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| 1 | Transjugular intrahepatic portosystemic shunt for the management of acute variceal hemorrhage显示文摘Acute variceal hemorrhage,a life-threatening condition that requires a multidisciplinary approach for effective therapy,is defined as visible bleeding from an esophageal or gastric varix at the time of endoscopy,the presence of large esophageal varices with recent stigmata of bleeding,or fresh blood visible in the stomach with no other source of bleeding identified.Transfusion of blood products,pharmacological treatments and early endoscopic therapy are often effective;however,if primary hemostasis cannot be obtained or if uncontrollable early rebleeding occurs,transjugular intrahepatic portosystemic shunt(TIPS)is recommended as rescue treatment.The TIPS represents a major advance in the treatment of complications of portal hypertension.Acute variceal hemorrhage that is poorly controlled with endoscopic therapy is generally well controlled with TIPS,which has a 90%to 100%success rate.However,TIPS is associated with a mortality of 30%to 50%in such a setting.Emergency TIPS should be considered early in patients with refractory variceal bleeding once medical treatment and endoscopic sclerotherapy failure,before the clinical condition worsens.Furthermore,admission to specialized centers is mandatory in such a setting and regional protocols are essential to be organized effectively.This review article discusses initial management and then focuses on the specific role of TIPS as a primary therapy to control acute variceal hemorrhage,particularly as a rescue therapy following failure of endoscopic approaches. | Romaric Loffroy Louis Estivalet Violaine Cherblanc Sylvain Favelier Pierre Pottecher Samia Hamza Anne Minello Patrick Hillon Pierre Thouant Pierre-Henri Lefevre Denis Krausé Jean-Pierre Cercueil | 2013 | World Journal of Gastroenterology2013，19，37： | 25 |
| 2 | Endovascular management of visceral artery aneurysms: When to watch, when to intervene?显示文摘Visceral artery aneurysms(VAA) include splanchnic and renal artery aneurysms. They represent a rare clinical entity, although their detection is rising due to an increased use of cross-sectional imaging. Rupture is the most devastating complication, and is associated with a high morbidity and mortality. In addition, increased percutaneous endovascular interventions have raised the incidence of iatrogenic visceral artery pseudoaneurysms(VAPAs). For this reason, elective repair is preferable in the appropriately chosen patient. Controversy still exists regarding their treatment. Over the past decade, there has been steady increase in the utilization of minimally invasive, non-operative interventions, for vascular aneurysmal disease. All VAAs and VAPAs can technically be fixed by endovascular techniques but that does not mean they should. These catheter-based techniques constitute an excellent approach in the elective setting. However, in the emergent setting it may carry a higher morbidity and mortality. The decision for intervention has to take into account the size and the natural history of the lesion, the risk of rupture, which is high during pregnancy, and the relative risk of surgical or radiological intervention. For splanchnic artery aneurysms, we should recognize that we are not, in reality, well informed about their natural history. For most asymptomatic aneurysms, expectant treatment is acceptable. For large, symptomatic or aneurysms with a high risk of rupture, endovascular treatment has become the firstline therapy. Treatment of VAPAs is always mandatory because of the high risk of rupture. We present our point of view on interventional radiology in the splanchnic arteries, focusing on what has been achieved and the remaining challenges. | Romaric Loffroy Sylvain Favelier Pierre Pottecher Pierre-Yves Genson Louis Estivalet Sophie Gehin Jean-Pierre Cercueil Denis Krausé | 2015 | World Journal of Radiology2015，7，7： | 11 |
| 3 | Novel imaging biomarkers of response to transcatheter arterial chemoembolization in hepatocellular carcinoma patients显示文摘Hepatocellular carcinoma(HCC)is the third most common cause of cancer death worldwide(1).Most patients present with intermediate or advanced disease that is not amenable to curative treatment,and the median survival in this group is 6-8 months(2).Several studies and welldesigned randomized trials have shown a positive | Sylvain Favelier Louis Estivalet Pierre Pottecher Romaric Loffroy | 2015 | Chinese Journal of Cancer Research2015，27，6： | 2 |
| 4 | D2 Thi92Ala andPPAR-'y2 Prol2Ala polymorphisms interact in the modulation ofinsulin resistance in type 2 diabetic patients 显示文摘 | Estivalet AA Leiria LB Dora JM | 2011 | Obesity2011，19，4： | 1 |
| 5 | Guide des procédures de radiothérapie externe 2007显示文摘 | C. Ortholan S. Estivalet I. Barillot A. Costa J.-P. Gérard | 2007 | Cancer / Radiothérapie2007，，6： | 1 |
| 6 | D2 Th192ala and PPAR Gamma2 Prol2Ala polymorphisms interact in the modulation of in- sulin resistance in type 2 diabetic patients 显示文摘 | Estivalet AA Leiria LB Dora JM | 2011 | Obesity ( Silver Spring)2011，19，4： | 1 |
| 7 | Towards sustainable development strategies: A complex view following the contribution of Edgar Morin 显示文摘 | Luciano Barin Cruz Eugenio Avila Pedrozo Vania de Fatima Barros Estivalete | 2006 | Management Decision2006，44，7： | 1 |
| 8 | D2 Thr92Ala and PPARγ2Pro12Ala polymorphisms interact in the modulation of insulin resistance in type 2 diabetic patients显示文摘 | Estivalet AA Leiria LB Dora JM | 2011 | Obesity2011，19，4： | 1 |
| 9 | Interventional radiology therapies for liver cancer显示文摘Hepatocellular carcinoma(HCC)is the fifth most frequently found primary malignant tumor in the world.Hepatic surgery and liver transplantation are considered optimal for the curative treatment of HCC.However,only 15-20%of HCCs may be surgically treated.Most of the surgically-non-eligible patients have to receive locoregional image-guided interventional treatments including intra-arterial and percutaneous ablative therapies.The goal of this paper is to review these interventional oncology approaches.Ablative therapeutic approaches include chemical therapies(such as ethanol or acetic acid injection),and thermal therapies(such as radiofrequency ablation,laser-induced thermotherapy,microwave ablation,cryoablation,and high-intensity focused ultrasound ablation).Catheter-based therapies include embolotherapy/chemotherapy-based treatments(such as transcatheter arterial chemoembolization,bland embolization,transcatheter arterial chemoinfusion,and chemoembolization with drug-eluting beads),and radiotherapy-based treatments(such as radioembolization with yttrium-90 and injection of iodine-131-labeled lipiodol).As a result of the technical development of locoregional approaches for HCC during the recent decades,the range of combined interventional therapies has been continuously extended.In this article,an evidence-based approach will be used to review the current role of interventional radiology therapies in the management of unresectable HCC. | Romaric Loffroy Louis Estivalet Sylvain Favelier Pierre Pottecher Pierre-Yves Genson Jean-Pierre Cercueil Denis Krause | 2016 | Hepatoma Research2016，2，1： | 0 |
| 10 | Transcatheter embolization as the new reference standard for endoscopically unmanageable upper gastrointestinal bleeding显示文摘Acute nonvariceal upper gastrointestinal bleeding(UGIB) is a major medical emergency problem associated with significant morbidity and mortality.Endoscopy is considered the first method of choice to detect and treat UGIB.Endoscopic therapy usually achieves primary hemostasis,but 10%-30% of these patients have repeat bleeding.In patients in whom hemostasis is not achieved with endoscopic techniques,treatment with transcatheter angiographic embolization(TAE) or surgery is needed.Surgical intervention is usually an expeditious and gratifying endeavor,but it can be associated with high operative mortality rates.A large number of studies support the use of TAE as salvage therapy as an alternative to surgery.However,few studies have compared the results of TAE with that of emergency surgery in terms of efficiency,the frequency of repeat bleeding,and complications.Recently,Ang et al retrospectively compared the outcome of TAE and surgery as salvage therapy of UGIB after failed endoscopic treatment.There were no significant differences in 30 d mortality,complication rates and length of stay although higher rebleeding rates were observed after TAE compared with surgery.In this commentary,we discuss the advantages and drawbacks of these two therapeutic strategies for UGIB.We also attempt to define the exact role of TAE for acute nonvariceal UGIB. | Romaric Loffroy Louis Estivalet Violaine Cherblanc Damien Sottier Boris Guiu Jean-Pierre Cercueil Denis Krausé | 2012 | World Journal of Gastrointestinal Surgery2012，4，10： | 0 |
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