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| 1 | Teaching evidence based practice and research through blended learning to under~adu- ate midwifery students from a practice based perspective 显示文摘 | Sidebotham Mary Jomeen Julie Gamble Jennifer | 2014 | Nurse Education in Practice2014，，14： | 1 |
| 2 | Teaching evi-dence based practice and research through blended learning to un-dergraduate midwifery students from a practice based perspective显示文摘 | Sidebotham Mary Jomeen Julie Gamble Jennifer | 2014 | Nurse Education in Practice2014，14，： | 1 |
| 3 | The role of sphingosine kinase 1 in cancer: Oncogene or non-oncogene addiction?显示文摘 | Mathew Vadas Pu Xia Geoff McCaughan Jennifer Gamble | 2008 | BBA - Molecular and Cell Biology of Lipids2008，，9： | 1 |
| 4 | Transverse dental changes after tooth-borne and bone-borne maxillary expansion显示文摘 | Manuel O. Lagravère Jennifer Gamble Paul W. Major Giseon Heo | 2012 | International Orthodontics2012，，： | 1 |
| 5 | Classifying and detecting anomalies in hybrid Knowledge-Based systems 显示文摘 | Mukherjee Ranadeep Gamble Rose F Parkinson Jennifer A | 1997 | Decision Support Systems1997，21，4： | 1 |
| 6 | Predictors of persistent detrusor overactivity after transvaginal sling procedures显示文摘 | Tondalaya L. Gamble Sylvia M. Botros Jennifer L. Beaumont Roger P. Goldberg Jay-James R. Miller Oyinlolu Adeyanju Peter K. Sand | 2008 | American Journal of Obstetrics and Gynecology2008，，6： | 1 |
| 7 | Angiogenesis: Models and Modulators显示文摘 | Gillian W. Cockerill Jennifer R. Gamble Mathew A. Vadas | 1995 | International Review of Cytology1995，，： | 1 |
| 8 | Diversity of reptile sex chromosome evolution revealed by cytogenetic and linked-read sequencing显示文摘Reptile sex determination is attracting much attention because the great diversity of sex-determination and dosage compensation mechanisms permits us to approach fundamental questions about mechanisms of sex chromosome turnover. Recent studies have made significant progress in better understanding diversity and conservation of reptile sex chromosomes, with however no reptile master sex determination genes identified. Here we describe an integrated genomics and cytogenetics pipeline,combining probes generated from the microdissected sex chromosomes with transcriptome and genome sequencing to explore the sex chromosome diversity in non-model Australian reptiles. We tested our pipeline on a turtle, two species of geckos, and a monitor lizard. Genes identified on sex chromosomes were compared to the chicken genome to identify homologous regions among the four species. We identified candidate sex determining genes within these regions, including conserved vertebrate sex-determining genes pdgfa,pdgfra amh and wt1, and demonstrated their testis or ovary-specific expression. All four species showed gene-by-gene rather than chromosome-wide dosage compensation. Our results imply that reptile sex chromosomes originated by independent acquisition of sex-determining genes on different autosomes,as well as translocations between different ancestral macro-and microchromosomes.We discuss the evolutionary drivers of the slow differentiation and turnover of reptile sex chromosomes. | Ze-Xian Zhu Kazumi Matsubara Foyez Shams Jason Dobry Erik Wapstra Tony Gamble Stephen DSarre Arthur Georges Jennifer AMarshall Graves Qi Zhou Tariq Ezaz | 2022 | Zoological Research2022，43，5： | 0 |
| 9 | Novel technologies and models for studying pharmacological activities of traditional Chinese medicine for promoting blood circulation and removing blood stasis显示文摘OBJECTIVE Our previous studies demonstrated that various ingredients from the traditional Chinese medicine(TCM)for promoting blood circulation and removing blood stasis,as exemplified by cryptotanshinone and salvianolic acid B,exerted striking effects on modulating angiogenesis and vascular permeability,which suggests that they may be effective in treating vascular leak-driven diseases(e.g.tumor,cerebral cavernous malformation and diabetic retinopathy).However,the lack of reliable and advanced technologies and models sets up difficult hurdles for better understanding the role of TCM for promoting blood circulation and removing blood stasis.To this end,this study is to outline numerous cutting-edge platforms that can be utilized for exploring the function of TCM for promoting blood circulation and removing blood stasis in vascular leak-driven diseases.METHODS Two-photon laser scanning fluorescence microscopy was used to observe the interactions between neutrophils and blood vessels in a real-time manner.Dynamic flow system was employed to mimic the in vivo behaviors of neutrophils.RIP1-Tag5 spontaneous pancreatic cancer model was used to study the function of tumor blood vessels.CCM2ECKO(deletion of CCM2 in endothelial cells)mice were employed to establish the cerebral cavernous malformation(CCM)animal model.Micro-computed tomography(micro-CT)was utilized to assess the CCM lesion.Müller cell-knockout mouse model was used to study the progression of diabetic retinopathy.Vascular permeability in this model was assessed by fluorescein angiography.RESULTS The interactions between neutrophils and endothelial cells involve a series of complicated processes,including rolling,adhesion,intraluminal crawling and transmigration,which were all monitored in vivo by two-photon laser scanning fluorescence microscopy in a real-time manner.Dynamic flow system was capable of recapitulating the biological behaviors of neutrophils in vitro.Tumor vascular function in particular vascular perfusion could be assessed in the RIP1-Tag5 spontaneous pancreatic cancer model.In terms of CCM studies,specific deletion of CCM2 in endothelial cells resulted in the initiation of CCM lesion.The size and number of CCM lesions could be visualized and quantified by micro-CT.Furthermore,the Müller cell-knockout mouse model was able to precisely reflect the clinical symptoms of diabetic retinopathy.Vascular leak could be monitored at different time points using fluorescein angiography.CONCLUSION An array of high technologies and animal models can be used in investigating the occurrence and progression of multiple vascular leak-driven diseases.The pre-clinical and clinical studies of TCM for promoting blood circulation and removing blood stasis provide fundamental support for the application of the above-mentioned platforms,with the purpose of uncovering the scientific basis of TCM for promoting blood circulation and removing blood stasis. | ZHAO Yang WEI Zhong-hong YU Su-yun WANG Ai-yun CHEN Wen-xing ZHENG Xiang-jian Mathew VADAS Jennifer GAMBLE LU Yin | 2021 | 中国药理学与毒理学杂志2021，35，10： | 0 |
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