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| 1 | Quadruple therapy with furazolidone for retreatment in patients with peptic ulcer disease显示文摘AIM: To establish the efficacy and safety of a 7-d therapeutic regimen using omeprazole,bismuth subcitrate,furazolidone and amoxicillin in patients with peptic ulcer disease who had been previously treated with other therapeutic regimens without success.METHODS: Open cohort study which included patients with peptic ulcer who had previously been treated unsuccessfully with one or more eradication regimens.The therapeutic regimen consisted of 20 mg omeprazole,240 mg colloidal bismuth subcitrate,1000 mg amoxicillin,and 200 mg furazolidone,taken twice a day for 7 d.Patients were considered as eradicated when samples taken from the gastric antrum and corpus 12 wk after the end of treatment were negative for Helicobacter pylori (H pylori) (rapid urease test and histology).Safety was determined by the presence of adverse effects.RESULTS: Fifty-one patients were enrolled.The eradication rate was 68.8% (31/45).Adverse effects were reported by 31.4% of the patients,and these were usually considered to be slight or moderate in the majority of the cases.Three patients had to withdraw from the treatment due to the presence of severe adverse effects.CONCLUSION: The association of bismuth,furazolidone,amoxicillin and a proton-pump inhibitor is a valuable alternative for patients who failed to respond to other eradication regimens.It is an effective,cheap and safe option for salvage therapy of positive patients. | Guilherme Eduardo Gonalves Felga Fernando Marcuz Silva Ricardo Correa Barbuti Tomás Navarro-Rodriguez Schlioma Zaterka Jaime Natan Eisig | 2008 | World Journal of Gastroenterology2008，14，40： | 9 |
| 2 | Epidemiology of upper gastrointestinal symptoms in Brazil(Epi Gastro):A population-based study according to sex and age group显示文摘AIM:To determine the prevalences of symptoms consistent with gastroesophageal reflux disease(GERD)and dyspepsia in South America.METHODS:A telephone survey was conducted among adult owners of land-based telephones in S?o Paulo,Brazil,using previously validated computer-assisted sampling and survey protocols.The Portugueselanguage survey included(1)sociodemographic characteristics(e.g.,weight,height,smoking)and comorbidities;(2)dietary habits;(3)presence of symptoms consistent with GERD or dyspepsia within the prior 3mo;and(4)use of medications and other therapies to manage symptoms.Data were stratified post-hoc into three homogeneous geographical regions of S?o Paulo according to the Social Exclusion Indices of the districts and postal codes.Survey response data from each respondent were weighted by the numbers of adults and landline telephones in each household.The analyses were weighted to account for sampling design and to be representative of the S?o Paulo population according to city census data.RESULTS:Among 4570 households contacted,an adult from 3050(66.7%)agreed to participate.The nonresponse rate was 33.3%.The mean(SE)respondent age was 42.6(16.0)years.More than half of all respondents were women(53.1%),aged 18 through 49 years(66.7%),married or cohabitating(52.5%),and/or above normal-weight standards(i.e.,35.3%overweight and 16.3%obese).A total of 26.5%of women were perimenopausal.More than 20%of respondents reported highly frequent symptoms consistent with GERD(e.g.,gastric burning sensation=20.8%)or dyspepsia(e.g.,abdominal swelling/distension=20.9%)at least once per month.Prevalences of these symptoms were significantly(approximately 1.5-to 2.0-fold)higher among women than men but did not vary significantly as a function of advancing age.For instance,14.1%of women reported that they experienced stomach burning(symptom of GERD)at least twice per week,compared to 8.4%of men(P=0.012 byχ2 test).A total of 15.7%of women reported that they experienced abdominal swelling(symptom of dyspepsia)at least twice per week,compared to 6.4%of men(P<0.001byχ2 test).Despite frequent manifestations of GERD or dyspepsia,most(≥90%)respondents reported that they neither received prescription medications fromphysicians,nor took behavioral measures(e.g.,dietary modifications),to manage symptoms.CONCLUSION:Symptoms consistent with dyspepsia and GERD are prevalent in Brazil and represent major public-health and clinical challenges. | Maria do Rosário Dias de Oliveira Latorre Aline Medeiros da Silva Décio Chinzon Jaime N Eisig Telma RP Dias-Bastos | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 3 | Two-piece Le Fort Ⅰ osteotomy for cranial base access 显示文摘 | Eisig S Hall C Goodrich JT | 2000 | J Oral Maxillafoc Surg2000，58，： | 1 |
| 4 | A furazolidone-based quadruple therapy for Helicobacter pylori retreatment in patients with peptic ulcer disease显示文摘 | Eisig JN Silva FM Rodriguez TN | 2005 | Clinics2005，60，6： | 1 |
| 5 | A furazolidone- based quadruple therapy for Helicobacter pylori retreatment in patients with peptic ulcer disease 显示文摘 | Eisig JN Silva FM Rodriguez TN | 2005 | Clinics2005，60，： | 1 |
| 6 | Major aphthous-like ulcers in patients with AIDS显示文摘 | Phelan JA Eisig S Freedman PD | | 0，，1： | 1 |
| 7 | Efficacy of a 7-day course of furazolidone,levofloxacin,and lansoprazole after failedHelicobacter pylori eradication显示文摘 | Eisig J N Silva FM Barbuti RC | | 0，，： | 1 |
| 8 | The 2-piece Le Fort I osteotomy for cranial base access:an evaluation of 9 patients显示文摘 | Eisig SB Feghali J Hall C | 2000 | J Oral Maxillofac Surg2000，58，5： | 1 |
| 9 | Factors affecting Helicobacter pylori eradication using a seven-day triple therapy with a proton pump in- hibitor, tinidazole and clarithromycin, in Brazilian patients with pep- tie ulcer 显示文摘 | Silva FM Zaterka S Eisig JN | 2001 | Rev Hosp Clin Fae Med Sao Paulo2001，56，1： | 1 |
| 10 | The 2-piece Le Fort Ⅰ osteotomy for cranial base access:an evaluation of 9 patients显示文摘 | Eisig SB Fegbali J Hall C | 2000 | J Oral Maxillofac Surg2000，58，5： | 1 |
| 11 | Prevalence of heartburn and gastroesophageal reflux disease in the urban brazilian population 显示文摘 | Moraes-Filho JP Chinzon D Eisig JN | 2005 | Arq Gastroenterol2005，42，2： | 1 |
| 12 | Efficacy of a 7-day course of furazolidone,levofloxacin,and lansoprazole after failed Helicobacter pylori eradication显示文摘 | Eisig JN Silva FM Barbuti RC | 2009 | BMC Gastroenterol2009，9，： | 1 |
| 13 | The impaact of Helicobacter pylori resistance on the efficacy of a short cuorse pantopragole based tripletherapy显示文摘 | Eisig J N Andre S B silva F M | 2003 | Arq Gstroenterol2003，40，1： | 1 |
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