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| 1 | The role of the cytokines in the pathogenesis of pseudoexfoliation syndrome显示文摘AIM:To examine the mechanism of the development of pseudoexfoliation (PSX) syndrome via both cytokine formation and endothelial vasorelaxing and growth factors that will provide us new therapeutic insights for the treatment. METHODS:This is a cross sectional study included two groups; Group 1:control patients with nuclear cataract(n =20, aged 51-80 years). Group 2:PSX patients with nuclear cataract (n=18, aged 50-90 years). Patients with other ophthalmic problems and systemic diseases were excluded. Vascular endothelial growth factor (VEGF), interleukin-6 (IL-6) and interleukin-1β (IL-1β) and nitrotyrosine levels were determined through serum samples by Enzyme-linked immunosorbent assay (ELISA) method. Nitrite-nitrate levels were measured with photometric endpoint determination. RESULTS:There were no significant differences between the groups in terms of age, VEGF, IL-1β, nitrite-nitrate and nitrotyrosine. The significant results were the mean IL-6 levels that were higher in PSX group 2 (37.68± 29.52 pg/mL) compared to that in control group 1 (15.32± 10.08 pg/mL) (P <0.001). CONCLUSION:Several interacting and extending biochemical pathways may lead to the promotion of VEGF and IL-6 expressions. IL-6 which is the only altered marker in our study may indirectly cause an increase of vascular permeability and neovascularization. We suggest inflammation as a factor that can be involved in etiopathogenesis of PSX. | Zuhal Yildirim Filiz Yildirim Nil Irem Ugun Aylin Sepici-Dinel | 2013 | International Journal of Ophthalmology(English edition)2013，6，1： | 3 |
| 2 | Antioxidant activity of extracts from roasted wheat germ显示文摘 | Krings U El Saharty Y S Berger R G | 2000 | Food Chemistry2000，71，1： | 1 |
| 3 | Intravenous nesiritide a nat riuretic peptide in the treament of decompensated congestive heart failure显示文摘 | Colucci S El U Horton P | 2000 | New Engl J Med2000，343，4： | 1 |
| 4 | Short-term efiets of coenzyme Q,0 in progressive supranuelear palsy: a randomized, placebo-controlled trial显示文摘 | Stamelou M Reuss A Pilatus U el al | 2008 | Mov Disord2008，23，7： | 1 |
| 5 | Challenges inIPF diagnosis, current m anagem ent and future perspectives显示文摘 | W ells A U C o stab el U Poletti V | 2015 | Sarcoidosis Vase Diffuse Lung D is2015，32，1： | 1 |
| 6 | Amblyopia:is visual loss permant显示文摘 | El Mallah MK Chakravarthy U Hart PM | 2000 | Br J Ophtalmol2000，84，9： | 1 |
| 7 | Posterior dynamicstabilization systems:DYNESYS显示文摘 | Schwarzenbach O Berlemann U Stoll TM el al | 2005 | Orthop Ciin Noah(Am)2005，36，3： | 1 |
| 8 | Hypoglyeemia is more com- mon among type 2 diabeles patients with limited health liter- acy:the diabetes study of North California(DISTANCE)显示文摘 | Sarkar U Karter AJ Liu JY el al | 2010 | Gen Intern Med2010，25，4： | 1 |
| 9 | Short QT syndrome : successful prevention of sudden cardiac death in an adolescent by implantable cardioveter defibrillator treatment for primary prophylaxis 显示文摘 | Schimpf R Bauersfeld U Gaita F el al | 2005 | Heart Rhythm2005，2，： | 1 |
| 10 | Functional vision training after MIOL implantation 显示文摘 | Mester U Fahle M Ott G el al | 2008 | Ophthalmologe2008，105，： | 1 |
| 11 | Amblyopia:is visual loss permanent?显示文摘 | El Mallah MK Chakravarthy U Hart PM | | 0，，： | 1 |
| 12 | Clinical variabiSil) and novel mutations in the NHEJ1 gene in patients with a Nijtnegen breakage syndrome-like phenntype 显示文摘 | Dutrannoy V Demuth l Baumann U el a| | 2010 | Hum Murat2010，31，9： | 1 |
| 13 | Use of polysialic acid in repair of the central nervous system显示文摘 | El Maarouf A Petridis AK Rutishauser U | 2006 | Proc Natl Acad Sci USA2006，103，16： | 1 |
| 14 | Intracranial meningeal hemangiopericytoma:the role of radiotherapy:report of 29 cases and review of the literature显示文摘 | Soyuer S Chang EL Selek U | 2004 | Cancer2004，100，7： | 1 |
| 15 | Transforming growth factor beta 2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development显示文摘 | Picht G Welge-l+uessen U Grehn F eL al | | Graefe'' s Arch Clin Exp Ophthahnol0，239，： | 1 |
| 16 | A study on the electrodeposition of tantalum on NiTi alloy in an ionic liquid and corrosion behaviour of the coated alloy显示文摘 | Zein El Abedin S Welz-Biermann U Endres F | 2005 | Electrochemistry Communications2005，7，9： | 1 |
| 17 | A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells显示文摘 | Gunthert U Hofmann M Rudy W el al | 1991 | Cell1991，65，1： | 1 |
| 18 | Dynamic two-stage mechanism of versatile DNA damage recognition by xeroderma pigrnentosurn group C protein显示文摘 | Clement FC Camenisch U Fei J el al | 2010 | Mutat Res2010，685，12： | 1 |
| 19 | Demasking of epithelial cell adhesion molecule(Ep CAM)on circulating epithelial tumor cells by Tween20 treatment in breast cancer patients显示文摘 | Hekimian K Stein EL Pachmann U | 2012 | Clin Chem Lab Med2012，50，4： | 1 |
| 20 | Hospitalizations associatel with rotavirus diarrhea in the United States, 1993 through 1995: surveillance based on the new ICD9 CM rota- virusspecific diagnostic code显示文摘 | Parashar U D Holman RC Clarke MJ el al | 1998 | J Infect Dis1998，177，： | 1 |
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