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| 1 | An air quality forecasting system in Beijing-Application to the study of dust storm events in China in May 2008显示文摘An air pollution forecast system,ARIA Regional,was implemented in 2007-2008 at the Beijing Municipality Environmental Monitoring Center,providing daily forecast of main pollutant concentrations.The chemistry-transport model CHIMERE was coupled with the dust emission model MB95 for restituting dust storm events in springtime so as to improve forecast results.Dust storm events were sporadic but could be extremely intense and then control air quality indexes close to the source areas but also far in the Beijing area.A dust episode having occurred at the end of May 2008 was analyzed in this article,and its impact of particulate matter on the Chinese air pollution index (API) was evaluated.Following our estimation,about 23 Tg of dust were emitted from source areas in Mongolia and in the Inner Mongolia of China,transporting towards southeast.This episode of dust storm influenced a large part of North China and East China,and also South Korea.The model result was then evaluated using satellite observations and in situ data.The simulated daily concentrations of total suspended particulate at 6:00 UTC had a similar spatial pattern with respect to OMI satellite aerosol index.Temporal evolution of dust plume was evaluated by comparing dust aerosol optical depth (AOD) calculated from the simulations with AOD derived from MODIS satellite products.Finally,the comparison of reported Chinese API in Beijing with API calculated from the simulation including dust emissions had showed the significant improvement of the model results taking into accountmineral dust correctly. | Benoit Laurent Fanny Velay-Lasry Richard Ngo Claude Derognat Batrice Marticorena Armand Albergel | 2012 | Journal of Environmental Sciences2012，24，1： | 9 |
| 2 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 3 | Biological therapy in inflammatory bowel diseases:Access in Central and Eastern Europe显示文摘Biological drugs opened up new horizons in the management of inflammatory bowel diseases(IBD).This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European(CEE)countries,namely Bulgaria,the Czech Republic,Estonia,Hungary,Latvia,Lithuania,Poland,Romania and Slovakia.Literature data on the epidemiology and disease burden of IBD in CEE countries was systematically reviewed.Moreover,we provide an estimation on prevalence of IBD as well as biological treatment rates.In all countries with the exception of Romania,lower biological treatment rates were observed in ulcerative colitis(UC)compared to Crohn’s disease despite the higher prevalence of UC.Great heterogeneity(up to 96-fold)was found in access to biologicals across the CEE countries.Poland,Bulgaria,Romania and the Baltic States are lagging behind Hungary,Slovakia and the Czech Republic in their access to biologicals.Variations of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria,Latvia,Lithuania,and Poland,but association with other possible determinants(differences in prevalence and incidence,price of biologicals,total expenditure on health,geographical access,and cost-effectiveness results)was not proven.We assume,nevertheless,that healthdeterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for IBD.In conclusion,access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors,drug prices or total health expenditure.Changes in reimbursement policy could contribute to better access to biologicals in some countries. | Fanni Rencz Márta Péntek Martin Bortlik Edyta Zagorowicz Tibor Hlavaty Andrzej Sliwczyński Mihai M Diculescu Limas Kupcinskas Krisztina B Gecse László Gulácsi Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，6： | 4 |
| 4 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 5 | Platelet actiating factor induced apoptosis is inhibited by ectopic expression of the platelet actialing factur G2 protein coupled receptor显示文摘 | Cynthia B Fanny B Paula B | 2006 | Journal of Ncurochemistry2006，82，： | 1 |
| 6 | Thalidomide in systemic mastocytosis: results from an open‐label, multicentre, phase II study显示文摘 | Bérengère Gruson Olivier Lortholary Danielle Canioni Olivia Chandesris Fanny Lanternier Julie Bruneau Bernard Grosbois Cristina Livideanu Claire Larroche Isabelle Durieu Stéphane Barete Henri Sevestre Momar Diouf Guillaume Chaby Jean‐Pierre Marolleau Patr | 2013 | Br J Haematol2013，，3： | 1 |
| 7 | Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways:role of TNF-α and MAPK显示文摘 | Fanny B Saadia KR Nathalie RL | 2004 | J Invest Dermatol2004，123，3： | 1 |
| 8 | Characterisation of sealed anodic films on 7050 T74 and 2214 T6 aluminum alloys显示文摘 | Fanny S Christlme B Georges M | 2002 | Surface and Coatings Technology2002，154，1： | 1 |
| 9 | Characterization of sealed a- nodic films on 7050 T74 and 2214 T6 aluminum alloys显示文摘 | Fanny S Christine B Georges M | 2002 | Sur- face and Coatings Technology2002，154，1： | 1 |
| 10 | c-texture versus a-texture low pressure metalorganic chemical vapor deposition ZnO films: Lower resistivity despite smaller grain size 显示文摘 | Fanni L Aebersold B A Alexander D T L | 2014 | Thin Solid Films2014，565，1： | 1 |
| 11 | Support vector machines for disruption prediction and novelty detection at JET显示文摘 | Cannas B Delogu R S Fanni A | 2007 | Fusion Engineering and Design2007，82，5： | 1 |
| 12 | River flow forecast for reservoir management through neural network显示文摘 | Baratti R Cannas B Fanni A | 2003 | Neurocompu ting2003，，： | 1 |
| 13 | Characterisation of sealed anodic films on 7050 T74 and 2214 T6 aluminium alloys 显示文摘 | Fanny S Christine B Georges M | 2002 | Surface and Coatings Technology2002，154，2： | 1 |
| 14 | River flow forecast for reservoir management through neural networks显示文摘 | BARATTI R CANNAS B FANNI A | 2003 | Neurocomputing2003，55，： | 1 |
| 15 | Platelet actiating factor-induced apoptosis is inhibited by ectopic expression of the platelet actiating factor G-protein coupled receptor显示文摘 | Cynthia B Fanny B Paula B | 2002 | J Neurochem2002，82，： | 1 |
| 16 | Evaluating the Regional Development of Border Cities by TOPSIS Model (Case Study: Sistan and Baluchistan Province, Iran)显示文摘 | Fanni Z Khakpour B Z Heydari A | 2014 | Sustainable Cities and Society2014，10，2： | 1 |
| 17 | Clinical manifestations, Laboratory findings, and therapeutic regimen in hospitalized children with brucellosis in an Iranian Referral Children Medical Centre显示文摘 | Fanni F Shahbaznejad L Pourakbari B | 2013 | J Health Popul Nutr2013，31，2： | 1 |
| 18 | Characterisation of sealed anodic films on 7050 T74 and 2214 T6 aluminium alloys显示文摘 | Fanny Snogan Christine Blanc Georges Mankowski Nadine Pébère | 2002 | Surface & Coatings Technology2002，，1： | 1 |
| 19 | Characterisation of sealed anodic films on 7050 T74 and 2214 T6 aluminium alloys 显示文摘 | Fanny S Christine B Georges M | 2002 | Surface and Coatings Technology2002，154，： | 1 |
| 20 | Follow-up of women with ASCUS in Chile Estefania L显示文摘 | Fanny L Orlando Q Trinidad B | 2011 | Diagn Cytopathol2011，39，4： | 1 |
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