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| 1 | Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data显示文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. | Manish Chand Deborah S Keller Reza Mirnezami Marc Bullock Aneel Bhangu Brendan Moran Paris P Tekkis Gina Brown Alex Mirnezami Mariana Berho | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 2 |
| 2 | Are HLA class II and immunoglobulin constant region genes involved in the pathogenesis of mixed cryoglobulinemia type II after hepatitis C virus infection?显示文摘 | Antonio Amoroso Monica Berrino Lorena Canale Maura Cornaglia Simonetta Guarrera Gina Mazzola Silvana Savoldi Francesco Scolari Matti S?llberg Massimo Clementi Armando Gabrielli | 1998 | Journal of Hepatology1998，，1： | 1 |
| 3 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 4 | Nitrogen con- tent of soils of the southern coast of Crimea (Russian) 显示文摘 | Kostychev S Sheloumova A Shul' gina O | 1926 | Sovetskii Agronomy1926，1，： | 1 |
| 5 | Formaldehyde-induced gene expression in F344 rat nasal respiratory epithelium显示文摘 | Hester S D Gina B B Lawrence Y | 2003 | Toxicology2003，187，： | 1 |
| 6 | Comparison of Erythrocyte Fatty Acid Composition of Lacto - ovo Vegetarians and Non -Vegetarians显示文摘 | BONNY B W GINA S S SUJATHAU R | 2006 | FASEB J2006，3，20： | 1 |
| 7 | Benefits of working as a certified peer specialist : Results from a statewide survey 显示文摘 | MARK S NICOLE D GINA C | 2013 | Am Psychol As- soc2013，36，3： | 1 |
| 8 | Hypothyroidism显示文摘 | Gina M David J A Jerrold P S | 2001 | Cancer2001，92，11： | 1 |
| 9 | A randomized controlled trial of Human Papillomavirus (HPV) testing for cervical cancer screening:trial design and preliminary results显示文摘 | Gina S Ogilvie Dirk J van Niekerk Mel krajden | | 0，，02： | 1 |
| 10 | Involvement of follicular stem cells in forming not only the follicle but also the epidermis显示文摘 | Taylor Gina Michael S Lehrer | 2000 | Cell2000，102，： | 1 |
| 11 | Alliance Portfolio Resource Diversity and Finn Innovation显示文摘 | Cui Anna S OConnor Gina | 2012 | Journal of Marketing2012，76，4： | 1 |
| 12 | Wisdom from the drought: Recommendations from a consuhative conference 显示文摘 | GINA S BRYAN H ANNE T | 2005 | Aust J Rural Health2005，13，： | 1 |
| 13 | Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer显示文摘 | Rollin J Régina S Vourc'h P | 2007 | Lung Cancer2007，56，2： | 1 |
| 14 | Wisdom from the drought: Recommendations from a consultative conference 显示文摘 | Gina S Bryan H Anne T | 2005 | Aust J Rural Health2005，13，： | 1 |
| 15 | Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion显示文摘 | Zully Pedrozo Gina Sánchez Natalia Torrealba Rodrigo Valenzuela Carolina Fernández Cecilia Hidalgo Sergio Lavandero Paulina Donoso | 2009 | BBA - Molecular Basis of Disease2009，，3： | 1 |
| 16 | Sexually transmitted infection control with sex workers: regular screening and presumptive treatment augment efforts to reduce risk and vulnerability 显示文摘 | RICHARD S GINA D | 2003 | Reproductive Health Matters2003，11，22： | 1 |
| 17 | Organisational approaches to building a radical innovation dynamic capability显示文摘 | OCONNOR GINA COLARELLI PAULSON ALBERT S DEMARTINO RICHARD | 2008 | International Journal of Technology Management2008，44，12： | 1 |
| 18 | Children living in areas with more street trees have lower asthma prevalence 显示文摘 | GINA S L JAMES W Q KATHRYN M N | 2008 | J Epidemiol Communi- ty Health2008，62，： | 1 |
| 19 | Influence of MMP-2and MMP-9 promoter polymorphisms on gene expression and clini-cal outcome of non-small cell lung cancer显示文摘 | J ROLLIN S RGINA P VOURC'H | 2007 | Lung Cancer(Am-sterdam Netherlands)2007，56，2： | 1 |
| 20 | The Effect of Organic Carbon on The Sequential Reductive Dehalogenation of Tetrachloroethylene in Landfill Leachates 显示文摘 | Joseph G Leahy Gina S Shreve | 2000 | War Res2000，34，8： | 1 |
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