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| 1 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 2 | Planar morphology and controlling factors of the gullies in the Yuanmou Dry-hot Valley based on field investigation显示文摘The plane form of a gully can provide a basis for evaluating the gully volume and erosion rate, acting process, and evolutionary stage. For describing the planar characteristics of a permanent gully and understanding their controlling factors, this study, utilizing a total station and GPS RTK, measured the shoulder lines and channel curves of 112 gullies in six sites of the Yuanmou Dry-hot Valley and then mapped them by Arc GIS software and calculated nine parameters. The results showed that the channel lengths range from 10.88 to 249.11 m; the widths range from 6.20 to 40.99 m; the perimeters range from 54.11 to 541.67 m; the gully areas range from 153.02 to 6,930.30 m2; the left-side areas range from 92.93 to 4,027.20 m2; and the right-side areas range from 63.65 to 3,539.77 m2. The slightly sinuous and straight gullies account for 73.21% of the total gullies; the quantity of the right skewed gullies is 8.93% greater than that of the left skewed ones based on the symmetry ratio; the shape ratios range from 1.12 to 1.40 and the morphology ratios from 0.038 to 1.294; the fractal dimension is 1.192. Gullies in different sites have diverse planar characteristics. Except for the symmetry index, which was close to a negatively skewed distribution, all of the other parameters had the characteristic of positively skewed distribution. The gully area is related to the length and width, but the gully length has a weak correlation with the width. The evolutionary stage, topographic conditions, strata, soil properties, and piping erosion played very important roles in the gully planar morphology. This study could provide useful information for controlling gully erosion and safeguarding human habitation and engineering buildings. | DENG Qingchun MIAO Fang ZHANG Bin LUO Mingliang LIU Hui LIU Xiaojiao QIN Fachao LIU Gangcai | 2015 | Journal of Arid Land2015，7，6： | 3 |
| 3 | Endoscopic sphincterotomy plus balloon dilation versus endoscopic sphincterotomy for choledocholithiasis: A meta‐analysis显示文摘 | Yangyang Liu Peizhu Su Yinghao Lin Siheng Lin Kun Xiao Pingyan Chen Shengli An Yang Bai Fachao Zhi | 2013 | J Gastroenterol Hepatol2013，，6： | 2 |
| 4 | Research on the 3PL Supplier Selection Based on Set-Val- ued Satisfaction显示文摘 | Fachao Li Ling Li Chenxia Jin Ruijiang Wang Hong Wang | 2012 | Computers and Operations Research2012，39，8： | 1 |
| 5 | Fuzzy metric and convergences based on the symmetric difference 显示文摘 | Wu Congxin Li Fachao | 1999 | Fuzzy Sets ana Systems1999，108，3： | 1 |
| 6 | The completeness for p-mean symmetric difference metric 显示文摘 | Li Fachao Qiu Jiqing Zhai Jianren | 2000 | Fuzzy Sets and Systems2000，116，3： | 1 |
| 7 | A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block “eat-me” signal显示文摘Immune checkpoint inhibitors(ICIs)have induced durable clinical responses in a subset of patients with colorectal cancer(CRC).However,the dis-satisfactory response rate and the lack of appropriate biomarkers for selecting suitable patients to be treated with ICIs pose a major challenge to current immunotherapies.Inflammation-related molecule A20 is closely related to cancer immune response,but the effect of A20 on“eat-me”signal and immunotherapy efficacy remains elusive.We found that A20 downregulation prominently improved the antitumor immune response and the efficacy of PD-1 inhibitor in CRC in vitro and in vivo.Higher A20 expression was associated with less infiltration of immune cells including CD3(+),CD8(+)T cells and macrophages in CRC tissues and also poorer prognosis.Gain-and loss-A20 functional studies proved that A20 could decrease the“eat-me”signal calreticulin(CRT)protein on cell membrane translocation via upregulating stanniocalcin 1(STC1),binding to CRT and detaining in mitochondria.Mechanistically,A20 inhibited GSK3βphosphorylating STC1 at Thr86 to slow down the degradation of STC1 protein.Our findings reveal a new crosstalk between inflammatory molecule A20 and“eat-me”signal in CRC,which may represent a novel predictive biomarker for selecting CRC patients most likely to benefit from ICI therapy. | Min Luo Xueping Wang Shaocong Wu Chuan Yang Qiao Su Lamei Huang Kai Fu Sainan An Fachao Xie Kenneth Kin Wah To Fang Wang Liwu Fu | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 1 |
| 8 | Endoscopic sphincterotomy plus balloon dilation versus endoscopic sphincterotomy for choledocholithiasis: A meta‐analysis显示文摘 | Yangyang Liu Peizhu Su Yinghao Lin Siheng Lin Kun Xiao Pingyan Chen Shengli An Yang Bai Fachao Zhi | 2013 | J Gastroenterol Hepatol2013，，6： | 1 |
| 9 | Finite element analysis of a bus skeleton and structure im-provement 显示文摘 | JIANG Fachao FAN Yuezhen LIU Entuo | 2013 | Adv Intell Syst Comput2013，180，： | 1 |
| 10 | Software design of engine characteristic simulation 显示文摘 | JIANG FACHAO WANG MOLIN L1 LIN | 2012 | Journal of Software2012，7，2： | 1 |
| 11 | Clinicopathologic features and endoscopic mucosal resection of laterally spreading tumors: experience from China显示文摘 | Yinglong Huang Side Liu Wei Gong Fachao Zhi Deshou Pan Bo Jiang | 2009 | International Journal of Colorectal Disease2009，，： | 1 |
| 12 | The morphological characteristics of gully systems and watersheds in Dry-Hot Valley, SW China显示文摘Gully systems and watersheds are geomorphic units with clear boundaries that are relatively independent of basin landscapes and play an important role in natural geography. In order to explore the morphological characteristics of gully systems and watersheds in the Dry-Hot Valley [South West(SW) China], gullies are interpreted from online Google images with high resolution and watersheds are extracted from digital elevation model at a scale of 1:50,000. The results show that:(1) There are17,382 gullies(with a total area of 1141.66 km2) and 42 watersheds in the study area.(2) The average gully density of the study area(D) is 4.29 km/km2, gully frequency(F) is 14.39 gullies/km2, the branching ratio(B) is 5.13, the length ratio(L) is 3.12, and the coefficient of the main and tributary gullies(M) is 0.06. The degree of gully erosion isstrong to extremely strong, the main development intensity of gully erosion ranges from intense to moderate, and the type of gully system is tributary.(3) The watershed areas(A) are between 0.39 and 96.43 km2, the relief ratio(R) is from 0.10 to 0.19, the circularity ratio(C) is from 0.30 to0.83, the texture ratio(T) is from 0.82 to 39.35, and the dominant geomorphological texture type is fine.(4) There is a quantitative relationship between F and D:F = 0.624 D2(R =0.84) and T is closely related to D, F, M(R2[ 0.7). A,R and C are related to M(R2[ 0.5). The development of gully systems is the result of coupling effects between multiple factors. In this area, the degree of erosion and the condition of the main and tributary gullies can be controlled by the degree of topographic breakage in the watershed, which provides some theoretical basis for the evaluation of gully erosion by the latter. In addition, the scale, relief, and shape have a significant impact on the locations of the main and tributary gullies. For tributary gullies, attention should be paid to the interception and control of runoff and sediment in the small confluence branches in order to prevent gully expansion and head advance. These features can inform the development of targeted measures for the control of soil erosion. | Zhen Xu Fachao Qin Bin Zhang Qingchun Deng Hui Liu Jie Jin Liangtao Shi | 2018 | Acta Geochimica2018，37，6： | 1 |
| 13 | Thermal degradation and flame retardance of epoxy resins containing a microencapsulated flame retardant显示文摘 | Ming Gao Weihong Wu Fachao Wu | 2012 | Journal of Vinyl and Additive Technology2012，18，1： | 1 |
| 14 | Fuzzy metric and convergences based on the symmetric difference 显示文摘 | Wu Congxin LI Fachao | 1999 | Fuzzy Sets ana Systems1999，108，3： | 1 |
| 15 | Intelligent Bionic Genetic Algorithm (IB-GA) and its convergence显示文摘 | Li Fachao Xu Lida Jin Chenxia | 2011 | Expert Systems with Applications2011，38，7： | 1 |
| 16 | Confirmation of three inflammatory bowel disease susceptibility loci in a Chinese cohort显示文摘 | Chaolan Lv Xiaoming Yang Yiyang Zhang Xinmei Zhao Zhengyan Chen Jinghua Long Yingchun Zhang Changqing Zhong Jia Zhi Guopeng Yao Bo Jiang Fachao Zhi | 2012 | International Journal of Colorectal Disease2012，，11： | 1 |
| 17 | A few measures for ensuring supply chain quality显示文摘 | Li Zhang Wang Song Li Fachao | | 0，，01： | 1 |
| 18 | Finite element analysis of a bus skeleton and structure im-provement 显示文摘 | JIANG Fachao FAN Yuezhen LIN Entuo | 2013 | Adv Intell Sys Comput2013，180，： | 1 |
| 19 | Recurrence and surveillance of colorectal adenoma after polypectomy in a southern Chinese population显示文摘 | Yinglong Huang Wei Gong Bingzhong Su Fachao Zhi Side Liu Yang Bai Bo Jiang | 2010 | Journal of Gastroenterology2010，，8： | 1 |
| 20 | A generalized fuzzy ID3 algorithm using generalized information entropy显示文摘 | JIN CHENXIA LI FACHAO LI YAN | 2014 | Knowledgebased Systems2014，64，7： | 1 |
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