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| 1 | Using the polymerase chain reaction coupled with denaturing gradient gel electrophoresis to investigate the association between bacterial translocation and systemic inflammatory response syndrome in predicted acute severe pancreatitis显示文摘AIM: To investigate the use of PCR and DGGE to investigate the association between bacterial translocation and systemic inflammatory response syndrome in predicted severe AP.METHODS: Patients with biochemical and clinical evidence of acute pancreatitis and an APACHE Ⅱ score ≥8 were enrolled. PCR and DGGE were employed to detect bacterial translocation in blood samples collected on d1,3, and 8 after the admission. Standard microbial blood cultures were taken when there was clinical evidence of sepsis or when felt to be clinically indicated by the supervising team.RESULTS: Six patients were included. Of all the patients investigated, only one developed septic complications;the others had uneventful illness. Bacteria were detected using PCR in 4 of the 17 collected blood samples. The patient with sepsis was PCR-positive in two samples (taken on d 1 and 3), despite three negative blood cultures. Using DGGE and specific primers, the bacteria in all blood specimens which tested positive for the presence of bacterial DNA were identified as E coli.CONCLUSION: Our study confirmed thatunlike traditional microbiological techniques, PCR can detect the presence of bacteria in the blood of patients with severe AP. Therefore, this latter method in conjunction with DGGE is potentially an extremely useful tool in predicting septic morbidity and evaluating patients with the disease. Further research using increased numbers of patients, in particular those patients with necrosis and sepsis, is required to assess the reliability of PCR and DGGE in the rapid diagnosis of infection in AP. | Callum B Pearce Vitaly Zinkevich Iwona Beech Viera Funjika Ana Garcia Ruiz Afraa Aladawi Hamish D Duncan | 2005 | World Journal of Gastroenterology2005，11，45： | 11 |
| 2 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 3 | The Virtual Geoscience Workbench, VGW: Open Source tools for discontinuous systems显示文摘In 1989 work began on merging finite and discrete elements. During 1990 algorithmic solutions for the new combined method were developed, together with a C-based implementation known as the Y code. In 2004 these developments and implementations were published as a textbook. Queen Mary University of London (QMUL) and Imperial College are currently engaged in a research project to make Y codes in both 2D and 3D available in Open Source format and with mainly geoscience problems in mind. The result is a set of Open Source tools for Geoscience (VGW), key components of which are summarised in this paper, together with illustrative range of simulation results. | A. Munjiza J. Xiang X. Garcia J.P. Latham G.G. Schiava D'Albano N.W.M. John | 2010 | Particuology2010，8，2： | 4 |
| 4 | 非运动症状负担、情绪和步态障碍是导致帕金森病非痴呆患者生活质量下降的最重要因素显示文摘帕金森病存在多种运动和非运动症状表现,其中非运动症状对于帕金森病患者生活质量的影响更为严重。改善帕金森病非运动症状,有助于提高患者的生活质量。既往帕金森病非运动症状研究多为单中心小样本研究,所涉及的非运动症状类型较为局限,无法全面反映非运动症状对帕金森病患者生活质量的影响。为此,该研究通过分析COPPADIS-2015研究队列来关注帕金森病患者非运动症状对其生活质量的影响。该队列是西班牙全国范围内为期5年的多中心综合观察性随访队列研究。 | 张煜(编译) Santos Garcia D de Deus Fonticoba T Suarez Castro E | 2020 | 中华医学杂志2020，100，27： | 3 |
| 5 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 6 | Nd3+ ion based self frequency doubling solid state lasers显示文摘 | JAQUE D CAPMANY J GARCIA J | 1999 | Optical Materials1999，13，2： | 2 |
| 7 | 知证卫生决策工具之十一--查找和使用当地证据显示文摘当地证据是指来源于卫生政策或卫生项目所涉及的特定环境的证据。需要这类证据与其它形式的证据共同支持方案决择。全球证据是判断政策效果及其影响因素和深入了解问题解决办法的最佳出发点。而当地证据大多数是在判断应采纳哪些决定及采取哪些措施时使用。本文提出以下5个问题供政策制定者在识别和评价当地证据进行知证决策时参考:①知证决策需要什么样的当地证据?②如何获得必需的当地证据?③如何评价现有当地证据的质量?④当地证据的可获得性、质量或结果是否有重要变化?⑤如何整合当地证据与其他信息? | Simon Lewin Andrew D Oxman John N Lavis Atle Fretheim Sebastian Garcia Marti Susan Munabi-Babigumira 李幼平 王莉 成岚 蒋兰慧 蔡羽嘉 | 2010 | 中国循证医学杂志2010，10，4： | 2 |
| 8 | Depression and psychiatric disease associated with outcomes after anterior cruciate ligament reconstruction显示文摘While most patients with an anterior cruciate ligament(ACL) injury indicate satisfaction with surgical intervention, a significant proportion still do not return to pre-injury level of function or sport. Psychiatric comorbidities, such as depression, have recently been associated with poor clinical outcomes after ACL reconstruction(ACLR). To date, no article has yet examined how depression affects ACLR outcomes and how potential screening and intervention for psychological distress may affect postoperative activity level. The purpose of this review is to delineate potential relationships between depression and ACLR outcome, discuss clinical implications and identify future directions for research. | Hao-Hua Wu Max Liu Joshua S Dines John D Kelly Grant H Garcia | 2016 | World Journal of Orthopedics2016，7，11： | 2 |
| 9 | Assessment of metal contamination in donana national park (spain) using crayfish (proeamburus elarkia) 显示文摘 | Sanchez Lopez F J Gil Garcia M D Martinez Vidal J | 2004 | Environmental Monitoring and Assessment2004，，93： | 1 |
| 10 | Routing mechanisms for mobile ad hoe networks based on the energy drain rate显示文摘 | Kim D Garcia - Luna - Aceves J Obraezka K | 2003 | IEEE Transactions on Mobile Computing2003，2，2： | 1 |
| 11 | Antimicrobial activity and phytochemical studies of some lichens from south of Spain显示文摘 | SAENZ M T GARCIA M D ROWE J G | 2006 | Fitoterapia2006，77，： | 1 |
| 12 | Reaction synthesized Al2O3-based intermetalic composites显示文摘 | GARCIA D E BRUHN J | 1998 | Acta Mater1998，46，7： | 1 |
| 13 | Reliability and predictive validity of the Motivated Strategies for Learning Questionnaire (Mslq)显示文摘 | Pintrich P R Smith D A F Garcia T | 1993 | Educational and Psychological Measurement1993，53，3： | 1 |
| 14 | Incidence and Mortality of Generalized Convulsive Status Epilepticus in California显示文摘 | Wu Y W Shek D W Garcia P A | 2002 | Neurology2002，58，7： | 1 |
| 15 | Antibiotic bisanthraquinones produced by a Slxeptomycete isolated from a cyanobacterium associated with Ecteinascidia turbinate 显示文摘 | SOCHA A M GARCIA D SHEFFER R | 2006 | J Nat Prod2006，69，7： | 1 |
| 16 | The Demise of the High Fru- ctose Corn Syrup Futures Contract :A Case Study显示文摘 | THOMPSON S GARCIA P WILDMAN L D | 1996 | Futures Markets1996，16，6： | 1 |
| 17 | Watershed infarcts in transient ischemic attack/minor stroke with > or 50o/00 carotid stenosis: hemodynamic or embolie? 显示文摘 | Moustafa RR Izquierdo Garcia D Jones PS | 2010 | Stroke2010，41，7： | 1 |
| 18 | Array comparative genomic hybridization identifies genetic regions associated with outcome in aggressive dif- fuse large B-cell lymphomas显示文摘 | Robledo C Garcia JL Caballero D | 2009 | Cancer2009，115，16： | 1 |
| 19 | Spin reorientation transitions in ReF14 BHx compounds 显示文摘 | Kuzmin M D Garcia L M Haza I | 1995 | Journal of Magnetism and Magnetic Materials1995，146，3： | 1 |
| 20 | Glomeruli and Blood Pressure:Less of One,More of the Other显示文摘 | Brenner B M Garcia D L Anderson S | 1988 | Hypertens1988，1，： | 1 |
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