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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Local invasion of gastric cancer:CT findings and pathologic correlation using 5-mm incremental scanning,hypotonia,and water-filling显示文摘 | Rossi M Broglia L Graziano P | 1999 | AJR1999，172，2： | 1 |
| 3 | The role of the E-cadherin gene (CDHI) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice 显示文摘 | Graziano F Humar B Guilford P | 2003 | Ann Oncol2003，14，12： | 1 |
| 4 | The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice显示文摘 | GRAZIANO F HUMAR B GUILFORD P | 2003 | Ann One2003，14，： | 1 |
| 5 | ESD indirect coupling modeling显示文摘 | Graziano C Roberto D L Valter M P | 1996 | IEEE Trans on EMC1996，38，3： | 1 |
| 6 | Lineage specificity of the evolutionary dynamics of the mtDNA D-loop region in rodents 显示文摘 | Alessandra Larizza Graziano P esole Aurelio Reyes | 2002 | J Mol Evol2002，54，： | 1 |
| 7 | A rare case of primary pulmonary epithelioid angiosarcoma detected by ( 18)F-FDG PET/CT显示文摘 | Treglia G Cardillo G Graziano P | 2014 | Clin Nucl Med2014，39，5： | 1 |
| 8 | An algo- rithm for finding signals of unknown lengthinDNAse- quences 显示文摘 | GIULIO P GIANCARLO M GRAZIANO P | 2001 | Bioinformatics2001，4，3： | 1 |
| 9 | The role of the E-cadherin gene ( CDHI ) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice 显示文摘 | Graziano F Humar B Guilford P | 2003 | Ann Oneol2003，14，12： | 1 |
| 10 | Local invasion of gastric cancer:CT finding and pathologic correlation using 5 mm incremental scanning,hypotonia and water filling显示文摘 | Broglia L Graziano P | 1999 | AJR1999，，： | 1 |
| 11 | Local invasion of gastric cancer:CT findings and pathologic correlation using 5-mm incremental scanning, hypotonia, and water filling 显示文摘 | Rossi M Broglia L Graziano P | 1999 | AJR1999，172，2： | 1 |
| 12 | Location of ae sources in the rock foundation of the passante dam 显示文摘 | CARABELLI E FEDERICI P GRAZIANO F RONDENA E ZANINETTI A | 1990 | Engineering Fracture Mechanics1990，35，3： | 1 |
| 13 | Traumatic brain injury:oxida-tive stress and neuroprotection显示文摘 | Cornelius C Crupi R Calabrese V Graziano A Milone P Pennisi G Ra-dak Z Calabrese EJ Cuzzocrea S | | 0，，： | 1 |
| 14 | Improving of nitrogen efficiency by addition of ammonium thiosulfate in the liquid fertilization of maize 显示文摘 | GRAZIANO P L | 1990 | Fertilizer Research1990，24，2： | 1 |
| 15 | Intraperitoneal paclitaxel as consolidation treatment in ovarian cancer patients: a case control study显示文摘 | Benedetti Panici P Palaia I Graziano M | 2010 | Oncology2010，78，1： | 1 |
| 16 | Local invasion of gastric cancer:CT findings and pathologic correlation using 5mm incremental scanning,hypotonia,and water filling显示文摘 | Rossi M Broglia L Graziano P | 1999 | AJR1999，172，2： | 1 |
| 17 | Substance P innervation of lumbar spine facet joints显示文摘 | Beaman D N Graziano G P Glover R A | 1993 | Spine1993，18，8： | 1 |
| 18 | Dose-related impact of alcohol consumption on cognitive function in advanced age:results of a multicenter survey显示文摘 | Giuseppe Z Graziano O Claudio P | 2001 | Alcohol Clin Exp Res2001，25，12： | 1 |
| 19 | Diferent does of pamidronate in patients with painfull osteolytic bone metastasesrltaly 显示文摘 | Cascinu S Graziano F Alessandroni P | 1998 | Support Care Cancer1998，6，2： | 1 |
| 20 | Classification of human er- rors in grounding and collision accidents using the TRACEr taxono- my显示文摘 | Graziano A Teixeira A P Soares G C | 2016 | Safety Science2016，86，： | 1 |
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