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| 1 | Effect of Helicobacter pylori on gastric epithelial cells显示文摘The gastrointestinal epithelium has cells with features that make them a powerful line of defense in innate mucosal immunity. Features that allow gastrointestinal epithelial cells to contribute in innate defense include cell barrier integrity, cell turnover, autophagy, and innate immune responses. Helicobacter pylori(H. pylori) is a spiral shape gram negative bacterium that selectively colonizes the gastric epithelium of more than half of the world's population. The infection invariably becomes persistent due to highly specialized mechanisms that facilitate H. pylori 's avoidance of this initial line of host defense as well as adaptive immune mechanisms. The host response is thus unsuccessful in clearing the infection and as a result becomes established as a persistent infection promoting chronic inflammation. In some individuals the associated inflammation contributes to ulcerogenesis or neoplasia. H. pylori has an array of different strategies to interact intimately with epithelial cells and manipulate their cellular processes and functions. Among the multiple aspects that H. pylori affects in gastric epithelial cells are their distribution of epithelial junctions, DNA damage, apoptosis, proliferation, stimulation of cytokine production, and cell transformation. Some of these processes are initiated as a result of the activation of signaling mechanisms activated on binding of H. pylori to cell surface receptors or via soluble virulence factors that gain access to the epithelium. The multiple responses by the epithelium to the infection contribute to pathogenesis associated with H. pylori. | Shatha Alzahrani Taslima T Lina Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 15 |
| 2 | Immune evasion strategies used by Helicobacter pylori显示文摘Helicobacter pylori(H. pylori) is perhaps the most ubiquitous and successful human pathogen, since it colonizes the stomach of more than half of humankind. Infection with this bacterium is commonly acquired during childhood. Once infected, people carry the bacteria for decades or even for life, if not treated. Persistent infection with this pathogen causes gastritis, peptic ulcer disease and is also strongly associated with the development of gastric cancer. Despite induction of innate and adaptive immune responses in the infected individual, the host is unable to clear the bacteria. One widely accepted hallmark of H. pylori is that it successfully and stealthily evades host defense mechanisms. Though the gastric mucosa is well protected against infection, H. pylori is able to reside under the mucus, attach to gastric epithelial cells and cause persistent infection by evading immune responses mediated by host. In this review, we discuss how H. pylori avoids innate and acquired immune response elements, uses gastric epithelial cells as mediators to manipulate host T cell responses and uses virulence factors to avoid adaptive immune responses by T cells to establish a persistent infection. We also discuss in this review how the genetic diversity of this pathogen helps for its survival. | Taslima T Lina Shatha Alzahrani Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes | 2014 | World Journal of Gastroenterology2014，20，36： | 7 |
| 3 | Accuracy of Orbscan pachymetry measurements and DHG ultrasound pachymetry in primary laser in situ keratomileusis and LASIK enhancement procedures显示文摘 | Nader G Iskander Ellen Anderson Penno N.Timothy Peters Howard V Gimbel Maria Ferensowicz | 2001 | Journal of Cataract & Refractive Surgery2001，，5： | 2 |
| 4 | Impact of submerged macrophytes including charophytes on phyto-and zooplankton communities allelopathy ver- sus other mechanism显示文摘 | Ellen V D Wouter J B | 2002 | Aqual Bot2002，72，： | 1 |
| 5 | Impact of submerged macrophytes including charophytes on phyto- and zooplankton communities: allelopathy versus other mechanisms 显示文摘 | Ellen V D Wouter J V D B | 2002 | Aquatic Botany2002，72，34： | 1 |
| 6 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 7 | Mutation detection in the ABCC6 gene and genotype-phenotype analysis in a large international case series affected by pseudoxanthoma elasticum显示文摘 | Ellen G Olivier V Sharon F | 2007 | J Med Genet2007，5，6： | 1 |
| 8 | Impact of submerged macrophytes including charophytes on phyto- and zooplankton communities:Allelopathy versus other mechanisms显示文摘 | ELLEN V D WOUTER J B | 2002 | Aquatic Botany2002，72，34： | 1 |
| 9 | Differential regulation of right and left ;entriculax β-adrenergic receptors in newborolambs with experimenntal cyanoticheart disease显示文摘 | Ellen V Shella H | 1990 | J Clin Invest1990，85，1： | 1 |
| 10 | Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains显示文摘 | Johannes V Swinnen Paul P Van Veldhoven Leen Timmermans Ellen De Schrijver Koen Brusselmans Frank Vanderhoydonc Tine Van de Sande Hannelore Heemers Walter Heyns Guido Verhoeven | 2003 | Biochemical and Biophysical Research Communications2003，，4： | 1 |
| 11 | Challenges for the effective molecular imprinting of proteins显示文摘 | Ellen V Joris P S Martin W | 2011 | Biomaterials2011，32，11： | 1 |
| 12 | Long-term psychological work environment and cardiovascular mortality among Swedish men 显示文摘 | Jeffrey V Johnson Walter Stewart Ellen M Hall | 1996 | Am J Public Health1996，86，： | 1 |
| 13 | Rhizoremediation: A beneficial plant-microbe interaction显示文摘 | IRENE Kuiper ELLEN L L GUIDO V B | 2004 | Mol PlantMicrobe Interact2004，17，1： | 1 |
| 14 | Economic benefits of combining clean energy technologies:the case of solar photovoltaics and battery electric vehicles 显示文摘 | ELLEN D S STEVEN V P SEBASTIEN L | 2015 | Inter- national Journal of Energy Research2015，39，8： | 1 |
| 15 | Impact of submerged macro- phytes including charophytes on phyto-and zooplankton communities: allelopathy versus other mechanisms 显示文摘 | Ellen V D and Wouter J B | 2009 | Aquatic Botany2009，72，： | 1 |
| 16 | Cell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cells显示文摘 | Satoko A Ellen V R | 2005 | Nucleic Acids Research2005，33，10： | 1 |
| 17 | Impact of submerged macrophytes including charophytes on phyto-and zooplankton communities:Allelopathy versus other mechanisms显示文摘 | ELLEN V D WOUTER J B | 2002 | Aquatic Botany2002，72，34： | 1 |
| 18 | Structural Snapshots of Human HDAC8 ProvideInsights into the Class I His- tone Deacetylases显示文摘 | John RS Robert JS Bradley AK Clifford M Joseph DH Andy JJ Christine L Andrew A Joseph JB Ellen C Jie T Bi CS Erik V Robert W Ellen ML Douglas RD Gyorgy S Marc N Mark WK Ronald VS Duncan EM and Leslie WT | 2004 | Structure2004，12，： | 1 |
| 19 | Overview of Rho GTPase history 显示文摘 | Ellen V S Channing J D | 2010 | Science and Business Media2010，10，7： | 1 |
| 20 | An emerging role for Ca2+ /calcineurin/NFAT signaling in cancerogenesis显示文摘 | BUCHHOLZ M ELLEN RIEDER V | 2007 | Cell Cycle2007，6，1： | 1 |
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