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	题名	作者	年代	出处	被引量
1	Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters.	V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun	2003	World Journal of Gastroenterology2003，9，10：	5
2	Guidelines on the diagnosis,investigation and management chronic lymphocytic leukemia显示文摘	OSCIER D DEARDEN C EREN E	2012	Br J Haematol2012，159，：	1
3	Relation of neuroendocrine cells to transforming growth factor-alpha and epidermal growth factor receptor expression in gastric adenocarcinomas : prognostic implications 显示文摘	Celikel C Eren F Gulluoglu B	2007	Pathol Oncol Res2007，13，3：	1
4	Neuroendocrine differentiation in gastric adenocarcinomas;correlation with tumor stage and expres- sion of VEGF and p53 显示文摘	Eren F Celikel C Gulltiolu B	2004	Pathol Oncol Res2004，10，1：	1
5	Secretory meningiomas:Report of clinical,immunohistochemical findings in 12 cases and review of literature显示文摘	Nagihan C Eren D Nezih O		0，，01：	1
6	Calmodulin kinase Ⅱ inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein显示文摘	Khoo M S Grueter C E Eren M		0，，02：	1
7	Treatment of intertro-chanteric fractures of the femur with Ender nails in patients overthe age of 65 years显示文摘	Eren OT Kücükkaya M Tezer M	2003	Acta Orthop Traumatol Turc2003，37，2：	1
8	Evaluation of macular changes after uncomplicated phacoemul- sification surgery by optical coherence tomography显示文摘	Perente I Utine CA Ozturker C Cakir M Kaya V Eren H	2007	Cur Eye Res2007，32，3：	1
9	Utility of the omentum in sacral reconstruction following total sacrectomy due to recurrent and irradiated giant cell tumour of the spine显示文摘	Unal C Eren GG Isil E	2012	Indian J Plast Surg2012，45，1：	1
10	Mandibular reconstruction after hemimandibulectomy 显示文摘	Karagoz H Eren F Sever C	2012	J Craniofac Surg2012，23，5：	1
11	Mandibular Reconstruction After Hemimandibulectomy 显示文摘	Karagoz H Eren F Sever C	2012	J Craniofac Surg2012，23，5：	1
12	Neuroendocrine differentiation in gastric adenocarcinomas;correlation with tumor stage and expression of VEGF and p53显示文摘	Eren F Celikel C Gulluoglu B	2004	Pathol Oncol Res2004，10，1：	1
13	Evaluation of macular changes after uncom- plicated phacoemulsification surgery by optical coherence tomography 显示文摘	PERENTEi UTINE cA OZTURKER C CAKIR M KAYA V EREN H	2007	Curt Eye Res2007，32，3：	1
14	Removal of titanium impurities from feldspar ores by new flotation collectors 显示文摘	Celik M S C Eren R H	1998	Minerals Engineering1998，11，12：	1
15	Evaluation of aortic elastic properties in patients with exaggerated systolic blood pressure response to exercise testing 显示文摘	Kilicaslan B Eren NK Nazli C	2015	Chn Exp Hypertens2015，37，2：	1
16	Second-trimester genetic amniocentersis: 5-year experience 显示文摘	Turhan N O Eren U Seckin N C	2005	Arch Gynecol Obstet2005，，271：	1
17	Experience with repetitive use of pimecrolimus:exploring the effective and safe use in the treatment of replasing seborrheic dermatitis 显示文摘	Tatlican S Eren C Oktay B	2009	J Dermatology Treat2009，21，2：	1
18	The results of primary repair and early passive rehabilitation in zone Ⅱ flexor tendon injuries in children显示文摘	Kayali C Eren A Agus H	2003	Acts Orthop Traumatol Turc2003，37，3：	1
19	Removal of titanium impurities from feldspar ores by new flotation collectors显示文摘	Celik M S C Eren R H	1998	Minerals Engineering1998，11，12：	1
20	Repair of pretibial atonic wound with long cross-leg flap显示文摘	Melikoglu C Eren F Kok D	2013	Int J Low Extrem Wounds2013，12，：	1

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