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| 1 | 【特刊综述】骨骼两性异形中的雄激素和雌激素显示文摘骨骼是表达雄激素、雌激素受体以及类固醇代谢酶的一种内分泌组织。循环性激素的生物活性通过六种性激素结合球蛋白以及在骨组织中的局部转变来进行调节,例如,睾酮通过芳香酶转变成雌二醇,或通过5α还原酶转变成双氢睾酮。由于高分辨外周CT应用的增多,我们对造成骨骼强度性别差异的结构基础的认识在近几年有很大进步。这些对微小结构的观察是理解性激素对男性峰值骨量及对骨皮质和骨小梁之间转变的影响的基础。最近的研究利用Cre/LoxP技术使我们在整体基因敲除小鼠上机械的认识精确到性激素及其在成骨细胞、破骨细胞、骨细胞以及其它造成男性骨质疏松的细胞上的核受体的直接作用。同时,这些研究加强了这样的观点:雄激素和雌激素的缺乏通过与例如胰岛素样生长因子1、炎症、氧化应激、骨骼代谢的中枢神经系统控制、机械负荷的适应等的交互作用发挥直接和多种效应。这篇综述将总结性激素在男性骨骼自身平衡作用这个领域有关方面最近的进展。 | Michael Laurent Leen Antonio Mieke Sinnesael Vanessa Dubois Evelien Gielen Frank Classens Dirk Vanderschueren | 2014 | Asian Journal of Andrology2014，16，2： | 4 |
| 2 | N-alkylamide profiling of Achillea ptarmica and Achillea millefolium extracts by liquid and gas chromatography–mass spectrometry显示文摘Achillea millefolium and Achillea ptarmica are both plants belonging to the Asteracea family and are traditionally used for their medicinal properties. It has already been shown that some N-alkylamides(NAAs)are responsible for these pharmacological actions. Therefore, in the present study, the NAA content of the two plants was analytically characterised. Different extracts were prepared from the roots, the leaves, the stems and the flowers. The structures of NAAs have been assigned in ethanolic extracts of Achillea millefolium and Achillea ptarmica using high performance liquid chromatography – electrospray ionisation – mass spectrometry(HPLC–ESI–MS) and gas chromatography – electron impact – mass spectrometry(GC–EI–MS). Using both analytical techniques, the structures of 14 and 15 NAAs have been assigned in Achillea ptarmica and Achillea millefolium, respectively. Structures of two new NAAs, previously never observed in Achillea ptarmica,were assigned: deca-2E,6Z,8E-trienoic acid 2-methylbutylamide(homospilanthol) or a related isomeric compound and deca-2E,4E-dienoic acid N-methyl isobutylamide. The structure of homospilanthol or a related isomeric compound was also assigned in Achillea millefolium for the first time. | Lieselotte Veryser Lien Taevernier Evelien Wynendaele Yannick Verheust Ann Dumoulin Bart De Spiegeleer | 2017 | Journal of Pharmaceutical Analysis2017，7，1： | 3 |
| 3 | Clinical use of dendritic cells for cancer therapy显示文摘 | Sébastien Anguille Evelien L Smits Eva Lion Viggo F van Tendeloo Zwi N Berneman | 2014 | Lancet Oncology2014，，7： | 3 |
| 4 | Adenoma detection with cap-assisted colonoscopy versus regular colonoscopy: a randomised controlled trial显示文摘 | Thomas R de Wijkerslooth Esther M Stoop Patrick M Bossuyt Elisabeth M H Mathus-Vliegen Jan Dees Kristien M A J Tytgat Monique E van Leerdam Paul Fockens Ernst J Kuipers Evelien Dekker | 2012 | Gut2012，，10： | 3 |
| 5 | Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline显示文摘 | Cesare Hassan Enrique Quintero Jean-Marc Dumonceau Jaroslaw Regula Catarina Brand?o Stanislas Chaussade Evelien Dekker Mario Dinis-Ribeiro Monika Ferlitsch Antonio Gimeno-García Yark Hazewinkel Rodrigo Jover Mette Kalager Magnus Loberg Christian Pox Bjorn | 2013 | Endoscopy2013，，10： | 3 |
| 6 | Reversed-phase fused-core HPLC modeling of peptides显示文摘Different fused-core stationary phase chemistries(C18,Amide,Phenyl-hexyl and Peptide ES-C18) were used for the analysis of 21 structurally representative model peptides.In addition,the effects of the mobile phase composition(ACN or MeOH as organic modifier;formic acid or acetic acid,as acidifying component) on the column selectivity,peak shape and overall chromatographic performance were evaluated.The RP-amide column,combined with a formic acid-acetonitrile based gradient system,performed as best.A peptide reversed-phase retention model is proposed,consisting of 5 variables:log SumAA,log Sv,clog P,log nHDon and log nHAcc.Quantitative structure-retention relationship(QSRR) models were constructed for 16 different chromatographic systems.The accuracy of this peptide retention model was demonstrated by the comparison between predicted and experimentally obtained retention times,explaining on average 86% of the variability.Moreover,using an external set of 5 validation peptides,the predictive power of the model was also demonstrated.This peptide retention model includes the novel in-silico calculated amino acid descriptor,AA,which was calculated from log P,3D-MoRSE,RDF and WHIM descriptors. | Matthias D'Hondt Bert Gevaert Sofie Stalmans Sylvia Van Dorpe Evelien Wynendaele Kathelijne Peremans Christian Burvenich Bart De Spiegeleer | 2013 | Journal of Pharmaceutical Analysis2013，3，2： | 3 |
| 7 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 8 | Protein energy malnutrition predicts complications in liver cirrhosis显示文摘 | Ellen J. Huisman Evelien J. Trip Peter D. Siersema Bart van Hoek Karel J. van Erpecum | 2011 | European Journal of Gastroenterology & Hepatology2011，，11： | 2 |
| 9 | Random Comparison of Guaiac and Immunochemical Fecal Occult Blood Tests for Colorectal Cancer in a Screening Population显示文摘 | Leo G. van Rossum Anne F. van Rijn Robert J. Laheij Martijn G. van Oijen Paul Fockens Han H. van Krieken Andre L. Verbeek Jan B. Jansen Evelien Dekker | 2008 | Gastroenterology2008，，1： | 2 |
| 10 | Endoscopic Trimodal Imaging Detects Colonic Neoplasia as Well as Standard Video Endoscopy显示文摘 | Teaco Kuiper Frank J.C. van den Broek Anton H. Naber Ellert J. van Soest Pieter Scholten Rosalie Ch. Mallant–Hent Jan van den Brande Jeroen M. Jansen Arnoud H.A.M. van Oijen Willem A. Marsman Jacques J.G.H.M. Bergman Paul Fockens Evelien Dekker | 2011 | Gastroenterology2011，，7： | 2 |
| 11 | Endoscopic features of sessile serrated adenomas: validation by international experts using high-resolution white-light endoscopy and narrow-band imaging显示文摘 | Yark Hazewinkel Maria López-Cerón James E. East Amit Rastogi Maria Pellisé Takeshi Nakajima Susanne van Eeden Kristien M.A.J. Tytgat Paul Fockens Evelien Dekker | 2013 | Gastrointestinal Endoscopy2013，，6： | 2 |
| 12 | Training and transfer of colonoscopy skills: a multinational, randomized, blinded, controlled trial of simulator versus bedside training显示文摘 | Adam Haycock Arjun D. Koch Pietro Familiari Foke van Delft Evelien Dekker Lucio Petruzziello Jelle Haringsma Siwan Thomas-Gibson | 2010 | Gastrointestinal Endoscopy2010，，2： | 2 |
| 13 | Dendritic cells in the pathogenesis and treatment of human diseases: a Janus Bifrons?显示文摘 | Nathalie Cools Annacarmen Petrizzo Evelien Smits Franco M Buonaguro Maria L Tornesello Zwi Berneman Luigi Buonaguro | 2011 | Immunotherapy2011，，10： | 2 |
| 14 | Analytical quality-by-design approach for sample treatment of BSA-containing solutions显示文摘The sample preparation of samples conlaining bovine serum albumin(BSA),e.g..as used in transdermal Franz diffusion cell(FDC) solutions,was evaluated using an analytical qualily-by-design(QbD)approach.Traditional precipitation of BSA by adding an equal volume of organic solvent,often successfully used with conventional HPLC-PDA,was found insufficiently robust when novel fused-core HPLC and/or UPLC-MS methods were used.In this study,three factors(acetonitrile(%).formic acid(%) and boiling time(min)) were included in the experimental design to determine an optimal and more suitable sample treatment of BSAcontaining FDC solutions.Using a QbD and Derringer desirability(D) approach,combining BSA loss,dilution factor and variability,we constructed an optimal working space with the edge of failure defined as D<0.9.The design space is modelled and is confirmed to have an ACN range of 83 ± 3% and FA content of 1 ±0.25%. | Lien Taevernier Evelien Wynendaele Matthias D'Hondt Bart De Spiegeleer | 2015 | Journal of Pharmaceutical Analysis2015，5，1： | 2 |
| 15 | Predominant mucosal expression of 5-HT_(4(+h)) receptor splice variants in pig stomach and colon显示文摘AIM: To investigate cellular 5-HT4(-h/+h) receptor distribution, particularly in the epithelial layer, by laser mi-crodissection and polymerase chain reaction (PCR) in porcine gastrointestinal (GI) tissues. METHODS: A stepwise approach was used to evaluate RNA quality and to study cell-specific 5-HT4 receptor mRNA expression in the porcine gastric fundus and colon descendens. After freezing, staining and laser microdissection and pressure catapulting (LMPC), RNA quality was evaluated by the Experion automated electrophoresis system. 5-HT4 receptor and glyceral-dehyde-3-phosphate dehydrogenase (GAPDH) expressions were examined by endpoint reverse transcription (RT)-PCR in mucosal and muscle-myenteric plexus (MMP) tissue fractions, in mucosal and MMP parts of hematoxylin and eosin (HE) stained tissue sections andin microdissected patches of the epithelial and circular smooth muscle cell layer in these sections. Pig gastric fundus tissue sections were also stained immunohisto-chemically (IHC) for enterochromaffin cells (EC cells; MAB352); these cells were isolated by LMPC and examined by endpoint RT-PCR. RESULTS: After HE staining, the epithelial and circular smooth muscle cell layer of pig colon descendens and the epithelial cell layer of gastric fundus were identified morphologically and isolated by LMPC. EC cells of pig gastric fundus were successfully stained by IHC and isolated by LMPC. Freezing, HE and IHC staining, and LMPC had no influence on RNA quality. 5-HT4 recep-tor and GAPDH mRNA expressions were detected in mucosa and MMP tissue fractions, and in mucosal and MMP parts of HE stained tissue sections of pig colon descendens and gastric fundus. In the mucosa tissue fractions of both GI regions, the expression of h-exon containing receptor [5-HT4(+h) receptor] mRNA was significantly higher (P<0.01) compared to 5-HT4(-h) re-ceptor expression, and a similar trend was obtained in the mucosal part of HE stained tissue sections. Large microdissected patches of the epithelial and circular smooth muscle cell layer of pig colon descendens and of the epithelial cell layer of pig gastric fundus, also showed 5-HT4 receptor and GAPDH mRNA expression. No 5-HT4 receptor mRNA expression was detected in gastric LMPC-isolated EC cells from IHC stained tissues, which cells were positive for GAPDH. CONCLUSION: Porcine GI mucosa predominantly expresses 5-HT4(+h) receptor splice variants, suggesting their contribution to the 5-HT4 receptor-mediated mu-cosal effects of 5-HT. | Evelien KV Priem Joris H De Maeyer Mado Vandewoestyne Dieter Deforce Romain A Lefebvre | 2013 | World Journal of Gastroenterology2013，19，24： | 2 |
| 16 | Daily changes in uptake, reduction and storage of nitrate in spinach grown at low light intensity显示文摘 | Eveliene S Pieter R Johan S | 1986 | Plant Physiology1986，66，： | 1 |
| 17 | Dis- crepancy between the in vitro and in vivo effects of murine mesen- chymal stem cells on T-cell proliferation and collagen-induced ar- thritis 显示文摘 | Evelien Schurgers Hilde Kelchtermans Tania Mitera | 2010 | Arthritis Research & Therapy2010，12，： | 1 |
| 18 | Social network analysis: a powerful strat-egy, also for the information sciences 显示文摘 | Evelien Otte Ronald Rousseau | 2002 | Journal of Information Science2002，28，6： | 1 |
| 19 | Randomized clinical trial of an intensive nursing-based pain education program for cancer outpatients suffering from pain显示文摘 | Evelien H. Peet Marieke H. J. Beuken-van Everdingen Jacob Patijn Harry C. Schouten Maarten Kleef Annemie M. Courtens | 2009 | Supportive Care in Cancer2009，，8： | 1 |
| 20 | Social network analysis:A powerful strategy, 'also for the information sciences 显示文摘 | Evelien O Ronald R | 2002 | Journal of Information Sci- ence2002，28，6： | 1 |
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