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| 1 | Small bowel tumors detected and missed during capsule endoscopy: Single center experience显示文摘AIM:To characterize small bowel(SB)tumors detected by capsule endoscopy(CE),and identify missed tumors.METHODS:The study included 145 consecutive patients in whom 150 CEs were performed.Following CE,the medical records of the study population were reviewed.Results of double-or single-balloon enteroscopy performed after CE and the results of surgery in all patients operated on were retrieved.The patients were contacted through telephone interviews or postal mail.In addition,the national cancer registry and the polish clinical gastrointestinal stromal tumor(GIST)Registry were searched to identify missed neoplasms.RESULTS:Indications for CE included overt and occult obscure gastrointestinal bleeding(n=81,53.7%),anemia(n=19,12.7%),malabsorption(n=18,12%),abnormal CB follow through(n=9,6%),abdominal pain(n=7,5%),celiac disease(n=5,3%),neuroendocrine tumor(n=3,2%),Crohn’s disease(n=2,<2%),Peutz-Jeghers syndrome(n=2,<2%),other polyposes(n=2,<2%),and diarrhea(n=2,<2%).The capsule reached the colon in 115(76.6%)examinations.In 150 investigations,CE identified 15SB tumors(10%),14 of which were operated on or treated endoscopically.Malignancies included metastatic melanoma(n=1),adenocarcinoma(n=2),and GIST(n=3).Benign neoplasms included dysplastic Peutz-Jeghers polyps(n=4).Non-neoplastic masses included venous malformation(n=1),inflammatory tumors(n=2),and a mass of unknown histology(n=1).During the follow-up period,three additional SB tumors were found(2 GISTs and one mesenteric tumor of undefined nature).The National Cancer Registry and Polish Clinical GIST Registry revealed no additional SB neoplasms in the post-examination period(follow-up:range 4.2-102.5 mo,median 39 mo).The sensitivity of CE for tumor detection was 83.3%,and the negative predictive value was 97.6%.The specificity and positive predictive value were both 100%.CONCLUSION:Neoplasms may be missed by CE,especially in the proximal SB.In overt obscure gastrointestinal bleeding,complementary endoscopic and/or radiologic diagnostic tests are indicated. | Edyta S Zagorowicz Anna M Pietrzak Ewa Wronska Jacek Pachlewski Piotr Rutkowski Ewa Kraszewska Jaroslaw Regula | 2013 | World Journal of Gastroenterology2013，19，47： | 10 |
| 2 | Biological therapy in inflammatory bowel diseases:Access in Central and Eastern Europe显示文摘Biological drugs opened up new horizons in the management of inflammatory bowel diseases(IBD).This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European(CEE)countries,namely Bulgaria,the Czech Republic,Estonia,Hungary,Latvia,Lithuania,Poland,Romania and Slovakia.Literature data on the epidemiology and disease burden of IBD in CEE countries was systematically reviewed.Moreover,we provide an estimation on prevalence of IBD as well as biological treatment rates.In all countries with the exception of Romania,lower biological treatment rates were observed in ulcerative colitis(UC)compared to Crohn’s disease despite the higher prevalence of UC.Great heterogeneity(up to 96-fold)was found in access to biologicals across the CEE countries.Poland,Bulgaria,Romania and the Baltic States are lagging behind Hungary,Slovakia and the Czech Republic in their access to biologicals.Variations of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria,Latvia,Lithuania,and Poland,but association with other possible determinants(differences in prevalence and incidence,price of biologicals,total expenditure on health,geographical access,and cost-effectiveness results)was not proven.We assume,nevertheless,that healthdeterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for IBD.In conclusion,access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors,drug prices or total health expenditure.Changes in reimbursement policy could contribute to better access to biologicals in some countries. | Fanni Rencz Márta Péntek Martin Bortlik Edyta Zagorowicz Tibor Hlavaty Andrzej Sliwczyński Mihai M Diculescu Limas Kupcinskas Krisztina B Gecse László Gulácsi Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，6： | 4 |
| 3 | Short-dayand melatonin effects on milking parameters, prolactin profilesand growth-hormone secretion in lactating sheep 显示文摘 | EDYTA M TOMASZ M KATARZYNA R | 2013 | SmallRuminant Research*2013，109，： | 1 |
| 4 | Short-day and me- latonin effects on milking parameters, prolactin profiles and growth-hormone secretion in lactating sheep显示文摘 | Edyta M Tomasz M Katatxyna R | 2013 | Small Rumi- nant Research2013，109，： | 1 |
| 5 | Effect of an aliphatic spacer group on the adsorption mechanism on the colloidal silver surface of L proline phosphonodipeptides显示文摘 | EDYTA P PAWEL K LEONARD M P | 2008 | J Raman Spectroscopy2008，39，12： | 1 |
| 6 | Impact of osmotic stress on physiological and biochemical characteristics in drought susceptible and drought resistant wheat genotypes显示文摘 | Izabela M Ilona C M Edyta S et a l | 2013 | Acta Physiologiae Plantarum2013，35，2： | 1 |
| 7 | Prospects of androgenetic induction in Lupinus spp显示文摘 | Edyta S Ilona Czyczylo-Mysza Izabela M | 2008 | Plant Cell Tiss Organ Cult2008，94，： | 1 |
| 8 | Antidepressant-like effect of tetrahydroisoquinoline amines in the animal model of depressive disorder induced by repeated administration of a low dose of reserpine:behavioral and neurochemical studies in the rat显示文摘 | Lucyna A M Agnieszka W Edyta M | 2014 | Neurotox Res2014，26，： | 1 |
| 9 | Antidepressant-like activity of the endogenous amine,1-methyl-1,2,3,4-tetrahydroisoquinoline in the behavioral despair test in the rat,and its neurochemical correlates:A comparison with the classical antidepressant,imipramine显示文摘 | Agnieszka W Edyta M Irena R Jerzy M Lucyna AM | 2013 | Eur J Pharmacol2013，700，13： | 1 |
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