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| 1 | Functional dyspepsia:The role of visceral hypersensitivity in its pathogenesis显示文摘功能,或非溃疡,消化不良(FD ) 是为到胃的肠学的工作分派的最普通的原因之一。它与重要病态被联系并且损害了生命的质量。许多当局相信那机能性消化不良和急躁的肠症候群代表一样的疾病过程的光谱的部分。FD 的病理生理学仍然保持不清楚但是几个理论包括内脏的超敏性,胃的马达机能障碍, Helicobacter pylori 感染和精神分析被建议了社会因素。在这评论,迄今为止,我们在 FD 的原因论为内脏的超敏性的角色看证据。 | John Keohane Eamonn M M Quigley | 2006 | World Journal of Gastroenterology2006，12，17： | 35 |
| 2 | The Gut Microbiota and the Liver Pathophysiological and Clinical Implications显示文摘 | Eamonn M .M. Quigley Catherine Stanton Eileen F. Murphy | 2012 | Journal of Hepatology2012，，： | 2 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Small intestinal bacterial overgrowth: roles of antibiotics, prebiotics, and probiotics显示文摘 | Eamonn M M Quigley E Y Quera R | 2006 | Gastroen Terology2006，，130： | 1 |
| 5 | Overcoming pore-pressure challenges in deepwater exploration-Multidisciplinary approach proves critical 显示文摘 | John R B Nlall J M Eamonn F D | 2003 | Offshore2003，，： | 1 |
| 6 | Functional dyspepsia and nonerosive reflux disease: Clinical interactions and their implications 显示文摘 | John Keohane Eamonn M M Quigley | 2007 | Med Gen Med2007，9，3： | 1 |
| 7 | Irritable bowel syndrome; update on pathophysiology and management 显示文摘 | Eamonn M Quigley M Orla F | 2012 | Turk J Gas troenterol2012，23，4： | 1 |
| 8 | SLIT2 axon guidancemolecule is frequently inactivated in colorectal cancer and suppres-ses growth of colorectal carcinoma cellsl显示文摘 | Ashraf D Dion M Eamonn RM | 2003 | Cancer Res2003，63，： | 1 |
| 9 | SmaU intestinal bacterial overgrowth : roles of antibiotics, prebiotics, andprobiotics 显示文摘 | Eamonn M M Quigley E Y Quera R | 2006 | Gastroen Terology2006，，130： | 1 |
| 10 | An efficient implementation of a three-dimensional microcell propagation tool for indoor and outdoor urban environments 显示文摘 | WILLIAM M O EAMONN M K PETER J C | 2000 | IEEE Transactions on Vehicular Technology2000，49，2： | 1 |
| 11 | An efficient implementation of a three -dimensional microcell propagation tool for indoor and outdoor urban environments 显示文摘 | William M O Eamonn M K Peter J C | 2000 | IEEE Transactions on Vehicular Technology2000，49，2： | 1 |
| 12 | The Use of Contact Time and the Reactive Strength Index to Optimize Fast Stretch-Shortening Cycle Training 显示文摘 | Eamonn P Flanagan Thomas M Comyns | 2008 | Strength and Condi- tioning Journal2008，30，5： | 1 |
| 13 | Metal finning: an analysis of spinning processes 显示文摘 | Eamonn Q E John M | 2000 | Journal of Materials Processing Technology2000，103，： | 1 |
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