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| 1 | Lactobacilli,bifi dobacteria and E.coli nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells显示文摘AIM: To investigate whether the stimulation of peripher- al blood mononuclear cells (PBMNC) with the cell debris and cell extraction of different probiotic strains is similar or species specifi c. METHODS: Three strains of bifi dobacteria, 4 strains of lactobacilli, and E. coli nissle were sonicated and centri- fuged in order to divide them into cell extract and cell debris. PBMNC were separated by density gradient and incubated for 36 h with either the cell debris or the cell extract of single strains of probiotic bacteria in doses from 102 to 108 CFU/mL. Cell supernatants were taken and interleukin (IL)-10, IL-1β, and tumor necosis factor (TNF)-α were determined by ELISA. RESULTS: Depending on the species super-family, the strains had different stimulation patterns. Except for both L. casei strains, the cell extract of bifidobacteriaand lactobacilli had less stimulating capacity than cell debris, whereas the cell extract of E. coli nissle had simi- lar stimulating properties to that of the cell debris of the strain and significantly more stimulating capacity than that of bifi dobacteria and lactobacilli. The cell debris of bifi dobacteria stimulated more cytokine release than the cell debris of lactobacilli. The cell debris of lactobacilli did not have a stimulating capacity when lower concentra- tions were used. Neither cell extraction nor cell debris had an inhibitory effect on the production of the tested cytokines by stimulated PBMNC. CONCLUSION: The incubation of probiotic strains, which have been used in clinical trials for inflammatory diseases, with immunocompetent cells leads to different species specifi c reactions. High IL-10 response to cell de- bris of bifi dobacteria and E. coli nissle can be found. This corresponds to positive effects of bifi dobacteria and E. coli nissle in clinical trials for inflammatory bowel disease compared to negative outcomes obtained with lactoba- cilli. | Ulf Helwig Karen M Lammers Fernando Rizzello Patricia Brigidi Verena Rohleder Elisabetta Caramelli Paolo Giochetti Juergen Schrezenmeir Ulrich R Foelsch Stefan Schreiber Massimo Campieri | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 2 | Boron particle ignition and combustion at 30-150 atm显示文摘 | Robert O Foelsche Rodney L Burton | 1999 | Combustion and Flame1999，117，： | 1 |
| 3 | Lioase-catalyzed resolution of acyclic amino alcohol precursors显示文摘 | Foelsche E Hickel A Honig H | 1990 | J Org Chem1990，55，6： | 1 |
| 4 | Magnetfeld und induktivitit einer zylindrischen spule显示文摘 | Foelsch K | 1935 | Archiv Fur Elektrotechnik1935，30，3： | 1 |
| 5 | Recent developments in amorphous silicon-based solar cells 显示文摘 | Beneking C Rech B Foelsch J | 1996 | Phys Stat Sol B1996，194，1： | 1 |
| 6 | Recent developments in amorphous silicon-based solar cells 显示文摘 | Beneking C Rech B Foelsch J | 1996 | Physica Status Solidi(B)1996，194，1： | 1 |
| 7 | High pressure ignition of boron in reduced oxygen atmospheres显示文摘 | Foelsche R O Spalding M J Burton R L | 1996 | Decompo- sition Combustion and Detonation Chemistry of Energetic Materials1996，418，： | 1 |
| 8 | Boron particle ignition and combustion at 30-150 ATM 显示文摘 | Foelsche R O R L Burton H Krier | 1999 | Combustion and Flame1999，117，12： | 1 |
| 9 | Refractivity and temperature climate records from multiple radio occultation satellites consistent within 0.05%显示文摘 | Foelsche U. Scherllin-Pirscher B. Ladst?dter F. Steiner A. K. Kirchengast G | 2011 | Atmospheric Measurement Techniques2011，，23： | 1 |
| 10 | Lack of association between the C3435T MDR1 gene polymorphism and inflammatory bowel disease in two independent Northern European populations显示文摘 | Croucher PJ Mascheretti S Foelsch UR | 2003 | Gastroenterology2003，125，6： | 1 |
| 11 | Boron particle ignition and combustion at 30-150 ATM显示文摘 | Foelsche R O Burton R L Krier H | 1999 | Combustion and Flame1999，117，12： | 1 |
| 12 | Boron particle ignition and combustion at 30–150 atm显示文摘 | Robert O. Foelsche Rodney L. Burton Herman Krier | 1999 | Combustion and Flame1999，，1： | 1 |
| 13 | A new ' geometric ' mapping function for the hydrostatic delay at GPS frequencies 显示文摘 | Foelsche U Kirchengast G | 2001 | Physics and Chemistry of the Earth Part A : Solid Earth and Geodesy2001，26，3： | 1 |
| 14 | Assessing the cli- mate monitoring utility of radio occultation data: From CHAMP to FORMOSAT-3/COSMIC显示文摘 | Foelsche U Pirscher B Borsche M | 2009 | Terrestrial Atmos- pheric and Oceanic Sciences2009，20，1： | 1 |
| 15 | Boron particle ignition and combus- tion at 30-150atm显示文摘 | Foelsche R Burton R Herman K | 1999 | Combustion and Flame1999，117，1： | 1 |
| 16 | Tropospheric water vapor imaging by combination of ground-based and spaceborne GNSS sounding data显示文摘 | Ulrich Foelsche | 2001 | J Geophy Res2001，106，27： | 1 |
| 17 | Attachment style,history,and behavioral contrasts for a borderline and normal sample显示文摘 | Sack A Sperling MB Fagen G Foelsch P | 1996 | J Personal Disord1996，10，： | 1 |
| 18 | A Comparison of Intraarticular Lumbar Facet Joint Steroid Injections and Lumbar Facet Joint Radiofrequency Denervation in the Treatment of Low Back Pain: A Randomized, Controlled, Double-Blind Trial显示文摘 | Stefan Lakemeier Marcel Lind Wolfgang Schultz Susanne Fuchs-Winkelmann Nina Timmesfeld Christian Foelsch Christian D. Peterlein | 2013 | Anesthesia & Analgesia2013，，： | 1 |
| 19 | The development of a psychodynamic treatment for patients with borderline personality disorder:a preliminary study of behavioral change显示文摘 | Clarkin JF Foelsch PA Levy KN | 2001 | J Pers Disord2001，15，： | 1 |
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