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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Serum S100beta: a noninvasive marker of blood-brain barrier function and brain lesions 显示文摘 | Kanner AA Marchi N Fazio V | 2003 | Cancer2003，97，11： | 1 |
| 3 | Loss of flow induces leukocyte - mediated MMP/TIMP imbalance in dynamic in vitro blood - brain barrier model : role of pro - inflammatory cytokines显示文摘 | Krizanac - Bengez L Hossain M Fazio V | 2006 | Am J Physiol Cell Physiol2006，291，4： | 1 |
| 4 | Serum transthyretin monomer as a possible marker of blood-to-csf barrier disruption显示文摘 | Marchi N Fazio V Cucullo L | 2003 | J Neurosci2003，23，5： | 1 |
| 5 | A microsecond-pulse length,frequency-stabilized virtual-cathode oscillator using a resonant cavity显示文摘 | Fazio M V Freeman B L Hoeberlin R L | 1992 | IEEE Trans on Plasma Sci1992，20，3： | 1 |
| 6 | Serum s100beta:a noninvasive maker of blood-brain barrier function and brain lesions显示文摘 | KANNER AA MARCHI N FAZIO V | 2003 | Cancer2003，97，11： | 1 |
| 7 | Serum S100 beta:a noninvasive marker of blood-brain barrier function and brain lesion显示文摘 | Kanner AA Marchi N Fazio V | 2003 | Cancer2003，97，11： | 1 |
| 8 | RLIP76, a non-ABC transporter, and drug resistance in epilepsy显示文摘 | Awasthi S Hallene KL Fazio V | 2005 | BMC Neurosci2005，6，27： | 1 |
| 9 | Uhracompact pulsed power显示文摘 | Fazio M V Kirbie H C | 2004 | Proceedings of the IEEE Pulsed Power: Technology and Applications2004，92，7： | 1 |
| 10 | Serum S100 beta: a noninvasive marker of blood-brain barrier function and brain lesions 显示文摘 | Kanner AA Marchi N Fazio V | 2003 | Cancer2003，97，11： | 1 |
| 11 | A microsecond-pulse length, frequency-stabilized virtual-cathode oscillator using a resonant cavity显示文摘 | Fazio M V Freeman B L Hoeberlin R | 1992 | IEEE1992，20，3： | 1 |
| 12 | Loss of flow induces leukocyte-mediated MMP/TIMP imbalance in dynamic in vitro blood brain barrier model role of pro-inftamrnatotry eytokines 显示文摘 | Krizanac-Bengez L Hossain M Fazio V | 2006 | Am J Physiol Cell Physio12006，291，4： | 1 |
| 13 | A 500 MW, 1 μs pulse length high current relative klystron显示文摘 | Fazio M V Haynes W B Carlsten B E | 1994 | IEEE1994，22，5： | 1 |
| 14 | Peripheral markers of blood-brain barrier damage显示文摘 | Marchi N Cavaglia M Fazio V | 2004 | Clin Chim Acta2004，342，12： | 1 |
| 15 | Serum S-100 beta:a non-invasive marker of blood-brain barrier function and brain lesion 显示文摘 | Kanner AA Marchi N Fazio V | 2003 | Cancer2003，97，11： | 1 |
| 16 | Bile analysis of drugs in postmortem cases 显示文摘 | Vanbinst R Koenig J Di Fazio V | 2002 | Forensic Sci Int2002，128，12： | 1 |
| 17 | Helicobacter pylori and atrial fibrillation :absence of correlations显示文摘 | Lunetta M Fazio G Avena V | 2009 | J Cardiovasc Med2009，10，1： | 1 |
| 18 | Serum S100beta : A noninva- sive maker of blood - brain barrier function and brain lesions 显示文摘 | Kanner A A Marchi N Fazio V | 2003 | Cancer2003，97，11： | 1 |
| 19 | Lass of flow induces leukocyte-mediated MMP/TIMP imbalance in dynamic in vitro blood-brain barrier model:role of pro-inflammatory cytokines显示文摘 | Krizanac- BengezL Hossain M Fazio V | 2006 | Am J Physiol Cell Physiol2006，291，4： | 1 |
| 20 | Beam-cavity ineraction physics for middly relativistic,intense-beam klystron amplifier显示文摘 | Carlsten B E Faehl R J Fazio M V | | 0，，05： | 1 |
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