|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sedation in gastrointestinal endoscopy: Current issues显示文摘Diagnostic and therapeutic endoscopy can successfully be performed by applying moderate(conscious) sedation.Moderate sedation,using midazolam and an opioid,is the standard method of sedation,although propofol is increasingly being used in many countries because the satisfaction of endoscopists with propofol sedation is greater compared with their satisfaction with conventional sedation.Moreover,the use of propofol is currently preferred for the endoscopic sedation of patients with advanced liver disease due to its short biologic half-life and,consequently,its low risk of inducing hepatic encephalopathy.In the future,propofol could become the preferred sedation agent,especially for routine colonoscopy.Midazolam is the benzodiazepine of choice because of its shorter duration of action and better pharmacokinetic profile compared with diazepam.Among opioids,pethidine and fentanyl are the most popular.A number of other substances have been tested in several clinical trials with promising results.Among them,newer opioids,such as remifentanil,enable a faster recovery.The controversy regarding the administration of sedation by an endoscopist or an experienced nurse,as well as the optimal staffing of en-doscopy units,continues to be a matter of discussion.Safe sedation in special clinical circumstances,such as in the cases of obese,pregnant,and elderly individuals,as well as patients with chronic lung,renal or liver disease,requires modification of the dose of the drugs used for sedation.In the great majority of patients,sedation under the supervision of a properly trained endoscopist remains the standard practice worldwide.In this review,an overview of the current knowledge concerning sedation during digestive endoscopy will be provided based on the data in the current literature. | John K Triantafillidis Emmanuel Merikas Dimitrios Nikolakis Apostolos E Papalois | 2013 | World Journal of Gastroenterology2013，19，4： | 35 |
| 2 | Effect of percutaneous endoscopic gastrostomy on gastroesophageal reflux in mechanically-ventilated patients显示文摘瞄准:在机械地通气的病人在胃的食道的倒流(GER ) 上调查经皮的内视镜的胃造口术(木钉) 的效果。方法:在未来的、使随机化的、控制研究有周期性或坚持的联系通风机的肺病(VAP ) 和 GER >
的 36 个病人 6% 被划分成木钉组(n = 16 ) 或非木钉组(n = 20 ) 。11 通气了没有倒流的病人(GER <
3%) 用作控制组。食道的 pH-metry 被执行由在基线“渡过”方法,在木钉以后的 2 和 7 d。病人们严格地被跟随在上面为胃的滋养的残余的半侧卧的位置和控制。结果:median (范围)的重要减少倒流从 7.8 在木钉组被观察( 6.2 - 15.6 )在到 2.7 的基线( 0 - 10.4 )在 d 上 7 post-gastrostomy ( P <
0.01 ),当倒流从 9 增加了时( 6.2 - 22 )到 10.8 ( 6.3 - 36.6 )( P <
0.01 )在非木钉组。在 GER (%) 和 nasogastric 试管的停留之间的重要关联被检测(r = 0.56, P <
0.01 ) 。结论:胃造口术什么时候与滋养的胃的残余的半侧卧的位置和缺席结合了,在通气病人减少胃的食道的倒流。 | Emmanuel E Douzinas Andreas Tsapalos Antonios Dimitrakopoulos Evanthia Diamanti-Kandarakis Alexandros D Rapidis Charis Roussos | 2006 | World Journal of Gastroenterology2006，12，1： | 15 |
| 3 | Acute renal dysfunction in liver diseases显示文摘Renal dysfunction is common in liver diseases,either as part of multiorgan involvement in acute illness or secondary to advanced liver disease.The presence of renal impairment in both groups is a poor prognostic indicator.Renal failure is often multifactorial and can present as pre-renal or intrinsic renal dysfunction.Obstructive or post renal dysfunction only rarely complicates liver disease.Hepatorenal syndrome(HRS)is a unique form of renal failure associated with advanced liver disease or cirrhosis,and is characterized by functional renal impairment without significant changes in renal histology.Irrespective of the type of renal failure,renal hypoperfusion is the central pathogenetic mechanism,due either to reduced perfusion pressure or increased renal vascular resistance.Volume expansion,avoidance of precipitating factors and treatment of underlying liver disease constitute the mainstay of therapy to prevent and reverse renal impairment.Splanchnic vasoconstrictor agents,such as terlipressin,along with volume expansion,and early placement of transjugular intrahepatic portosystemic shunt(TIPS)may be effective in improving renal function in HRS.Continuous renal replacement therapy(CRRT)and molecular absorbent recirculating system(MARS)in selected patients may be life saving while awaiting liver transplantation. | Alex P Betrosian Banwari Agarwal Emmanuel E Douzinas | 2007 | World Journal of Gastroenterology2007，13，42： | 14 |
| 4 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 5 | Favorable response to subcutaneous administration of infliximab in rats with experimental colitis显示文摘AIM: To investigate the influence of infliximab (Remicade)on experimental colitis produced by 2,4,6,trinitrobenzene sulfonic acid (TNBS) in rats.METHODS: Thirty-six Wistar rats were allocated into four groups (three groups of six animals each and a fourth of 12 animals). Six more healthy animals served as normal controls (Group 5). Group 1:colitis was induced by intracolonic installation of 25 mg of TNBS dissolved in 0.25 mL of 50% ethanol and infliximab was subcutaneously administered at a dose of 5 mg/kg BW; Group 2: colitis was induced and infliximab was subcutaneously administered at a dose of 10 mg/kg BW; Group 3: colitis was induced and infliximab was subcutaneously administered at a dose of 15 mg/kg BW; Group 4: colitis was induced without treatment with infliximab. Infliximab was administered on d 2-6. On the 7th d, all animals were killed. The colon was fixed in 10%buffered formalin and examined by light microscopy for the presence and activity of colitis and the extent of tissue damage. Tumor necrosis factor-alpha (TNF-α) and malondialdehyde (MDA) were also measured.RESULTS: Significant differences concerning the presence of reparable lesions and the extent of bowel mucosa without active inflammation in all groups of animals treated with infliximab compared with controls were found. Significant reduction of the tissue levels of TNF-α in all groups of treated animals as compared withthe untreated ones was found (0.47±0.44, 1.09±0.86,0.43±0.31 vs 18.73±10.53 respectively). Significant reduction in the tissue levels of MDA was noticed in group 1 as compared to group 4, as well as between groups 2 and 4.CONCLUSION: Subcutaneous administration of infliximab reduces the inflammatory activity as well as tissue TNF-α and MDA levels in chemical colitis in rats.Infliximab at a dose of 5 mg/kg BW achieves better histological results and produces higher reduction of the levels of TNF-α than at a dose of 10 mg/kg BW.Infliximab at a dose of 5 mg/kg BW produces higher reduction of tissue MDA levels than at a dose of 15 mg/kg BW. | John K Triantafillidis Apostolos E Papalois Aikaterini Parasi Emmanuel Anagnostakis Stavros Burnazos Aristofanis Gikas Emmanuel G Merikas Emmanuel Douzinas Maria Karagianni Helen Sotiriou | 2005 | World Journal of Gastroenterology2005，11，43： | 5 |
| 6 | Lipoma induced jejunojejunal intussusception显示文摘Intussusception in adults is rare. The clinical picture of intussusception in adults is subtle and the diagnosis is,therefore,elusive. The presence of a structural abnor- mality in the great majority of the adult cases mandates high clinical suspicion. Gastrointestinal lipomas are rare benign tumors and intussusception due to a gastrointes- tinal lipoma constitutes an infrequent clinical entity. The present report describes a case of jejunojejunal intus- susception in an adult with a history of severe episodes of hematochezia and colicky upper abdominal pain. The diagnosis was suspected preoperatively but computed tomography scan could not rule out malignancy. Explor- atory laparotomy revealed jejunojejunal intussusception secondary to a lipoma which was successfully treated with segmental intestinal resection. | Andreas Manouras Emmanuel E Lagoudianakis Dimitrios Dardamanis Dimitrios K Tsekouras Haridimos Markogiannakis Michael Genetzakis Nikolaos Pararas Artemisia Papadima Christos Triantafillou Vagelogiannis Katergiannakis | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 7 | Reasons of PEG failure to eliminate gastroesophageal reflux in mechanically ventilated patients显示文摘AIM:To investigate factors predicting failure of percutaneous endoscopic gastrostomy(PEG)to eliminate gastroesophageal reflux(GER). METHODS:Twenty-nine consecutive mechanically ventilated patients were investigated.Patients were evaluated for GER by pH-metry pre-PEG and on the 7th post-PEG day.Endoscopic and histologic evidence of reflux esophagitis was also carried out.A beneficial response to PEG was considered when pH-metry on the 7th post-PEG day showed that GER was below 4%. RESULTS:Seventeen patients responded(RESP group)and 12 did not respond(N-RESP)to PEG.The mean age,sex,weight and APACHEⅡscore were similar in both groups.GER(%)values were similar in both groups at baseline,but were significantly reduced in the RESP group compared with the N-RESP group on the 7th post-PEG day[2.5(0.6-3.8)vs 8.1(7.4-9.2, P<0.001)].Reflux esophagitis and the gastroesophageal flap valve(GEFV)grading differed significantly between the two groups(P=0.031 and P=0.020, respectively).Histology revealed no significant differences between the two groups.CONCLUSION:Endoscopic grading of GEFV and the presence of severe reflux esophagitis are predisposing factors for failure of PEG to reduce GER in mechanically ventilated patients. | Emmanuel E Douzinas Ilias Andrianakis Olga Livaditi Dimitrios Bakos Katerina Flevari Nikos Goutas Dimitrios Vlachodimitropoulos Marios-Konstantinos Tasoulis Alex P Betrosian | 2009 | World Journal of Gastroenterology2009，15，43： | 2 |
| 8 | Association of Helicobacter Pylori Infection and Colon Cancer显示文摘 | Alexandros Strofilas Emmanuel E Lagoudianakis Charalambos Seretis Apostolos Pappas Nikolaos Koronakis Dimitrios Keramidaris Ilias Koukoutsis Ioannis Chrysikos Ioannis Manouras Andreas Manouras | 2012 | Journal of Clinical Medicine Research2012，，3： | 2 |
| 9 | Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study显示文摘 | Sheila A Bingham Nicholas E Day Robert Luben Pietro Ferrari Nadia Slimani Teresa Norat Fran?oise Clavel-Chapelon Emmanuelle Kesse Alexandra Nieters Heiner Boeing Anne Tj?nneland Kim Overvad Carmen Martinez Miren Dorronsoro Carlos A Gonzalez Timothy J Key | 2003 | The Lancet2003，，9368： | 1 |
| 10 | The SurfaceTexturization of Solar Cells: A New Method Using v-grooves with Controllable Sidewall Angles显示文摘 | Pierre V Olivier E Emmanuel M | 1992 | Sol EnergyMater Sol Cells1992，26，12： | 1 |
| 11 | Development of the mechanical properties of an Ultra-HighPerformance Fiber Reinforced Concrete (UttPFRC)显示文摘 | Katrin Habel Marco Viviani Emmanuel Denari e etal | 2006 | Cement and Concrete Research2006，36，： | 1 |
| 12 | Maghemite nanoparticles and maghemite/silica nanocomposite microspheres as magnetic Fenton catalysts for the removal of water pollutants显示文摘 | Nassira Ferroudj Jimmy Nzimoto Anne Davidson Delphine Talbot Emmanuel Briot Vincent Dupuis Agnès Bée Mohamed Salah Medjram Sébastien Abramson | 2013 | Applied Catalysis B: Environmental2013，，： | 1 |
| 13 | Broiler performance, body weight variance, feed and water intake, and carcass quality at different stocking densities显示文摘 | Feddes J J R Emmanuel E J Zuidhof M J | 2002 | Poult Sci2002，81，： | 1 |
| 14 | Adsorption studies of methylene blue and phenol onto vetiver roots activated carbon prepared by chemical activation 显示文摘 | Altenor S Carene B Emmanuel E | 2009 | Journal of Hazardous Materials2009，165，13： | 1 |
| 15 | Pillared graphene: A new 3-D network nanostructure for enhanced hydrogen storage显示文摘 | Georgios K D Emmanuel T George E F | 2008 | Nano Lett2008，8，10： | 1 |
| 16 | Elevated Circulating IL-113 and TNF-Alpha, and Unaltered IL-6 in First-Trimester Pregnancies Complicated by Threatened Abortion With an Adverse Outcome 显示文摘 | Nicolaos V Constantinos P Emmanuel E | 2006 | Mediators Inflamm2006，2006，30： | 1 |
| 17 | Immobilisafion and bioelectrochemistry of proteins on nanoporous TiO2 and ZnO films 显示文摘 | Emmanuel T Anthony E G C Brian O' Regan | 2001 | J Electroanal Chem2001，517，： | 1 |
| 18 | Demonstrayion of pulmonary embolism with dynamic gadolinium-enhanced spiral CT显示文摘 | Emmanuel E Coche Frank D Hammer Pierre P | 2001 | Eur Radio2001，11，3： | 1 |
| 19 | Immobilisation and bioelectrochemistry of proteins on nanoporous TiO2 and ZnO films 显示文摘 | Emmanuel T Anthony E G C | 2001 | J Electroanal Chem2001，517，12： | 1 |
| 20 | CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts显示文摘 | Ginestier Christophe Liu Suling Diebel Mark E Korkaya Hasan Luo Ming Brown Marty Wicinski Julien Cabaud Olivier Charafe-Jauffret Emmanuelle Birnbaum Daniel Guan Jun-Lin Dontu Gabriela Wicha Max S | 2010 | Journal of Clinical Investigation2010，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员