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| 1 | 泻阴补阳合巨刺针刺法治疗脑卒中后肌张力障碍Ashworth痉挛量表的临床疗效观察显示文摘目的:观察泻阴补阳合巨刺法治疗脑卒中后肌张力障碍Ashworth痉挛量表的临床疗效。方法:120例脑卒中后肌张力障碍患者采用随机分组法分为治疗组A组和对照组B、C、D组,治疗组采用泻阴补阳合巨刺针刺法,对照组B组采用传统针刺法合巨刺法,C组采用泻阴补阳针刺法,D组采用传统针刺法,每组各30例患者,每位患者均在脑卒中的西医常规治疗方法的基础上进行治疗。治疗前后采用Ashworth痉挛量表进行评定。结果:泻阴补阳合巨刺法对脑卒中后肌张力障碍的治疗效果明显优于对照组。结论:泻阴补阳合巨刺法对脑卒中后肌张力障碍的疗效显著,能有效改善患者的运动功能和生活能力。 | 李作伟 李平 Eudes Saturnin Régis ITOUA Franoise NDINGAANDELY Donatien MOUKASSA | 2016 | 世界中医药2016，11，2： | 11 |
| 2 | 泻阴补阳合巨刺针刺法治疗脑卒中后肌张力障碍运动功能评级Brunnstrom的疗效观察显示文摘目的:观察泻阴补阳合巨刺法治疗脑卒中后肌张力障碍运动功能评级Brunnstrom的临床疗效。方法:120例脑卒中后肌张力障碍患者采用随机分组的方法分为泻阴补阳合巨刺法针刺组A组、传统针刺合巨刺法针刺B组、泻阴补阳针刺法组C组、传统针刺组D组,每组各30例患者,每位患者均在脑卒中的西医常规治疗方法的基础上进行治疗。治疗前后采用运动功能评级Brunnstrom评分量表的方法。结果:泻阴补阳合巨刺法对脑卒中后肌张力障碍的改善优于其他3组对照组。结论:泻阴补阳合巨刺法对治疗脑卒中后肌张力障碍有很好的临床疗效,优于传统针刺疗法,能达到有效的改善患者的肢体运动功能的目的,并提高患者的生活能力。 | 李作伟 Donatien MOUKASSA Eudes Saturnin Régis ITOUA Franoise NDINGA ANDELY 李平 李艳冉 | 2015 | 中华中医药学刊2015，33，10： | 4 |
| 3 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 4 | Outcomes of curative esophageal cancer surgery in elderly:A metaanalysis显示文摘BACKGROUND An increasing number of older patients is undergoing curative,surgical treatment of esophageal cancer.Previous meta-analyses have shown that older patients suffered from more postoperative morbidity and mortality compared to younger patients,which may lead to patient selection based on age.However,only studies including patients that underwent open esophagectomy were included.Therefore,it remains unknown whether there is an association between age and outcome in patients undergoing minimally invasive esophagectomy.AIM To perform a systematic review on age and postoperative outcome in esophageal cancer patients undergoing esophagectomy.METHODS Studies comparing older with younger patients with primary esophageal cancer undergoing curative esophagectomy were included.Meta-analysis of studies using a 75-year age threshold are presented in the manuscript,studies using other age thresholds in the Supplementary material.MEDLINE,Embase and the Cochrane Library were searched for articles published between 1995 and 2020.Risk of bias was assessed with the Newcastle-Ottawa Scale.Primary outcomes were anastomotic leak,pulmonary and cardiac complications,delirium,30-and 90-d,and in-hospital mortality.Secondary outcomes included pneumonia and 5-year overall survival.RESULTS Seven studies(4847 patients)using an age threshold of 75 years were included for meta-analysis with 755 older and 4092 younger patients.Older patients(9.05%)had higher rates of 90-d mortality compared with younger patients(3.92%),(confidence interval=1.10-5.56).In addition,older patients(9.45%)had higher rates of in-hospital mortality compared with younger patients(3.68%),(confidence interval=1.01-5.91).In the subgroup of 2 studies with minimally invasive esophagectomy,older and younger patients had comparable 30-d,90-d and in-hospital mortality rates.CONCLUSION Older patients undergoing curative esophagectomy for esophageal cancer have a higher postoperative mortality risk.Minimally invasive esophagectomy may be important for minimizing mortality in older patients. | Nikolaj S Baranov Cettela Slootmans Frans van Workum Bastiaan R Klarenbeek Yvonne Schoon Camiel Rosman | 2021 | World Journal of Gastrointestinal Oncology2021，13，2： | 3 |
| 5 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 6 | Current advances in abscisic acid action and signalling显示文摘 | Jér?me Giraudat Fran?ois Parcy Nathalie Bertauche Fran?oise Gosti Jeffrey Leung Peter-Christian Morris Michelle Bouvier-Durand Nicole Vartanian | 1994 | Plant Molecular Biology1994，，5： | 1 |
| 7 | Corrosion of the reinforcement and its influence on the residual structural performance of a 26-year-old corroded RC beam 显示文摘 | Zhu W Fran?ois R | 2014 | Construction and Building Materials2014，51，： | 1 |
| 8 | Transplantation of cultured explants of human endometrium into nude mice显示文摘 | Michelle N Franoise R Etienne M | 2000 | Hum Repod2000，15，3： | 1 |
| 9 | Microbio- logical safety and quality of commercial sufu and Chinese fermented soybean food 显示文摘 | Han Bei zhong Rijkelt R Rombouts Frans M | 2001 | Food Control2001，，12： | 1 |
| 10 | Effect of stress corrosion cracking on stress strain response of steel wires used in prestressed concrete beams显示文摘 | VU N A CASTEL A FRAN OIS R | 2009 | Corrosion Science2009，51，6： | 1 |
| 11 | Reproducibility of blood tests of liver fibrosis in clinical practice显示文摘 | Paul Calès Pascal Veillon Anselme Konaté Elisabeth Mathieu Catherine Ternisien Alain Chevailler Alban Godon Yves Gallois Fran?oise Joubaud Isabelle Hubert-Fouchard Frédéric Oberti Stéphane Réaud Gilles Hunault Fran?oise Mauriat Fran?oise Lunel-Fabiani | 2007 | Clinical Biochemistry2007，，1： | 1 |
| 12 | Energy analysis of advanced collective farms in North China显示文摘 | HAN C R FRAN G ZHENG G M | 1985 | Agrculture Ecosystems and Environment1985，13，： | 1 |
| 13 | Regional kendall test for trend显示文摘 | Helsel D R Frans L M | 2006 | Environmental Science and Technology2006，40，13： | 1 |
| 14 | Regional Kendall test for trend显示文摘 | Helsel D R Frans L M | | 0，，： | 1 |
| 15 | The influence of dynamic soil-structure interaction on traffic induced vibrations in buildings 显示文摘 | Fran ois S Pyl L Masoumi H R Degrande G | 2007 | Soil Dynamics and Earthquake Engineering2007，27，7： | 1 |
| 16 | Different approaches to assessment of design and management of sustainable urban water systems显示文摘 | Michiel A R Frans H M van de Ven | 2000 | Environment Impact Assessment Review2000，129，3： | 1 |
| 17 | Effect of exogenous creatine supplemention on muscle PCr metabolism 显示文摘 | Fran Caux M Demeure R Goudemant JF | 2000 | Int J Sport Med2000，21，： | 1 |
| 18 | Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia显示文摘 | Catherine M. Pastor Jér?me Pugin Brenda Kwak Marc Chanson Fran?ois Mach Antoine Hadengue Jean Louis Frossard | 2004 | Critical Care Medicine2004，，8： | 1 |
| 19 | Aortic Wrapping for Stanford Type A Acute Aortic Dissection: Short and Midterm Outcome显示文摘 | Pierre Demondion Ramzi Ramadan Alexandre Azmoun Fran?ois Raoux Claude Angel Rémi Nottin Philippe Deleuze | 2013 | The Annals of Thoracic Surgery2013，，： | 1 |
| 20 | Evaluation of the ulnopalmar arterial arches with pulse oximetry and plethysmography: Comparison with the Allen’s test in 1010 patients显示文摘 | Gérald R Barbeau Fran?ois Arsenault Louise Dugas Serge Simard Marie Mai Larivière | 2004 | American Heart Journal2004，，3： | 1 |
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