间,为 CXCR4 的 BPL/rGO 的有约束力的亲密关系是比 PL/rGO 的大的 6.8 褶层。尤其是,细胞的举起模式相关与在 vitro photothermal anticancer 功效。BPL/rGO 的肿瘤分发在忍受 CXCR4-overexpressing 肿瘤的老鼠比 PL/rGO 和平凡 rGO 的高,而各种各样的 rGO 形式的分发在怀有 CXCR4 否定的肿瘤的老鼠是类似的。而且,完全的 photothermal 肿瘤脱离在忍受 CXCR4 积极的 KB 房间肿瘤的 BPL/rGO-treated 老鼠,然而并非在 CXCR4 否定的 MCF-7 房间肿瘤被观察。这些结果提供 BPL 能被用来提高 nanomaterials 的交货到 CXCR4-overexpressing 肿瘤的证据。Chemokine 模仿的 BPL 能进一步被申请 photosensitizers, anticancer 药,或在 CXCR4-overexpressing 癌症病人的诊断肿瘤成像代理人的基于 nanomaterial 的交货。 | Seungbeom Ko Gayong Shim Jinyoung Kim Yu-Kyoung Oh | 2018 | Nano Research2018，11，4： | 0 |
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