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62篇 您的检索式：作者名="Engelman R"

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	题名	作者	年代	出处	被引量
1	Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation.	Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon	2012	World Journal of Gastrointestinal Oncology2012，4，5：	5
2	Human population in the biodiversity hotspots显示文摘	Cincotta RP Wisnewski J Engelman R 2000	2000	Nature2000，404，：	1
3	The evolution of diabetic response to ischemia/ reperfusion and preconditioning in isolated working rat heart显示文摘	TOSAKI A ENGELMEN D T ENGELMAN R M	1996	Cardiovasc Res1996，31，：	1
4	Fast-track recovery of the coronary bypass patient 显示文摘	Engelman R M Rousou J A Flack J E 3rd	1994	Ann Thorac Surg1994，58，6：	1
5	Constitutive nitric oxide release is impaired after ischemia and reperfusion 显示文摘	Engelman DT Watanabe M Engelman R M	1995	Thorac Cardiovasc Surg1995，26，：	1
6	Tricuspid annuloplasty,Fiveand one-half years experience with 78 patients显示文摘	Boyd A D Engelman R M Isom O W	1974	Thorac Cardiovasc Surg1974，68，：	1
7	Best Prac- tice in Understanding and Managing Lost Circulation Chal- lenges 显示文摘	Wang Hong (Max) Sweatman R Engelman B	2005	SPE958952005，，：	1
8	Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning 显示文摘	UCHIYAMA T ENGELMAN R M MAULIK N	2004	Circulation2004，109，：	1
9	Ischemic preconditioning reduces apoptosis by upregulating anti-death gene Bcl-2显示文摘	Maulik N Engelman R M Rousou J A	1999	Circulation1999，100，19：	1
10	Constitutive nitric oxide release is impaired after is-chemia and reperfusion显示文摘	Engelman D T Watanabe M Engelman R M	1995	Thorac cardiovasc Surg1995，110，：	1
11	Fasttrack recovery of the coronary bypass patient显示文摘	Engelman R M Rousou J A Flack J E 3rd	1994	Ann Thorac Surg1994，58，6：	1
12	Angiotensin precon ditioning of the heart: evidence for redox signaling显示文摘	Das S Engelman R M Maulik N Das D K	2006	Cell Biochem Biophys2006，44，：	1
13	Molecular adaptation of cellular defenses following preconditioning of the heart by repeated ischemia显示文摘	Das DK Engelman R M Kimura J M	1993	Cardiovasc Res1993，27，：	1
14	Constitutively active mitogen-activated protein kinase kinase 6 (MKK6) or salicylate induces spontaneous 3T3-L1 adipogenesis显示文摘	Engelman J A Berg A H Lewis R Y	1999	J Biol Chem1999，274，35：	1
15	Clinical activity of crizotinib in advanced non-small cell lung cancer(NSCLC)harboring ROS1 gene rearrangement显示文摘	Shaw A T Camidge D R Engelman J A	2012	J Clin Oncol2012，30，：	1
16	The PI3K pathway as drug target in human cancer显示文摘	Courtney K D Corcoran R B Engelman J A	2010	J Clin Oncol2010，28，6：	1
17	P21Cip1 Nullizygosity increases tumor metastasis in irradiated mice 显示文摘	Jackson R J Engelman RW Coppola D	2003	Cancer Res2003，15，12：	1
18	Improvement of ischemia-reperfusion-induced myocardial dysfunction by modulating calcium overload using a novel,specific calmodulin antagonist,CGS9343B显示文摘	Das D K Engelman R M Prasad M R	1989	Biochem Pharmaeol1989，38，：	1
19	Hypoxic preconditioning preserves antioxidant reserve in the working rat heart显示文摘	Watanbe M Engelman R M	1995	Cardiovasc Res1995，29，：	1
20	Navier-stokes simulations of flow past three dimensional submarine models 显示文摘	Givier R C Garting C K Engelman M S	1991	The Methods in Applied Mechanics and Engineering1991，，：	1

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