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| 1 | Usefulness of staging systems and prognostic scores for hepatocellular carcinoma treatments显示文摘Therapeutic management of hepatocellular carcinoma(HCC) is quite complex owing to the underlying cirrhosis and portal vein hypertension. Different scores or classification systems based on liver function and tumoral stages have been published in the recent years. If none of them is currently 'universally' recognized, the Barcelona Clinic Liver Cancer(BCLC) staging system has become the reference classification system in Western countries. Based on a robust treatment algorithm associated with stage stratification, it relies on a high level of evidence. However, BCLC stage B and C HCC include a broad spectrum of tumors but are only matched with a single therapeutic option. Some experts have thus suggested to extend the indications for surgery or for transarterial chemoembolization. In clinical practice, many patients are already treated beyond the scope of recommendations. Additional alternative prognostic scores that could be applied to any therapeutic modality have been recently proposed. They could represent complementary tools to the BCLC staging system and improve the stratification of HCC patients enrolled in clinical trials, as illustrated by the NIACE score. Prospective studies are needed to compare these scores and refine their role in the decision making process. | Xavier Adhoute Guillaume Penaranda Jean Luc Raoul Patrice Le Treut Emilie Bollon Jean Hardwigsen Paul Castellani Hervé Perrier Marc Bourlière | 2016 | World Journal of Hepatology2016，8，17： | 7 |
| 2 | A nearly continuous measure of birth weight for gestational age using a United States national reference显示文摘 | Emily O Ken PK Janet RE | 2003 | BMC Pediatr2003，3，： | 1 |
| 3 | An animal model of cigarette smoke-induced in utero growth retardation 显示文摘 | Emily RE Kristin HH Robert MG | 2008 | Toxicology2008，246，： | 1 |
| 4 | An animal model of cigarette smoke- indueed in utero growth retardation 显示文摘 | Emily RE Kristin HH | 2008 | Toxicology2008，246，23： | 1 |
| 5 | Palliative Resection for Advanced Gastric and Junctional Adenocarcinoma: Which Patients will Benefit from Surgery?显示文摘 | Christophe Mariette Emilie Bruyère Mathieu Messager Virginie Pichot-Delahaye Fran?ois Paye Frédéric Dumont Dorothée Brachet Guillaume Piessen | 2013 | Annals of Surgical Oncology2013，，4： | 1 |
| 6 | Downstream evolution of turbiditic channel complexes in the Pab Range outcrops (Maastrichtian,Pakistan)显示文摘 | Emily Albouy Re'my Deschampsa | 2003 | Marine and Petroleum Geology2003，20，3： | 1 |
| 7 | Selective liver X receptor modulators (SLiMs): What use in human health?显示文摘 | Emilie Viennois Kevin Mouzat Julie Dufour Laurent Morel Jean-Marc Lobaccaro Silvère Baron | 2011 | Molecular and Cellular Endocrinology2011，，2： | 1 |
| 8 | Targeting liver X receptors in human health: deadlock or promising trail?显示文摘 | Emilie Viennois Auré lien JC Pommier Ké vin Mouzat Abdelkader Oumeddour Fatim-Zohra El Hajjaji Julie Dufour Fran? oise Caira David H Volle Silvè re Baron Jean-Marc A Lobaccaro | 2011 | Expert Opinion on Therapeutic Targets2011，，2： | 1 |
| 9 | Surgically-induced chronic reflux in rats: a suitable model for studying esophageal carcinogenesis?显示文摘 | Caroline Gronnier Emilie Bruyère Guillaume Piessen Nicolas Briez Jérome Bot David Buob Emmanuelle Leteurtre Isabelle Van Seuningen Christophe Mariette | 2013 | Surgery2013，，： | 1 |
| 10 | Life-threatening disseminated tuberculosis as a complication of treatment by infliximab for Crohn’s disease: report of two cases, including cerebral tuberculomas and miliary tuberculosis显示文摘 | Claire Tissot Sébastien Couraud Lun Meng Philippe Girard Virginie Avrillon Laurence Gérinière Emilie Perrot Pierre-Jean Souquet | 2012 | Journal of Crohn’s and Colitis2012，，9： | 1 |
| 11 | Charcot-Marie-Tooth-1A and sciatic nerve crush rat models:insights from proteomics显示文摘The sensorimotor and histological aspects of peripheral neuropathies were already studied by our team in two rat models:the sciatic nerve crush and the Charcot-Marie-Tooth-1A disease.In this study,we sought to highlight and compare the protein signature of these two pathological situations.Indeed,the identification of protein profiles in diseases can play an important role in the development of pharmacological targets.In fact,Charcot-Marie-Tooth-1A rats develop motor impairments that are more severe in the hind limbs.Therefore,for the first time,protein expression in sciatic nerve of Charcot-Marie-Tooth-1A rats was examined.First,distal sciatic nerves were collected from Charcot-Marie-Tooth-1A and uninjured wild-type rats aged 3 months.After protein extraction,sequential window acquisition of all theoretical fragment ion spectra liquid chromatography and mass spectrometry was employed.445 proteins mapped to Swiss-Prot or trEMBL Uniprot databases were identified and quantified.Of these,153 proteins showed statistically significant differences between Charcot-Marie-Tooth-1A and wild-type groups.The majority of these proteins were overexpressed in Charcot-Marie-Tooth-1A.Hierarchical clustering and functional enrichment using Gene Ontology were used to group these proteins based on their biological effects concerning Charcot-Marie-Tooth-1A pathophysiology.Second,proteomic characterization of wild-type rats subjected to sciatic nerve crush was performed sequential window acquisition of all theoretical fragment ion spectra liquid chromatography and mass spectrometry.One month after injury,distal sciatic nerves were collected and analyzed as described above.Out of 459 identified proteins,92 showed significant differences between sciatic nerve crush and the uninjured wild-type rats used in the first study.The results suggest that young adult Charcot-Marie-Tooth-1A rats(3 months old)develop compensatory mechanisms at the level of redox balance,protein folding,myelination,and axonogenesis.These mechanisms seem insufficient to hurdle the progress of the disease.Notably,response to oxidative stress appears to be a significant feature of Charcot-Marie-Tooth-1A,potentially playing a role in the pathological process.In contrast to the first experiment,the majority of the proteins that differed from wild-type were downregulated in the sciatic nerve crush group.Functional enrichment suggested that neurogenesis,response to axon injury,and oxidative stress were important biological processes.Protein analysis revealed an imperfect repair at this time point after injury and identified several distinguishable proteins.In conclusion,we suggest that peripheral neuropathies,whether of a genetic or traumatic cause,share some common pathological pathways.This study may provide directions for better characterization of these models and/or identifying new specific therapeutic targets. | Zeina Msheik Stephanie Durand Emilie Pinault Martial Caillaud Laetitia Vignaud Fabrice Billet Mohamed El Massry Alexis Desmoulière | 2023 | Neural Regeneration Research2023，18，6： | 0 |
| 12 | Reply to ‘Comment to: Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia’显示文摘We thank Melsen et al.for their interest in our study.Their remarks allow us to clarify key aspects of our work on human bone marrow NK cell biology.1 Our study reports the unsupervised single-cell analysis of NK cells from eight healthy donors and eight acute myeloid leukemia(AML)patients.1 First,we detected an adaptive NK cell subset that correlated with the cytomegalovirus(CMV)positivity status of the donors. | Adeline Crinier Bertrand Escalière Emilie Narni-Mancinelli Eric Vivier | 2021 | Cellular & Molecular Immunology2021，18，5： | 0 |
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