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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Henoch-Schonlein Purpura Nephritis显示文摘 | Fernando F C | 2003 | Int J Dermatol2003，42，3： | 1 |
| 3 | On the use of cyanine dyes as low-band gap materials in bulkhetero junction photovoltaic deVices 显示文摘 | FERNANDO A C ANTONIN F THOMAS G | 2006 | Synthetic Metals2006，156，1415： | 1 |
| 4 | Cuff-leak test for the diagnosis of upper airway obstruction in adults : a systematic review and meta-analysis 显示文摘 | Mafia E O Maria C M Fernando F V | 2009 | Intensive Care Med2009，35，7： | 1 |
| 5 | Stress-strain relationship in axial compression for concrete using recycledsaturated coarse aggregate显示文摘 | BELEN G F FERNANDO M A DIEGO C L | 2011 | Construction and Building materials2011，25，5： | 1 |
| 6 | Multi-UAV cooperative perception teehniques显示文摘 | Luis M Fernando C Joaquin F | 2007 | Springer Tracts in Advanced Robot- ics2007，37，1： | 1 |
| 7 | Henoch Schonein purpura nephri- tis 显示文摘 | Fernando C Fervenza F C | 2003 | Int J Dermato2003，42，3： | 1 |
| 8 | Effect of sorption kinetics on nickel toxicity in methanogenic granular sludge 显示文摘 | JAN B FERNANDO G F Alba B C | 2010 | Journal of Hazardous Materials2010，180，： | 1 |
| 9 | Reagentless biosensor for isocitrate using one step modified Pt-Ir microelectrode 显示文摘 | PEREIRA A C FERNANDO L F NETO GDE O | 2001 | Talanta2001，53，4： | 1 |
| 10 | Effect of high fiber products on blood lipids and lipoproteins in hamsters 显示文摘 | Hector E M F Yoon K C Fernando M B | 2004 | Nutrition Research2004，24，： | 1 |
| 11 | Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory en-sheathing glia 显示文摘 | RAMON-CUETO ISABEL C FERNANDO F | 2000 | Neuron2000，25，： | 1 |
| 12 | Evaluation of the efficacy of triple therapy regimen for Helicobacter pylori eradication in gastrectomized patients with gastric adenocarcinoma显示文摘 | Jose Luiz Bertoli Neto Laercio Gomes Louren?o Cícero Fernando Bertoli Fábio Samsonowski Ulbrich Antoninho Ricardo Sabbi Alexandre Galv?o Bueno | 2006 | Gastric Cancer2006，，4： | 1 |
| 13 | Physical activity and exercise recommendations for stroke survivors显示文摘 | Nell F Meg G Fernando C | 2004 | Stroke2004，35，5： | 1 |
| 14 | Biochemical, physiological and structural effects of excess copper in plants显示文摘 | Fernandos J C Henriques F S | 1991 | Bot Rev1991，57，3： | 1 |
| 15 | Effect of copper and zinc on the activated sludge bacteria growth kinetics显示文摘 | Alberto C Sara F Fernando M | 1998 | Wat Res1998，32，： | 1 |
| 16 | Effect of the application of silicon hydroxide on yield and quality of cher- ry tomato 显示文摘 | Fernando T S Antonio V G Francisco C F | 2012 | Journal of Plant Nutrition2012，35，4： | 1 |
| 17 | Reagentless biosensor for isocitrate using one step modified Pt - Ir microelectrode显示文摘 | PEREIRA A C FERNANDO L F NETO G DE O | 2001 | Talanta2001，53，： | 1 |
| 18 | Kinetic evaluation and modeling of lignin catalytic wet oxidation to selective production of aromatic aldehydes显示文摘 | Fernando G Laisse C A M Nelson M L F | 2006 | American Chemical Society2006，45，20： | 1 |
| 19 | Mapping the domain of troponin T responsible for the activation of actomyosin ATPase activity显示文摘 | Clóvis R N Aurea D S Chuck S F Fernando C R | | J Biol Chem0，275，27： | 1 |
| 20 | Henoch Schonein purpura nephritis显示文摘 | Fernando C Fervenza F C | 2003 | Int J Dermatol2003，42，： | 1 |
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