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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Catalytic reduction of nitrate and nitrite on Pt- Cu/Al2O3 catalysts in aqueous solution:role of the interaction between copper and platinum in the reaction显示文摘 | Florence E Florence G Carole P | 2001 | Journal of Catalysis2001，198，： | 3 |
| 3 | A statistical contribution to the theory of women's wages 显示文摘 | Florence P S | 1931 | The Economic Journal1931，41，161： | 1 |
| 4 | Nanospheres and microsphere uptake via Peyer's patches:observation of the rate of uptake in the rat after a single oral dose显示文摘 | Jani P Florence A T | 1992 | Int J Pharm1992，86，： | 1 |
| 5 | Live attenuated Salmonella:Aparadigm of mucosal vaccines显示文摘 | Jean C S Florence N Jean P K | 1999 | Immunol Rev1999，171，： | 1 |
| 6 | Sequential events in thymocyte differentiation and thymus regeneration revealed by a combination of bromedeoxyuridine DNA labeling and antimitic drug treatment显示文摘 | Claude P Florence V | 1998 | J Immunol1998，15，： | 1 |
| 7 | Comparative, quantitative study of lymphoid and non-lymphoid Uptake of 60 nm polystyrene particles显示文摘 | Hillery AM Jani P Florence AT | 1994 | J Drug Target1994，2，2： | 1 |
| 8 | Spend residue from cumin-A potential source of dietary fiber显示文摘 | SOWBHAGYA H B FLORENCE P S | 2007 | Food Chemistry2007，104，： | 1 |
| 9 | Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency 显示文摘 | Jani P Halbert G W Langridge J Florence A T | 1990 | J Pharm Pharmacol1990，42，12： | 1 |
| 10 | Studies on electrodeposition of copper from methanesulphonic acid bath 显示文摘 | FLORENCE F J NISHA P RAJENDRAN S | 2010 | International Journal of ChemTech Research2010，3，3： | 1 |
| 11 | The uptake and translocation of latex nanospheres and mierospheres after oral administration to rats显示文摘 | Jani P Halbert G W Langridge J Florence A T | 1989 | J Pharm Pharmacol1989，41，12： | 1 |
| 12 | A new polymorphism in the ApoE promoter associ-ated with risk of developing Alzheimer′s Disease显示文摘 | Jean-chaarles L Florence P Dominique C | 1998 | Human Molecular Genetics1998，7，3： | 1 |
| 13 | Inflammatory cytokines C reative protein and procalcitonin as early predictors of necrosis in- fection in acute necrotizing pancreatitis 显示文摘 | Florence C Riche MD Bernard P | 2003 | Surgery2003，133，3： | 1 |
| 14 | Denoising NMR time-domain sig- nal by singular-value decomposition accelerated by graphics processing unites显示文摘 | Pascal P M Christian B Florence B | 2014 | Solid State Nuclear Magnetic Resonance2014，61，5： | 1 |
| 15 | A statistical contribution to the theory of women's wages显示文摘 | Florence P S | 1931 | Economic Journal1931，，41： | 1 |
| 16 | Spent residace from cumin--a potential source of dietary fiber显示文摘 | SOWBHAGYA H B FLORENCE S P MAHADEVAMMA S | 2007 | Food Chemistry2007，，4： | 1 |
| 17 | Recent advances inquantitative PCR(qPCR) applications in food microbiology 显示文摘 | Florence P Helene F Sona P | 2011 | Food Microbiology2011，28，5： | 1 |
| 18 | Coneeptual and operational aspects of brand loyalty显示文摘 | Odin Y Odin N Valette- Florence P | 2001 | Journal of business research2001，53，8： | 1 |
| 19 | Wood durability of home - garden teak against brown - rot and white - rot fungi显示文摘 | Bhat K M Thulasidas P K Maria Florence E J | 2005 | Trees2005，19，： | 1 |
| 20 | Effect of copper on growth in cucumber plants (Cucumis sativus) and its relationships with carbohydrate accumulation and change in ion contents 显示文摘 | BADR A S GENET P FLORENCE V D | 2004 | Plant Science2004，166，5： | 1 |
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