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| 1 | Outcome of patients with acute, necrotizing pancreatitis requiring drainage-does drainage size matter?显示文摘AIM:To assess the outcome of patients with acute necrotizing pancreatitis treated by percutaneous drainage with special focus on the influence of drainage size and number. METHODS:We performed a retrospective analysis of 80 patients with acute pancreatitis requiring percutaneous drainage therapy for infected necroses. Endpoints were mortality and length of hospital stay. The influence of drainage characteristics such as the median drainage size, the largest drainage size per patient and the total drainage plane per patient on patient outcome was evaluated. RESULTS:Total hospital survival was 66%. Thirty-four patients out of all 80 patients (43%) survived acute necrotizing pancreatitis with percutaneous drainage therapy only. Eighteen patients out of all 80 patients needed additional percutaneous necrosectomy (23%). Ten out of these patients required surgical necrosectomy in addition, 6 patients received open necrosectomy without prior percutaneous necrosectomy. Elective surgery was performed in 3 patients receiving cholecystectomy and one patient receiving resection of the parathyroid gland. The number of drainages ranged from one to fourteen per patient. The drainage diameter ranged from 8 French catheters to 24 French catheters. The median drainage size as well as the largest drainage size used per patient and the total drainage area used per patient did not show statistically significant influence on mortality. CONCLUSION:Percutaneous drainage therapy is an effective tool for treatment of necrotizing pancreatitis.Large bore drainages did not prove to be more effective in controlling the septic focus. | T Bruennler J Langgartner S Lang CE Wrede F Klebl S Zierhut S Siebig F Mandraka F Rockmann B Salzberger S Feuerbach J Schoelmerich OW Hamer | 2008 | World Journal of Gastroenterology2008，14，5： | 23 |
| 2 | Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study显示文摘AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the possibility of accurate prediction of malignancy of hepatic tumors with a positive prognostic value of 93.5% using advanced contrast-enhanced ultrasound. Contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics is a valuable tool to discriminate hepatic tumors. | EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung | 2007 | World Journal of Gastroenterology2007，13，47： | 15 |
| 3 | Evidence for a transition from to thermally controlled solidification in metallic alloys 显示文摘 | ECKLER K COCHRANE R F HERLACH D M FEUERBACHER B JURISCH M | 1992 | Physical Review B1992，45，： | 1 |
| 4 | The yeast RPL9B gene is regulated by modulation between two modes of transcription termination 显示文摘 | Gudipati R K Neil H Feuerbach F | 2012 | EM BO2012，31，10： | 1 |
| 5 | : Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance显示文摘 | Beclin C Elmayan T Feuerbach F Godon C Morel JB Jouette D Lacombe AM Nikic S Picault N | 2000 | Cell2000，101，： | 1 |
| 6 | Creation and annihilation of free volume during homogeneous flow of a metallic glass显示文摘 | Heggen M Spaepen F Feuerbacher M | 2005 | Journal of Applied Physics2005，97，3： | 1 |
| 7 | 查看详情显示文摘 | Heggen M Spaepen F Feuerbacher M | | 0，，： | 1 |
| 8 | Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance显示文摘 | Béclin C Elmayan T Feuerbach F Godon C Mortl J-B Jouette D Lacombe A-M Nikic S Picault N Rémoué K Sanial M Vo T-A Vaucheret H | 2000 | Cell2000，101，： | 1 |
| 9 | Evidence for a transition from diffusion-controlled to thraally controlled solidification in metallic alloys 显示文摘 | ECKLER K COCHRANE R F HERLACH D M FEUERBACHER B JURISCH M | 1992 | Physical Review B1992，45，： | 1 |
| 10 | RNA-mediated transposition of the tobacco retrotransposon Tnt1 in Arabidopsis thaliana显示文摘 | FEUERBACH F KUNERT K | 1995 | EMBO J1995，14，： | 1 |
| 11 | RNA mediated transposition of the tobacco retrotransposon Tntl in Arabidopsis thaliana显示文摘 | LUCAS H FEUERBACH F KUNERT K | 1995 | EMBO J1995，14，： | 1 |
| 12 | RNA-mediated transposition of the tobacco retrotransposon Tntl in Arabidopsis thaliana显示文摘 | Lucas H Feuerbach F Kunert K | 1995 | The EMBO Journal1995，14，： | 1 |
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