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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Evaluation of the thoracolumbar injury classification system in thoracic and lumbar spinal trauma显示文摘 | JOAQUIM A F FERNANDES Y B CAVALCANTE RA | 2011 | Spine(Phila Pa 1976)2011，36，1： | 1 |
| 3 | Mathematical model coupling phase transformation and temperature evolution during quenching of steels显示文摘 | Fernandes F M B Denis S Simon A | 1984 | Materials Science and Technology1984，1，10： | 1 |
| 4 | Landslides in Rio de Janeiro: The role played by variations in soil hydraulic conductivity显示文摘 | VIEIRA B C FERNANDES N F | 2004 | I-Iydrologieal Processes2004，，18： | 1 |
| 5 | Isola- tion and characterization of a Pseudomonas aeruginosa from a virgin Brazilian Amazon region with potential to degrade a- trazine显示文摘 | Fernandes A F T da Silva M B P Martins V V | 2014 | Environmental Science and Pollution Research2014，21，13： | 1 |
| 6 | Characterization and kinetic compensation effect of corn biodiesel显示文摘 | DANTAS M B ALMEIDA A A F CONCEICAO M M FERNANDES V J Jr SANTOS I M G SILVA F C SOLEDADE L F B SOUZA A G | 2007 | J Therm Anal Calorim2007，87，3： | 1 |
| 7 | Mathematical model coupling phased transformation and temperature evolution dur- ing quenching of steels 显示文摘 | Fernandes F M B Denis S Simon A | 1985 | Materials Science and Technolo- gy1985，1，10： | 1 |
| 8 | Mathematical Model Coupling Phase Transformation and Temperature Evolution During Quenching of Steels显示文摘 | Fernandes F M B Denis S Simon A | 1985 | Materials Science and Technology1985，1，10： | 1 |
| 9 | Interspe- cies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles 显示文摘 | Gaiser B K Fernandes T F Jepson M A | 2012 | Environmental Toxicolo- gy and Chemistry2012，31，1： | 1 |
| 10 | Effects of ergothioneine from mushrooms (Flammulina velutipes) on melanosis and lipid oxidation of kuruma shrimp (Marsupenaeus japonicus)显示文摘 | ANGEL B E FERNAND F IKUO H | | 0，，： | 1 |
| 11 | Sebaceous carcinoma of the eyelid显示文摘 | Fernandes B F Martins C M Heckler L V Arthurs B Codere F Burnier M N Jr | 2009 | ANZ J Surg2009，79，： | 1 |
| 12 | Thermodynamie modeling of the Nb-Si systeml显示文摘 | Fernandes P B Coelho G C Ferreira F | 2002 | Intermetallies2002，10，： | 1 |
| 13 | Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats显示文摘 | FLORES M B FERNANDES M F ROPELLE E R | 2006 | Diabetes2006，55，9： | 1 |
| 14 | 查看详情显示文摘 | M G Freire L M N B F Santos A M Fernandes | | 0，，1： | 1 |
| 15 | Quinolone alkaloids from Zanthoxylum acutifolium 显示文摘 | ARRUDA S P M FERNANDES B J SILVE M F G F | 1992 | Phytochemistry1992，31，10： | 1 |
| 16 | Bioactive extracts of red seaweeds Pterocladiella capillacea and Osmundaria obtusiloba(Floridophyceae:Rhodophyta) with antioxidant and bacterial agglutination potential显示文摘Objective:To evaluate the antioxidant,antibacterial and bacterial cell agglutination activities of the hexane(Hex) and 70%ethanol(70%EtOH) extracts of two species of red seaweeds Pterocladiella capillacea(P.capillacea) and Osmundaria obtusiloba.Methods:In vitro antioxidant activity was determined by DPPH radical scavenging assay,ferric-reducing antioxidant power assay,ferrous ion chelating assay,β-carotene bleaching assay and total phenolic content quantification.Antimicrobial activity was tested using the method of disc diffusion on Mueller-Hinton medium.The ability of algal extracts to agglutinate bacterial cells was also tested.Results:The 70%EtOH extract of the two algae showed the highest values of total phenolic content compared to the Hex extract.The results of DPPH for both extracts(Hex,70%EtOH) of Osmundaria obtusiloba(43.46%and 99.47%) were higher than those of P.capillacea(33.04%and 40.81%) at a concentration of 1 000 μg/mL.As for the ferrous ion chelating,there was an opposite behavior,extracts of P.capillacea had a higher activity.The extracts showed a low ferric-reducing antioxidant power,with optical density ranging from0.054 to 0.180.Antioxidant activities of all extracts evaluated for β-carotene bleaching were above 40%.There was no antibacterial activity against bacterial strains tested.However,the extracts of both species were able to agglutinate bacterial Gram positive cells of Staphylococcus aureus and Gram negative cells of Escherichia coli,multidrug-resistant Salmonella and Vibrio harveyi.Conclusions This is the first report of the interaction between these algal extracts,rich in natural compounds with antioxidant potential,and Gram positive and Gram negative bacterial cells. | Daniel Barroso de Alencar Fátima Cristiane Teles de Carvalho Rosa Helena Rebouas Daniel Rodrigues dos Santos Kelma Maria dos Santos Pires-Cavalcante Rebeca Larangeira de Lima Bárbara Mendes Baracho Rayssa Mendes Bezerra Francisco Arnaldo Viana Regine Helena Silva dos Fernandes Vieira Alexandre Holanda Sampaio Oscarina Viana de Sousa Silvana Saker-Sampaio | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 1 |
| 17 | Cold-induced repres- sion of the rice anther-specific cell wall invertase gene OSINV4 is correlated with sucrose accumulation and pollen sterility 显示文摘 | Oliver S N Van Dongen J T Alfred S C Mamun E Zhao X Saini H S Fernandes S F Blanchard C L Sutton B Gelgenberger P Dennis E Dolferus R | 2005 | Plant Cell &Environment2005，28，： | 1 |
| 18 | Evaluation of Al/SiC wetting characteristics in functionally graded metal-matrix composite by synchrotron radiation microtomography显示文摘 | R Martins F B Fernandes A Velhinho | 2003 | Materials Science Forum2003，，： | 1 |
| 19 | Thermodynamic modeling of the Nb-Si system显示文摘 | FERNANDES P B COELHO G C FERREIRA F NUNES C A SUNDMAN B | 2002 | Intermetallics2002，10，： | 1 |
| 20 | Verification of the feasibility of autogenous testis implant in omentum and abdominal wall in mice 显示文摘 | Nunes S I Fernandes C B Rezende D F | 2013 | Rev Col Bras Cir2013，1，40： | 1 |
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