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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 3 | Ozonation of a landfill leachate: evaluation of toxicity removal and biode gradability improvement显示文摘 | BILA D M FILIPE M A SILVA A C | 2005 | Journal of Hazardous Materi als2005，117，2： | 1 |
| 4 | Carbon nanotube field-effect transistor detector associated to gas chromatography for speciation of benzene, toluene, ethylbenzene, ( o-, m- and p-) xylene 显示文摘 | LURDES I B S FILIPE D P F TERESA A P R S | 2009 | Journal of Chromatography A2009，1216，37： | 1 |
| 5 | The hyperlipidemic hamster as model of experimental atheroscelerosis显示文摘 | Nistor A Bulla A Filip D A &Radu A | 1987 | Atherosclerosis1987，68，： | 1 |
| 6 | Long-termDurability of Reinforced and Prestressed Elements inAggressive Environments显示文摘 | MIRCEA D IOANI A FILIP M | 1994 | ACI Materials Journal1994，91，2： | 1 |
| 7 | The effects of grape seeds polyphenols on SKH - 1 mice skin irradiated with multiple doses of UV -B 显示文摘 | Filip A Daicoviciu D Clichici S | 2011 | Journal of Photochemistry and Photobiology B : Biology2011，105，： | 1 |
| 8 | A thermodynamic analy- sis of hydrogen production by steam reforming of glycerol 显示文摘 | Adhikaria S Femandoa S Gwaltney S R Filip S D Bfic- ka R M Steele P H Haryanto A | 2007 | International Journal of Hydrogen Energy2007，32，： | 1 |
| 9 | Decision Support for Blend Monitoring in Proce Induries显示文摘 | Filip F G Donciulescu A D Neagu G | 1998 | Computers in Indury1998，36，12： | 1 |
| 10 | Modeling of cyclic shear behavior in rc members 显示文摘 | Angelo D A Filip C F | 1999 | Journal of Structural Engineering ASCE1999，125，10： | 1 |
| 11 | Synthesis and characterization of polymer/clay nanocomposites by interca- lated chain transfer agent显示文摘 | Hakan A Mehmet A T Filip D P | 2008 | Eur Potym J2008，，44： | 1 |
| 12 | The Role of Past Performance in Export ventures:A Short -term Reactive Ap- proach显示文摘 | Luis Filipe Lages Sandy D Jap David A Griffith | 2008 | Journal of International Business Studies2008，39，： | 1 |
| 13 | Early combined immunosuppression or conventionalmanagement in patients with newly diagnosed Crohn' s disease:an open randomised trial 显示文摘 | Geert D Filip B Gert V A | 2008 | Lancet2008，371，9613： | 1 |
| 14 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 1 |
| 15 | Aromatic polysulfones for flame retardancy显示文摘 | MACOCINSCHI D GRIGORIU A FILIP D | 2002 | European Polymer Journal2002，38，： | 1 |
| 16 | Mixed radiation-convection boundarylayer flow of an optically dense fluid along a vertical flat plate in a non-Darcy porous medium显示文摘 | Takhar H S Beg O A Chamkha A J Filip D Pop I | 2003 | Int J Applied Mechanics and Engineering2003，8，3： | 1 |
| 17 | Increased expresston of matrix metaUoprotetna ses In VLVO in sclerttts tisue and In vitroin cul-turcd human scleral fibroblasts显示文摘 | Lloyd A Filipic M Wake--field D | 1997 | Am J Pathoi1997，150，2： | 1 |
| 18 | Increased expression of matrix metalloproteinases in vivo in scleritis tissue and in vitro in cultured human scleral fibroblasts显示文摘 | Di Girolamo N Lloyd A McCluskey P Filipic M Wakefield D | 1997 | Am J Pathol1997，150，2： | 1 |
| 19 | Modeling of cyclic shear behavior on remembers 显示文摘 | Angelo D A Filip C F | 1999 | Journal of Structural Engineering ASCE1999，125，10： | 1 |
| 20 | Mierosatellites and their ge- nomic distribution, evolution, function and applications: A lwiew with special reference to fish genetics显示文摘 | Chistiakov D A Hellemans B Filip A M | 2006 | Aquaculture2006，255，： | 1 |
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