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| 1 | Preservation of platelet function in patients with cirrhosis and thrombocytopenia undergoing esophageal variceal ligation显示文摘Background:Thrombocytopenia is a possible risk factor for bleeding after band ligation of esophageal varices.However,elevated von Willebrand factor(VWF)in cirrhosis improves platelet function and could decrease this risk.Our objective was to assess platelet function in patients with cirrhosis undergoing esophageal variceal ligation(EVL).Methods:The assessment consisted of platelet count,antigen and activity of VWF and VWF-cleaving protease ADAMTS-13 activity,and a platelet adhesion and aggregation test simulating vascular flow in vivo(Impact-RR)prior to EVL.Results:Totally 111 patients were divided into three groups according to platelet count:(1)<50×109/L(n=38,34.2%);(2)50×109/L to 100×109/L(n=47,42.3%);and(3)>100×109/L(n=26,23.4%).No statistically significant difference was found in the aggregate size of platelets[group 1:41.0(31.8–67.3)μm 2;group 2:47.0(33.8–71.3)μm 2;and group 3:47.0(34.0–66.0)μm 2;P=0.60]and no significant correlation was found between aggregate size and platelet count(Spearman r=0.07;P=0.47).Surface coverage was 4.1%(2.8%–6.7%),8.5%(4.0%–10.0%),and 9.0%(7.1%–12.0%)(P<0.001)in groups 1,2 and 3,respectively and correlated with platelet count(Spearman r=0.39;P<0.0001).There was no significant difference between groups in VWF or ADAMTS-13.Post-EVL bleeding occurred in six(5.4%)patients(n=2 in group 1,n=1 in group 2,and n=3 in group 3;P=0.32).Patients with bleeding had higher MELD scores[15.0(11.3–20.3)versus 12.0(10.0–15.0);P=0.025],but no difference was demonstrated for platelet function parameters.Conclusion:Platelet function is preserved even in the presence of thrombocytopenia,including in the patients with post-EVL bleeding. | Evandro de Oliveira Souza Elbio Antonio D’Amico Tania Rubia Flores da Rocha Caroline Marcondes Ferreira Juliana Medeiros Batista Luiz Augusto CarneiroD’Albuquerque Flair Jose Carrilho Alberto Queiroz Farias | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，6： | 3 |
| 2 | Colossal magnetoresistant materials:the key role of phase separation显示文摘 | ELBIO D HOTTA T MOREO A | 2001 | Physics Reports2001，344，： | 1 |
| 3 | Global versus local ferromagnetism in a model for diluted magnetic semiconductors studied with Monte Carlo techniques显示文摘 | Matthias M Gonzalo A Elbio D | 2002 | Phys Rev B2002，65，24： | 1 |
| 4 | Colossal magnetoresistant materials:the key role of phase separation 显示文摘 | ELBIO D TAKASHI H | 2001 | Physics Reports2001，344，： | 1 |
| 5 | Global versus local ferromagnetism in a model for diluted magnetic semiconductors studied with Monte Carlo techniques 显示文摘 | MATTHIAS M GONZALO A ELBIO D | 2002 | Phys Rev B2002，65，24： | 1 |
| 6 | Colossal magnetoresistant ma- terials: The key role of phaseseparation 显示文摘 | Elbio D Takashi H Adriana M | 2001 | Phys Rep2001，344，： | 1 |
| 7 | Branch retinal vein thrombosis and visual loss probably associated with pegylated interferon therapy of chronic hepatitis C显示文摘有干扰素治疗的眼科的复杂并发症通常温和、可逆,不要求治疗的退却。我们报导把视觉损失可能与干扰素治疗联系了的一个病人的一个案例。长期的丙肝病毒感染(遗传型 1a ) 在一个 33 年的老无征状的人被诊断。他的过去的病历是不显蓍的,以前的平淡的眼科学检查是正常的。Pegylated 干扰素高山哈并且 ribavirin 被开始。三个星期以后,他报导了视觉的无痛苦的减小。眼科学检查显示出广泛的视网膜内出血和棉花羊毛点,与劣等的分支 retinal 静脉血栓联系了。抗病毒的治疗立即被中止,但是一年以后,他坚持严重地减少的视敏度。这个案例在 pegylated 干扰素治疗期间说明无法预言、严重的复杂并发症的可能性。 | Luciana Lofego Gonalves Alberto Queiroz Farias Patrícia Lofego Gonalves Elbio Antonio D'Amico Flair José Carrilho | 2006 | World Journal of Gastroenterology2006，12，28： | 0 |
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