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| 1 | Evaluation of diagnostic findings and scoring systems in outcome prediction in acute pancreatitis显示文摘AIM: To determine factors related to disease severity, mortality and morbidity in acute pancreatitis. METHODS: One hundred and ninety-nine consecutive patients were admitted with the diagnosis of acute pancreatitis (AP) in a 5-year period (1998-2002). In a prospective design, demographic data, etiology, mean hospital admission time, clinical, radiological, biochemical findings, treatment modalities, mortality and morbidity were recorded. Endocrine insuffi ciency was investigated with oral glucose tolerance test. The relations between these parameters, scoring systems (Ranson, Imrie and APACHE Ⅱ) and patients' outcome were determined by using invariable tests and the receiver operating characteristics curve. RESULTS: One hundred patients were men and 99 were women; the mean age was 55 years. Biliary pancreatitis was the most common form, followed by idiopathic pancreatitis (53/ and 26/, respectively). Sixty-three patients had severe pancreatitis and 136 had mild disease. Respiratory rate > 20/min, pulse rate > 90/min, increased C-reactive protein (CRP), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) levels, organ necrosis > 30/ on computed tomography (CT) and leukocytosis were associated with severe disease. The rate of glucose intolerance, morbidity and mortality were 24.1/, 24.8/ and 13.6/, respectively. CRP > 142 mg/L, BUN > 22 mg/dL, LDH > 667 U/L, base excess > -5, CT severity index > 3 and APACHE score > 8 were related to morbidity and mortality. CONCLUSION: APACHE Ⅱ score, LDH, base excess and CT severity index have prognostic value and CRP is a reliable marker for predicting both mortality and morbidity. | Ekrem Kaya Adem Dervi■o■lu Cafer Polat | 2007 | World Journal of Gastroenterology2007，13，22： | 64 |
| 2 | Type 2 diabetes mellitus and CA 19-9 levels显示文摘AIM:To prospectively investigate serum CA 19-9 levels in type 2 diabetic patients in comparison with age-and gender-matched control subjects. METHODS:We recorded duration of diabetes and examined fasting glucose levels,HbA1c levels and serum CA 19-9 levels in 76 type 2 diabetic patients and 76 controls.Abdominal CT was performed in order to eliminate abdominal malignancy in the diabetic and control groups. RESULTS:The average CA 19-9 level was 46.0±22.4 U/mL for diabetic patients whereas it was 9.97±7.1 U/mL for the control group(P<0.001).Regression analysis showed a positive correlation between diabetes and CA 19-9 independent from age,gender,glucose level and HbA1c level(t=8.8,P<001).Two of the diabetic patients were excluded from the study because of abdominal malignancy shown by CT at the initial evaluation.For all patients,abdominal CT showed no pancreatic abnormalities. CONCLUSION:CA 19-9 is a tumor-associated antigen, which is elevated in pancreatic,upper gastrointestinal tract,ovarian hepatocellular,and colorectal cancers,as well as in inflammatory conditions of the hepatobiliary system,biliary obstruction and in thyroid diseases. Diabetes has been claimed to be a risk factor for pancreatic cancer,which is increasing its incidence and has one of the lowest survival rates of all cancers.CA 19-9 is used in the diagnosis of pancreatic cancer but is also a marker of pancreatic tissue damage that might be caused by diabetes.We propose that a higher cut- off value of CA 19-9 should be used in diabetics to differentiate benign and malignant pancreatic disease, and subtle elevations of CA 19-9 in diabetics should be considered as the indication of exocrine pancreatic dysfunction. | Oya Uygur-Bayramicli Resat Dabak Ekrem Orbay Can Dolapclo■lu Mehmet Sargin Gamze Kilico■lu Yüksel Güleryüzlü Alpaslan Mayada■li | 2007 | World Journal of Gastroenterology2007，13，40： | 63 |
| 3 | Type 2 diabetes mellitus affects eradication rate of Helicobacter pylori显示文摘AIM: To study the eradication rate of Helicobacter pylori (Hp) in a group of type 2 diabetes and compared it with an age and sex matched non-diabetic group.METHODS: 40 diabetic patients (21 females, 19 males;56±7 years) and 40 non-diabetic dyspeptic patients (20females, 20 males; 54±9 years) were evaluated. Diabetic patients with dyspeptic complaints were referred for upper gastrointestinal endoscopies; 2 corpus and 2 antral gastric biopsy specimens were performed on each patient. Patients with positive Hp results on histopathological examination comprised the study group. Non-diabetic dyspeptic patients seen at the Gastroenterology Outpatient Clinic and with the same biopsy and treatment protocol formed the control group.A triple therapy with amoxycillin (1 g b.i.d), clarithromycin (500 mg b.i.d) and omeprazole (20 mg b.i.d.) was given to both groups for 10 days. Cure was defined as the absence of Hp infection assessed by corpus and antrum biopsies in control upper gastrointestinal endoscopies performed 6weeks after completing the antimicrobial therapy.RESULTS: The eradication rate was 50 % in the diabetic group versus 85 % in the non-diabetic control group (P<0.001).CONCLUSION: Type 2 diabetic patients showed a significantly lower eradication rate than controls which may be due to changes in microvasculature of the stomach and to frequent antibiotic usage because of recurrent bacterial infections with the development of resistant strains. | Mehmet Sarg■n OyaUygur-Bayramili Haluk Sarg■n Ekrem Orbay Dilek Yavuzer Ali Yayla | 2003 | World Journal of Gastroenterology2003，9，5： | 25 |
| 4 | Blunt trauma related chest wall and pulmonary injuries: An overview显示文摘Physical traumas are tragic and multifaceted injuries that suddenly threaten life.Although it is the third most common cause of death in all age groups,one out of four trauma patients die due to thoracic injury or its complications.Blunt injuries constitute the majority of chest trauma.This indicates the im porta nee of chest trauma among all traumas.Blunt chest trauma is usually caused by motor vehicle accident,falling from height,blunt instrument injury and physical assault.As a result of chest trauma,many injuries may occur,such as pulm onary injuries,and these require urge nt in terve ntion.Chest wall and pulmonary injuries range from rib fractures to flail chest,pneumothorax to hemothorax and pulmonary contusion to tracheobronchial injuries.Following these injuries,patients may present with a simple dyspnea or even respiratory arrest.For such patie nt,it is imports nt to understa nd the treatme nt logic and to take a multidisciplinary approach to treat the pulmonary and chest wall injuries.This is because only 10%of thoracic trauma patients require surgical operation and the remaining 90%can be treated with simple methods such as appropriate airway,oxygen support,maneuvers,volume support and tube thoracostomy.Adequate pain control in chest trauma is sometimes the most basic and best treatment.With definite diagnosis,the morbidity and mortality can be significantly reduced by simple treatment methods. | Bekir Nihat Dogrul Ibrahim Kiliccalan Ekrem Samet Asci Selim Can Peker | 2020 | Chinese Journal of Traumatology2020，23，3： | 19 |
| 5 | Effects of disease severity and necrosis on pancreatic dysfunction after acute pancreatitis显示文摘AIM:To evaluate the effects of disease severity and necrosis on organ dysfunctions in acute pancreatitis(AP).METHODS:One hundred and nine patients treated as AP between March 2003 and September 2007 with at least 6 mo follow-up were included.Patients were classified according to severity of the disease,necrosis ratio and localization.Subjective clinical evaluation and fecal pancreatic elastase-Ⅰ(FPE-Ⅰ)were used for exocrine dysfunction evaluation,and oral glucose tolerance test was completed for endocrine dysfunction.The correlation of disease severity,necrosis ratio and localization with exocrine and endocrine dysfunction were investigated.RESULTS:There were 58 male and 51 female patients,and mean age was 56.5±15.7.Of the patients,35.8%had severe AP(SAP)and 27.5%had pancreatic necrosis.Exocrine dysfunction was identified in 13.7%of the patients[17.9%were in SAP,11.4%were in mild AP(MAP)]and 34.7%of all of the patients had endocrine dysfunction(56.4%in SAP and 23.2%in MAP).In patients with SAP and necrotizing AP(NAP),FPE-Ⅰlevels were lower than the others(P<0.05 and0.001 respectively)and in patients having pancreatic head necrosis or near total necrosis,FPE-1 levels were lower than 200μg/g stool.Forty percent of the patients who had undergone necrosectomy developed exocrine dysfunction.Endocrine dysfunction was more significant in patients with SAP and NAP(P<0.001).All of the patients in the necrosectomy group had endocrine dysfunction.CONCLUSION:Patients with SAP,NAP,pancreatic head necrosis and necrosectomy should be followed for pancreatic functions. | Gokhan Garip Emre Sarandl Ekrem Kaya | 2013 | World Journal of Gastroenterology2013，19，44： | 12 |
| 6 | Intraoperative acidosis is a new predictor for postoperative pancreatic fistula after pancreaticoduodenectomy显示文摘BACKGROUND:Early diagnosis of postoperative pancreatic fistula(POPF) is important for proper interventions.The preoperative,intraoperative and early postoperative biochemical markers have predictive value of POPF.The present study was to evaluate several simple biochemical parameters in the prediction of POPF.METHODS:Patients who underwent pancreaticoduodenectomy in our center between 2006 and 2015 were reviewed retrospectively.Preoperative and early postoperative biochemical parameters were evaluated.Additionally,the relationship between POPF and p H and lactate level at the end of surgery were analyzed,and neutrophil-to-lymphocyte ratio(NLR),plateletto-lymphocyte ratio(PLR),and red cell distribution widthto-platelet ratio(RPR) were calculated for postoperative days(PODs) 1 and 3.Diagnosis and grading of POPF were performed according to the standards of the International Study Group on Pancreatic Fistula.The patients were divided into two groups:Group 1 with no fistula or grade-A fistula; group 2 with grade-B or-C fistula.These simple biochemical markers were then compared between the two groups.RESULTS:Serum amylase level was significantly higher at POD3,and p H level was significantly lower at the end of operation in group 2 compared with those in group 1.However,the serum amylase was below the upper limit of normal serum level and therefore,the difference was not significant in clinical practice.Receiver operating charecteristic curve analysis showed that p H level was a reliable predictor of POPF(area under the curve:0.713; 95% CI:0.573-0.853).CONCLUSIONS:A low p H level at the end of pancreaticoduodenectomy was a risk factor of POPF.NLR,PLR,and RPR had no predictive value of POPF after pancreaticoduodenectomy. | Erdem Kinaci Mert Mahsuni Sevinc Abdulkerim Ozakay Savas Bayrak Ekrem Cakar Serkan Sari | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，3： | 7 |
| 7 | Thermal entanglement in the mixed three-spin XXZ Heisenberg model on a triangular cell显示文摘We numerically investigate the thermal entanglements of spins(1/2, 1) and spins(1/2, 1/2) in the three-mixed(1/2, 1,1/2) anisotropic Heisenberg XXZ spin system on a simple triangular cell under an inhomogeneous magnetic field. We show that the external magnetic field induces strong plateau formation in the pairwise thermal entanglement for fixed parameters of the Hamiltonian in the cases of ferromagnetic and antiferromagnetic interactions. We also observe an unexpected critical point at finite temperature in the thermal entanglement of spins(1/2, 1) for the antiferromagnetic case, while the entanglement of spins(1/2, 1) in the ferromagnetic case and the entanglement of spins(1/2, 1/2) in both ferromagnetic and antiferromagnetic cases almost decay exponentially to zero with increasing temperature. The critical point in the entanglement of spins(1/2, 1) in the antiferromagnetic case may be a signature of the quantum phase transition at finite temperature. | Seyit Deniz Han Ekrem Aydiner | 2014 | Chinese Physics B2014，23，5： | 5 |
| 8 | 以天然沥青岩为原料制备高压缩强度的泡沫炭(英文)显示文摘以安纳托利亚东南部的天然沥青岩为原料制备泡沫炭。所制泡沫炭的平均孔径和密度分别为150μm和800 kg/m3。主要研究了压力、温度、泄压时间及在最高温度时的停留时间对泡沫形成的影响,同时还评价了炭化过程对泡沫结构的影响。主要研究了压力、温度、泄压时间及在最高温度时的停留时间对泡沫炭进行了表征,并进行了密度及抗压强度分析。结果表明,1 323 K炭化后,泡沫炭压缩强度由10 MPa增加到18.7 MPa。沥青的灰分含量(41.76%)对泡沫炭的密度和压缩强度起重要作用。 | Deniz Baran Mehmet Ferhat Yardim Hüsnü Atakül Ekrem Ekinci | 2013 | 新型炭材料2013，28，2： | 4 |
| 9 | Extraordinary cause of acute gastric dilatation and hepatic portal venous gas: Chronic use of synthetic cannabinoid显示文摘Addiction to synthetic cannabinoids(SCs) is a growing social and health problem worldwide. Chronic use of SCs may cause adverse effects in the gastrointestinal system. We describe a very rare case of acute gastric dilatation(AGD) and hepatic portal venous gas(HPVG),with findings of acute abdomen resulting from chronic use of a SC, Bonzai. AGD and HPVG were detected by computerized tomography examination. Patchy mucosal ischemia was seen in endoscopic examination. Despite the findings of an acute abdomen, a non-surgical approach with nasogastric decompression, antibiotic therapy, and close radiologic and endoscopic followup was preferred in the presented case. Clinical and radiologic findings decreased dramatically on the first day, and endoscopic findings gradually disappeared over 7 d. In conclusion, this case shows that chronic use of a SC may cause AGD and accompanying HPVG,which can be managed non-surgically despite the findings of acute abdomen. | Mert Mahsuni Sevinc Erdem Kinaci Savas Bayrak Aytul Hande Yardimci Ekrem Cakar Hasan Bektas | 2015 | World Journal of Gastroenterology2015，21，37： | 3 |
| 10 | What is the relationship between frailty and orthostatic hypotension in older adults?显示文摘Background Frailty and orthostatic hypotension (OH),which is common in older adults,is associated with morbidity and mortality.The relationship between them remains unclear.The aim of the study is to determine whether there is a relationship between frailty and OH.Methods A total of 496 patients who were admitted to the geriatric clinic and underwent comprehensive geriatric assessment were retrospectively reviewed.In a cross-sectional and observational study,OH was measured by the Head-up Tilt Table test at 1,3,and 5 min (respectively,OH1,OH3,and OH5) and the frailty was measured by the Fried’s frailty scale.Results The mean age of all patients was 75.4 ± 7.38.The prevalence of females was 69.8%.When the frail people were compared with the pre-frail and the robust ones,the frailty was associated with OH1.There was no relationship between the groups in terms of OH1 when the pre-frail group was compared with the robust group.OH3 were higher in the frail group than in the pre-frail group (P < 0.05) and the OH5 were higher in the frail group than in the pre-frail and robust group (P < 0.05),but OH3 and OH5 were not associated with frailty status when they were adjusted for age (P > 0.05).Slowness and weakness were associated with OH1 (P < 0.05),whereas the other components of the Fried’s test were not.Conclusions Frailty may be a risk factor for OH1.The 1^st min measurements of OH should be routinely evaluated in frail older adults to prevent OH-related poor outcomes. | Suleyman Emre Kocyigit Pinar Soysal Esra Ates Bulut Ali Ekrem Aydin Ozge Dokuzlar Ahmet Turan Isik | 2019 | Journal of Geriatric Cardiology2019，16，3： | 3 |
| 11 | Short-term impacts of biochar and manure application on soil labile carbon fractions,enzyme activity,and microbial community structure显示文摘Biochar is known to ameliorate soil fertility and increase crop yield;however,information regarding its effects on soil chemical and biological properties remains limited.The experiment was conducted to study the short-term impacts of dif-ferent types of biochar on soil C fractions,enzyme activities,and microbial community structure at depositional and eroded landscape positions at different sampling times[before planting,after planting,and after harvesting of soybean(Glycine max L.)].Three biochar materials,produced from C-optimized gasification of corn(maize,Zea mays L.)stover(CS),pon-derosa pine(Pinus ponderosa Lawson and C.Lawson)wood residue(PW),and switchgrass(Panicum virgatum L.)(SG),and dairy manure(DM)and mixture of dairy manure and pinewood biochar(DMP),were applied at a rate of 10 Mg ha^(−1) to depositional and eroded landscape positions.Data showed that the application of DMP and sole application of DM treat-ments significantly increased the labile C fractions at the depositional and eroded landscapes.The addition of DM and DMP increased the activities ofβ-glucosidase and urease enzymes,and those are involved in C and nitrogen cycling at depositional and eroded landscape positions.There were no significant differences between different biochar materials.However,there was an increase in soil microbial community structure in the DM and DMP treatments at both the landscape positions.In conclusion,our study revealed that DMP and sole application of DM influenced the soil labile C pool,enzyme activities,and microbial community structure at both the landscape positions for different sampling times. | Saroop Sandhu Udayakumar Sekaran Ekrem Ozlu Nigel O.Hoilett Sandeep Kumar | 2019 | Biochar2019，1，3： | 2 |
| 12 | Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay- directed fractionation techniques显示文摘 | Ekrem Sezik Mustafa Aslan Erdem Yesilada Shigeru Ito | 2004 | Life Sciences2004，，11： | 2 |
| 13 | Occurrence and removal of metals in urban wastewater treatment plants显示文摘 | GOkhan Ekrem Ostiin | 2009 | Journal of Haza - rdous Materials2009，172，： | 1 |
| 14 | Removal of copper from aqueous solution using red mud显示文摘 | Hayrunnisa Nadaroglu Ekrem Kalkan Nazan Demir | 2010 | Desalination2010，251，： | 1 |
| 15 | Secrecy in Cooperative relay broadcast channels 显示文摘 | EKREM E ULUKUS S | 2011 | IEEE Trans on Information Theory2011，57，1： | 1 |
| 16 | Trends in application of imaging technologies to inspection of fish and fish products显示文摘 | Mathiassen John Reidar Misimi Ekrem Bond Morten | | 0，，06： | 1 |
| 17 | PPAR-γ2 Prol2Ala polymorphism is associated with weight gain in women with gestational diabetes mellitus显示文摘 | Ekrem CT Devrim E Ozlem B | 2006 | Eur J Obstet Gynecol Reprod Biol2006，129，2： | 1 |
| 18 | Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder显示文摘 | Marin Veldic Bashkim Kadriu Ekrem Maloku Roberto C. Agis-Balboa Alessandro Guidotti John M. Davis Erminio Costa | 2007 | Schizophrenia Research2007，，1： | 1 |
| 19 | Secrecy in cooperative relay broadcast channels显示文摘 | Ekrem E Ulukus S | 2011 | IEEE Trans IT2011，57，1： | 1 |
| 20 | On subclass of univalent functions with negative coefficient显示文摘 | Ekrem Kadioglu | 2003 | Applied Mathematics and Computation2003，146，： | 1 |
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