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| 1 | Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes显示文摘Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings.Genetically-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution.We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo.We describe the design,fabrication,and assembly of low-noise,multisite/multicolor optoelectrodes.Each shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design requirements.To better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μW.We implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW illumination.We highlight the potential use of this technology for functional dissection of neural circuits. | Komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon | 2018 | Microsystems & Nanoengineering2018，4，1： | 8 |
| 2 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 3 | Cydophosphamide,doxorubicin,and vincristine in etoposide and cisplatin-resistant small cell lung cancer显示文摘 | Shepherd F H Erans W K MacCormick R | 1987 | Cancer Treat Rep1987，71，10： | 1 |
| 4 | Neuropsychiatric dis- orders following vascular brain injury 显示文摘 | Eran Chemerinski MD Steven R Levine MD | 2006 | Mt Sinai J Med2006，73，： | 1 |
| 5 | Electroantenno- gram responses of Hyles lineate (Sphingidae: Lepidoptera) to volatiles from Clarkia breweri (Onagraceae) and other moth-pollinated 显示文摘 | ROBERT A R DOUGLAS M L ERAN P | 1996 | Journal o{ Chemical Ecology1996，22，10： | 1 |
| 6 | Flash-boiling atomi-zation显示文摘 | Eran S Tali B-K Alexander R | 2008 | Progress in Energy and Combustion Sci-ence2008，34，： | 1 |
| 7 | Helicobacter pylori in Hispanics:comparison with blacks and whites of similar age and socioeconomic class显示文摘 | Malaty HM Erans DG Eans DJ J r et at | | Gastroenterology0，105，5： | 1 |
| 8 | Osteogenic growth peptide modulates fracture callus structural and mechanical properties显示文摘 | Yankel C Ralph M Eran R | 2004 | Bone2004，35，： | 1 |
| 9 | Introducting coloured stainless steel显示文摘 | BLOWER R ERANS E T | 1974 | Sheet Metal Ind1974，51，5： | 1 |
| 10 | Hysteroscopy combined with hysterosalpingo-contrast sonography(HyCoSy):a new modality for comprehensive evaluation of the female pelvic organs显示文摘 | Eran H Raoul David R | | 0，，： | 1 |
| 11 | Hysteroscopy combined with hys-terosalpingo contrast sonography (HyCoSy):a new modality forcomprehensive evaluation of the female pelvic organs显示文摘 | Eran H Raoul O David R | 2006 | Gyneco-logical Endocrinology2006，22，4： | 1 |
| 12 | Pressure-induced Metallization of ZnSe显示文摘 | Galit I Hearne G R Eran S | 1995 | Phys Rev B1995，51，5： | 1 |
| 13 | Cydophosphamide,doxorubicin,and vincristine in etoposide and cisplatin-resistant small cell lung cancer显示文摘 | Shepherd FH Erans WK MacCormick R | 1987 | Cencer Treat Rep1987，71，10： | 1 |
| 14 | Edirisinghe decision making for predictivemaintenance in asset information management显示文摘 | Faiz R B Eran A | 2009 | Interdiscipli-nary Journal of Information Knowledge and Manage-ment2009，，4： | 1 |
| 15 | Urban-rural boundary conflicts:The reshaping of Israel's rural map显示文摘 | ERAN R SHOLMO H | 1994 | Journal of Rural Studies1994，，10： | 1 |
| 16 | Hysteroscopy combined with hyste- rosalpingo-contrast sonograpby (HyCoSy) : a new modality for com- prehensive evaluation of the female pelvic organs 显示文摘 | Eran H Raoul David R | 2006 | Gynecological Endocrinology2006，22，4： | 1 |
| 17 | Improved recovery in activities of daily living associated with remission of poststroke depression 显示文摘 | ERAN C ROBERT R JAMES K | 2001 | Stroke2001，32，： | 1 |
| 18 | Policies to control urban sprawl:planning regulations or changes in the 'rules of the game'显示文摘 | ERAN R | 1998 | Urban Studies1998，35，2： | 1 |
| 19 | Genetics and biochemistry of secondary metabolites in plants: an evolutionary perspective显示文摘 | Eran Pichersky David R Gang | 2000 | Trends in Plant Science2000，，10： | 1 |
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