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| 1 | Hypertrophic adenoids in patients with nasopharyngeal carcinoma:appearance at magnetic resonance imaging before and after treatment显示文摘Introduction:Patients with nasopharyngeal carcinoma(NPC) sporadically develop abnormal adenoids.Nasopharyngeal adenoids are usually included in the gross tumor volume(GTV) but may have different therapeutic responses than tumor tissue.Therefore,distinguishing adenoids from tumor tissue may be required for precise and efficient chemoradiotherapy and radiotherapy.We characterized nasopharyngeal adenoids and investigated the therapeutic responses of NPC and nasopharyngeal adenoids using magnetic resonance imaging(MRI).Methods:MRI data from 40 NPC patients with a coexisting adenoid mass before and after treatment were analyzed.The features of the adenoid masses,including location,striped appearance,size,interface,symmetry/asymmetry,and cysts,were evaluated.Treatment response were scored according to the World Health Organization guidelines.Results:A striped appearance was observed in 36 cases before treatment and in all cases after treatment.In these 36 cases,the average GTVs including and excluding the uninvolved adenoids were 19.8 cm^3 and 14.8 cm^3,respectively.The average percentage change after excluding the uninvolved adenoids from the GTV was 31.0%.Stable disease in the adenoids was identified in 27(96.4%) of 28 patients after neoadjuvant chemotherapy,while NPC clearly regressed.Partial adenoid responses were identified in 33(82.5%) of 40 patients at 3 months after chemoradiotherapy or radiotherapy,whereas complete tumor responses were achieved in all patients.Six months after treatment,the adenoids continued to atrophy but did not disappear,and tumor recurrence was not found.Conclusions:Nasopharyngeal adenoids and carcinoma tissue in NPC patients can be distinguished by using MRI and have different responses to chemoradiotherapy and radiotherapy.These findings contribute to better delineating the GTV of NPC,based on which spatially optimized strategies can be developed to render precise and efficient chemoradiotherapy and radiotherapy.Additionally,we observed a clear difference in the responses of these two tissue types to current therapies.This finding may reduce or avoid unnecessary biopsies or overtreatment. | Yao-Pan Wu Pei-Qiang Cai Li Tian Jie-Hua Xu Richard Alan Mitteer Jr Yi Fan Zhenfeng Zhang | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 2 | Comparative transcriptome analysis during early fruit development between three seedy citrus genotypes and their seedless mutants显示文摘Identification of genes with differential transcript abundance(GDTA)in seedless mutants may enhance understanding of seedless citrus development.Transcriptome analysis was conducted at three time points during early fruit development(Phase 1)of three seedy citrus genotypes:Fallglo(Bower citrus hybrid(Citrus reticulata×C.reticulata×C.paradisi)×Temple(C.reticulata×C.sinensis)),grapefruit(C.paradisi),Pineapple sweet orange(C.sinensis),and their seedless mutants.Seed abortion in seedless mutants was observed at 26 days post anthesis(Time point 2).Affymetrix transcriptomic analysis revealed 359 to 1077 probe sets with differential transcript abundance in the comparison of seedless versus seedy fruits for each citrus genotypes and time points.The GDTA identified by 18 microarray probe sets were validated by qPCR.Hierarchical clustering analysis revealed a range of GDTA associated with development,hormone and protein metabolism,all of which may reflect genes associated with seedless fruit development.There were 14,9 and 12 genes found exhibiting similar abundance ratios in all three seedless versus seedy genotype comparisons at time point 1,2 and 3,respectively.Among those genes were genes coding for an aspartic protease and a cysteine protease,which may play important roles in seedless fruit development.New insights into seedless citrus fruit development may contribute to biotech approaches to create seedless cultivars. | Shujian Zhang Qingchun Shi Ute Albrecht Robert G Shatters Jr Ric Stange Greg McCollum Shuo Zhang Chengming Fan Ed Stover | 2017 | Horticulture Research2017，4，1： | 2 |
| 3 | Differences in the effects of HMG-CoA reductase inhibitors on proliferation and viability of smooth muscle cells in culture显示文摘 | Sindermann JR Fan L Weigel KA | 2000 | Atherosclerosis2000，150，2： | 1 |
| 4 | Numerical simulation of inhaled aerosol particle deposition within 3D realistic human upper respiratory tract 显示文摘 | Lin J Fan JR Zheng YQ | 2010 | AIP Conference Proceedings2010，1207，： | 1 |
| 5 | Functional roles of E2F in cell cycle regulation 显示文摘 | Fan J Bertino JR | 1997 | Oncogene1997，14，10： | 1 |
| 6 | Experimental measurements of dosimetric parameters on the transverse axis of a new 125I source显示文摘 | Li Z Fan J J Palta JR | | 0，，06： | 1 |
| 7 | Forced expression of the homeobox-containing gene Pem blocks differentiation of embryonic stem cells显示文摘 | Fan Y Melhem MF Chaillet JR | 1999 | Dev Biol1999，210，2： | 1 |
| 8 | Fluorescent conjugated polymer molecular wire chemosensors for transition metal ion recognition and signaling显示文摘 | Fan L J Zhang Y Wayne E Jones Jr | 2009 | Coordination Chemistry Reviews2009，253，34： | 1 |
| 9 | Function roles of E2F in cell cycle regu- lation显示文摘 | Fan J Bertino JR | 1997 | Oncogene1997，14，10： | 1 |
| 10 | Using quality of life to predict hos- pitalization and mortality in patients with obstructive lung diseases 显示文摘 | Fan VS Curtis JR Tu SP | 2002 | Chest2002，122，42： | 1 |
| 11 | Thermal and Alkaline Denaturation of Bovine fI-Casein显示文摘 | Qi P x Wickham E D Fan'ell Jr H M | 2004 | The Protein Journal2004，23，6： | 1 |
| 12 | Using quality of life to predict hospitalization and mortality in patients with obstructive lung diseases 显示文摘 | Fan VS Curtis JR Tu SP | 2002 | Chest2002，122，2： | 1 |
| 13 | Large eddy simulation of inhaled particle deposition within the human upper respiratory tract 显示文摘 | Jin HH Fan JR Zeng MJ | 2007 | Journal of aerosol Science (S0021-8502)2007，38，3： | 1 |
| 14 | DLIA,a novel Notch ligand ex- pressed in arterial endothelium显示文摘 | Shutter JR Scully S Fan W | 2000 | Genes Dev2000，14，11： | 1 |
| 15 | Interferon-gamma protects primary monocytes against infection with human immunodeficiency virus type 1显示文摘 | Fan SX Turpin JA Aronovitz JR | 1994 | J Leukoc Biol1994，56，： | 1 |
| 16 | Antibiotic prophylaxis for patients undergoing elective endoscopic retrograde 显示文摘 | Brand M Bizos D O' Fan'ell P Jr | 2010 | Cochrane Database Syst Rev2010，6，00： | 1 |
| 17 | Age variation of torma- tion stages for ten permanent teeth 显示文摘 | Moorrees C F Fanning E A Hunt E E Jr | 1963 | J Dent Res1963，42，： | 1 |
| 18 | Using quality of life to predict hospitalization and mortality in patients with obstructive lung diseases显示文摘 | Fan VS Curtis JR Tu SP | 2002 | Chest2002，122，2： | 1 |
| 19 | Reoperative coronary artery bypass grafting without cardiopulmonary bypass显示文摘 | Fanning WJ Kakos GS Williams TE Jr | 1993 | Ann Tharsc Sury1993，55，2： | 1 |
| 20 | Overexpression of histidine-rich Ca-binding protein protects against ischemia/reperfusion-induced cardiac injury显示文摘 | Zhou CC Fan X Ren JR | 2007 | Cardiovasc Res2007，75，3： | 1 |
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