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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Mature results of PulmonArt:Involved-field 3D radiotherapy(RT)and docetaxel/ cisplatin chemotherapy(CT)in a randomised phase 2 study comparing concurrent CT-RT followed by consolidation CT, with induction CT followed by concurrent CT-RT in patients(pts)with stage III non-small cell lung cancer(NSCLC): B5-06 显示文摘 | van Meerbeeck JP Felipe C Johan V | 2007 | J Thorac Oncol2007，2，8： | 1 |
| 3 | Corporate so-cial responsibility, firm value and financial performance inBrazil显示文摘 | VICENTE L C FREIRE F S FELIPE C V | 2011 | Social Responsibility Journal2011，7，2： | 1 |
| 4 | Growth, feed efficiency and condition of common Octopus fed two formulated moist diets显示文摘 | Jesus C V Maria D H Felipe A G | 2008 | Aquaculture2008，275，： | 1 |
| 5 | Site-specific release of nascent chains from ribosomes at a sense codon显示文摘 | Doronina V A Wu C de Felipe P | | 0，，13： | 1 |
| 6 | Oxidative stress and enzymatic antioxidant mechanisms in essential hypertension显示文摘 | Guillermo Saez Maria C Tormos Vicente Giner Jose V Lozano Felipe J Chaves Maria E Armengod Josep Redon | 2001 | American Journal of Hypertension2001，，4： | 1 |
| 7 | An algorithm for fast optimal Latin hypercube design of experiments显示文摘 | Felipe A C Gerhard V Vladimir B | 2010 | Numerical Methods in Engineering2010，82，2： | 1 |
| 8 | Site-specific release of nascent chains from ribosomes at a sense codon显示文摘 | Doronina V A Wu C De Felipe P | | 0，，13： | 1 |
| 9 | Site-specific re- lease of nascent chains from ribosomes at a sense eodon显示文摘 | Dmvnina V A Wu C de Felipe P | 2008 | Mol Cell Biol2008，28，13： | 1 |
| 10 | Extraction by reversed micelles of the intrecellular enzyme xylose reductase 显示文摘 | Cortez E V Almeida Felipe M G Roberto 1N C | 2001 | Applied Biochemistry and Biotech- nology2001，91，19： | 1 |
| 11 | Modified Avrami Expression for Polymer Crystallization Kinetics 显示文摘 | Fernando C P Felipe D C Ricardo V G | 1991 | J Appl Polym Sci1991，43，： | 1 |
| 12 | Chronic renal failure in pediatrics1996显示文摘 | Edda L Anita V Felipe C | 1999 | Pediatr Nephrol1999，13，： | 1 |
| 13 | Pilocarpine-induced Seizures in Adult Rats: Monoamine Content and Muscarinic and Dopaminergic Receptor Changes in the Striatum 显示文摘 | Freitas R M Bezerra Felipe C F Nascimento V S | 2003 | Comp Biochem Physiol C Toxicol Pharmacol2003，136，2： | 1 |
| 14 | Mature results of Pul-monArt:Involved-field 3D diotherapy (RT)and docetaxel/cisplatinchemotherapy (CT)in a randomised phase 2 study comparing concur-rent CT-RT followed by consolidation CT, with induction CT fol-lowed by concurrent CT-RT in patients (pts)with stage III non-smallcell lung cancer(NSCLQ: B5-06显示文摘 | Van Meerbeeck JP Felipe C Johan V | 2007 | Thorac Oncol2007，，8： | 1 |
| 15 | Dimensions of emotional distress among Brazilian workers in a COVID-19 reference hospital:A factor analytical study显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic is an unprecedented challenge for public health and has caused the loss of millions of lives worldwide.Hospital workers play a key role in averting the collapse of the health system,but the mental health of many has deteriorated during the pandemic.Few studies have been devoted to identifying the needs of workers on frontline duty.AIM To investigate dimensions of common emotional symptoms and associated predictors among Brazilian workers in a COVID-19 reference hospital.METHODS This is an observational study of the mental health of professionals in a COVID-19 hospital in the city of São Paulo.We invited all hospital employees to respond to an online survey between July and August 2020,during the first peak of the pandemic.Data of 1000 participants who completed the survey were analyzed(83.9%were women and 34.3%were aged 30 to 40).Hospital workers selfreported the presence of symptoms of depression,anxiety,trauma-related stress,and burnout through the Patient Health Questionnaire-9,the Generalized Anxiety Disorder-7,the Impact of Event Scale-Revised and the Mini-Z Burnout Assessment respectively.Responses were assembled and subjected to exploratory factor analysis to reveal workers’core emotional distress.Multiple linear regression models were subsequently carried out to estimate the likelihood of dimensions of distress using questions on personal motivation,threatening events,and institutional support.RESULTS Around one in three participants in our sample scored above the threshold of depression,anxiety,post-traumatic stress disorder,and burnout.The factor analysis revealed a three-factor structure that explained 58%of the total data variance.Core distressing emotional domains were avoidance and re-experience,depression-anxiety,and sleep changes.Regression analysis revealed that institutional support was a significant protective factor for each of these dimensions(βrange=-0.41 to-0.20,P<0.001).However,participants’personal motivation to work in healthcare service was not associated with these emotional domains.Moreover,the likelihood of presenting the avoidance and re-experience dimension was associated with having a family member or close friend be hospitalized or die due to COVID-19 and having faced an ethical conflict.CONCLUSION Distressing emotional domains among hospital workers were avoidance and re-experience,depression and anxiety,and sleep changes.Improving working conditions through institutional support could protect hospital workers'mental health during devastating public health crises. | Marcos O Carvalho-Alves Vitor A Petrilli-Mazon Andre R Brunoni Andre Malbergier Pedro Fukuti Guilherme V Polanczyk Euripedes C Miguel Felipe Corchs Yuan-Pang Wang | 2022 | World Journal of Psychiatry2022，12，6： | 0 |
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