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| 1 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 2 | Berberine inhibits androgen synthesis by interaction with aldo-keto reductase 1C3 in 22Rv1 prostate cancer cells显示文摘Aldo-keto reductase 家庭 1 成员 C3 最近在阉割抵抗的前列腺癌症被认为是一个潜在的治疗学的目标。此处,我们调查了 berberine 是否由通过 Aldo-keto reductase 家庭 1 成员 C3 的抑制减少雄激素合成推迟了阉割抵抗的前列腺癌症的前进。房间生存能力和细胞的睾丸激素内容在前列腺癌症房间被测量。Aldo-keto reductase 家庭 1 成员 C3 mRNA 和蛋白质水平被 RT-PCR 和西方的门栓分析分别地检测。有 AutoDock 工具的计算机分析与 Aldo-keto reductase 家庭 1 成员 C3 探索了 berberine 的分子的相互作用。我们发现 berberine 禁止了 22Rv1 房间增长并且减少以一种剂量依赖者方式的细胞的睾丸激素形成。Berberine 禁止了 Aldo-keto reductase 家庭 1 成员 C3 酶活动,而非影响了 mRNA 和蛋白质表情。分子的停靠学习证明 berberine 能进入 Aldo-keto reductase 家庭 1 成员 C3 和形式 π 的活跃中心; -π和氨基酸的残余 Phe306 和 Phe311 的相互作用。在结论,有 Aldo-keto reductase 家庭 1 成员 C3 的 berberine 的结构的相互作用被减少归因于 Aldo-keto reductase 家庭 1 成员 C3 酶活动的抑制和 22Rv1 前列腺癌症细胞生长的抑制细胞内部的雄激素合成。我们的结果作为铅混合物用 berberine 为 AKR1C3 禁止者的设计,研究,和发展提供试验性的基础。 | Yuantong Tian , Lijing Zhao Ye Wang Haitao Zhang Duo Xu Xuejian Zhao Yi Li Jing Li | 2016 | Asian Journal of Andrology2016，18，4： | 9 |
| 3 | Research on Water-Exit and Take-off Process for Morphing Unmanned Submersible Aerial Vehicle显示文摘This paper presents a theoretic implementation method of Morphing Unmanned Submersible Aerial Vehicle(MUSAV),which can both submerge in the water and fly in the air.Two different shapes are put forward so that the vehicle can suit both submergence and flight,considering the tremendous differences between hydrodynamic configuration and aerodynamic configuration of a vehicle.The transition of the two shapes can be achieved by using morphing technology.The water-to-air process,including water-exit,morphing,take-off and steady flight,is analyzed.The hydrodynamic and aerodynamic model of the vehicle exiting the water surface obliquely and then taking off into the air has been founded.The control strategy after morphing is analyzed and the control method is given.Numerical method is used to validate the motion model of the water-exit process.Results of simulations show the validity of the proposed model and the feasibility of MUSAV in theory. | HU Jun-hua XU Bao-wei FENG Jin-fu QI Duo YANG Jian WANG Cong | 2017 | China Ocean Engineering2017，31，2： | 8 |
| 4 | Vertically Aligned Silicon Carbide Nanowires/Boron Nitride Cellulose Aerogel Networks Enhanced Thermal Conductivity and Electromagnetic Absorbing of Epoxy Composites显示文摘With the innovation of microelectronics technology, the heat dissipation problem inside the device will face a severe test. In this work, cellulose aerogel(CA) with highly enhanced thermal conductivity(TC) in vertical planes was successfully obtained by constructing a vertically aligned silicon carbide nanowires(SiC NWs)/boron nitride(BN) network via the ice template-assisted strategy. The unique network structure of SiC NWs connected to BN ensures that the TC of the composite in the vertical direction reaches 2.21 W m^(-1) K^(-1) at a low hybrid filler loading of 16.69 wt%, which was increased by 890% compared to pure epoxy(EP). In addition, relying on unique porous network structure of CA, EP-based composite also showed higher TC than other comparative samples in the horizontal direction. Meanwhile, the composite exhibits good electrically insulating with a volume electrical resistivity about 2.35 × 10^(11) Ω cm and displays excellent electromagnetic wave absorption performance with a minimum reflection loss of-21.5 dB and a wide effective absorption bandwidth(<-10 dB) from 8.8 to 11.6 GHz. Therefore, this work provides a new strategy for manufacturing polymer-based composites with excellent multifunctional performances in microelectronic packaging applications. | Duo Pan Gui Yang Hala MAbo-Dief Jingwen Dong Fengmei Su Chuntai Liu Yifan Li Ben Bin Xu Vignesh Murugadoss Nithesh Naik Salah MEl-Bahy Zeinhom MEl-Bahy Minan Huang Zhanhu Guo | 2022 | Nano-Micro Letters2022，14，7： | 7 |
| 5 | miR164c and miR168a regulate seed vigor in rice^∞显示文摘Micro RNAs(miRNAs)are key regulators of gene expression in many important biological processes of plants.However,few miRNAs have been shown to regulate seed vigor.Here,we conducted microarray assays to analyze miRNA expression levels in seeds of the rice(Oryza sativa L.)cultivar ZR02.Results showed significant differences in the expression of 11 miRNAs between artificially aged and untreated control seeds.Among these,osa-miR164c was transcriptionally upregulated,while osamiR168 a was downregulated in artificially aged seeds;this was verified by quantitative real-time PCR analysis.Under the same aging condition,osa-miR164c overexpression in OE164c transgenic seeds and osa-miR168a silencing in MIM168a transgenic seeds of the rice cultivar Kasalath led to lower germination rates,whereas osa-miR164c silencing Rin MIM164c and osa-miR168a overexpression in OE168a resulted in higher seed germination rates compared with wild-type seeds.Meanwhile,changes in cytomembrane permeability of seeds and in the expression level of osa-miR164c target genes(OsPM27 and OsPSK5)and osamiR168a target genes(OsAGO1 and OsPTR2)under aging conditions coincided with changes in seed vigor induced by osa-miR164c and osa-miR168 a.Thus,genetic manipulation of miRNAs has important implications in the development of crop cultivars with high vigor and extended life span of seeds. | Yan Zhou Shiqi Zhou Liping Wang Duo Wu Hailan Cheng Xu Du Dandan Mao Chunlai Zhang Xiaocheng Jiang | 2020 | Journal of Integrative Plant Biology2020，62，4： | 7 |
| 6 | H2 strain attenuated live hepatitis A vaccines:protective efficacy in a hepatitis A outbreak显示文摘AIM To investigate the protective efficacy ofH2 strain attenuated live hepatitis A vaccines(H2-strain vaccines)in hepatitis A(HA)outbreaks.METHODS With the permission of theirparents,5551 pre-school and grade 1-3 primaryschool children were inoculated with 1 dose(106.5TCID50)of H2-strain vaccines in anonrandomized,controlled trial conducted inFucheng County,Hebei Province in May 1997.Another 6485 children in the same grades andcompatible in gender and age were enrolled ascontrols.Epidemiological and serological surveywas conducted to evaluate the protectiveefficacy of the vaccines.ELISA was used todetect serum IgM anti-HAV.RESULTS HA outbreak started in early May1998,peaked in the middle of the same month,and lasted about 80 days.Overall 302 HA caseswere found,192(53.58%)were 5-9 years old.One vaccinee and 25 control cases were found tohave hepatitis A,which account for 0.28%(1/356)and 5.92%(25/422)of all vaccinees andcontrols in the 14 villages,respectively.The protective efficacy of vaccines was 95.27%(95% Cl:85.83%-104.72%).In subjects testedfor anti-HAV IgM from 13 villages,1(0.40%)overt and 11(4.06%)asymptomatic HAV caseswere found in 271 vaccinees,but 21(6.69%)ofovert and asymptomatic ones were found in 314controls.CONCLUSION H2 strain vaccines were excellent in preventing overt hepatitis A, but not so effective in preventing asymptomatic hepatitis A virus infection. A booster dose might be needed to get permanent reliable immunity. | Yu Liang Zhao Zong Da Meng Zhi Yi Xu Jun Jie Guo Shao Ai Chai Cheng Gang Duo Xuan Yi Wang Jin Feng Yao Hong Bin Liu Shun Xiang Qi Hui Bin Zhu | 2000 | World Journal of Gastroenterology2000，6，6： | 7 |
| 7 | Lithium promotes recovery of neurological function after spinal cord injury by inducing autophagy显示文摘Lithium promotes autophagy and has a neuroprotective effect on spinal cord injury(SCI); however, the underlying mechanisms remain unclear. Therefore, in this study, we investigated the effects of lithium and the autophagy inhibitor 3-methyladenine(3-MA) in a rat model of SCI. The rats were randomly assigned to the SCI, lithium, 3-MA and sham groups. In the 3-MA group, rats were intraperitoneally injected with 3-MA(3 mg/kg) 2 hours before SCI. In the lithium and 3-MA groups, rats were intraperitoneally injected with lithium(LiCl; 30 mg/kg) 6 hours after SCI and thereafter once daily until sacrifice. At 2, 3 and 4 weeks after SCI, neurological function and diffusion tensor imaging indicators were remarkably improved in the lithium group compared with the SCI and 3-MA groups. The Basso, Beattie and Bresnahan locomotor rating scale score and fractional anisotropy values were increased, and the apparent diffusion coefficient value was decreased. Immunohistochemical staining showed that immunoreactivities for Beclin-1 and light-chain 3 B peaked 1 day after SCI in the lithium and SCI groups. Immunoreactivities for Beclin-1 and light-chain 3 B were weaker in the 3-MA group than in the SCI group, indicating that 3-MA inhibits lithium-induced autophagy. Furthermore, NeuN+ neurons were more numerous in the lithium group than in the SCI and 3-MA groups, with the fewest in the latter. Our findings show that lithium reduces neuronal damage after acute SCI and promotes neurological recovery by inducing autophagy. The neuroprotective mechanism of action may not be entirely dependent on the enhancement of autophagy, and furthermore, 3-MA might not completely inhibit all autophagy pathways. | Duo Zhang Fang Wang Xu Zhai Xiao-Hui Li Xi-Jing He | 2018 | Neural Regeneration Research2018，13，12： | 7 |
| 8 | Feasibility of 3.0 T diffusion-weighted nuclear magnetic resonance imaging in the evaluation of functional recovery of rats with complete spinal cord injury显示文摘Diffusion tensor imaging is a sensitive way to reflect axonal necrosis and degeneration, glial cell regeneration and demyelination following spinal cord injury, and to display microstructure changes in the spinal cord in vivo. Diffusion tensor imaging technology is a sensitive method to diagnose spinal cord injury; fiber tractography visualizes the white matter fibers, and directly displays the structural integrity and resultant damage of the fiber bundle. At present, diffusion tensor imaging is restricted to brain examinations, and is rarely applied in the evaluation of spinal cord injury. This study aimed to explore the fractional anisotropy and apparent diffusion coefficient of diffusion tensor magnetic resonance imaging and the feasibility of diffusion tensor tractography in the evaluation of complete spinal cord injury in rats. The results showed that the average combined scores were obviously decreased after spinal cord transection in rats, and then began to increase over time. The fractional anisotropy scores after spinal cord transection in rats were significantly lower than those in normal rats(P < 0.05); the apparent diffusion coefficient was significantly increased compared with the normal group(P < 0.05). Following spinal cord transection, fractional anisotropy scores were negatively correlated with apparent diffusion coefficient values(r = –0.856, P < 0.01), and positively correlated with the average combined scores(r = 0.943, P < 0.01), while apparent diffusion coefficient values had a negative correlation with the average combined scores(r = –0.949, P < 0.01). Experimental findings suggest that, as a non-invasive examination, diffusion tensor magnetic resonance imaging can provide qualitative and quantitative information about spinal cord injury. The fractional anisotropy score and apparent diffusion coefficient have a good correlation with the average combined scores, which reflect functional recovery after spinal cord injury. | Duo Zhang Xiao-hui Li Xu Zhai Xi-jing He | 2015 | Neural Regeneration Research2015，10，3： | 7 |
| 9 | Therapeutic effect of regulating autophagy in spinal cord injury: a network meta-analysis of direct and indirect comparisons显示文摘Objective:An increasing number of studies indicate that autophagy plays an important role in the pathogenesis of spinal cord injury,and that regulating autophagy can enhance recovery from spinal cord injury.However,the effect of regulating autophagy and whether autophagy is detrimental or beneficial after spinal cord injury remain unclear.Therefore,in this study we evaluated the effects of autophagy regulation on spinal cord injury in rats by direct and indirect comparison,in an effort to provide a basis for further research.Data source:Relevant literature published from inception to February 1,2018 were included by searching Wanfang,CNKI,Web of Science,MEDLINE(OvidSP),PubMed and Google Scholar in English and Chinese.The keywords included'autophagy','spinal cord injury',and'rat'.Data selection:The literature included in vivo experimental studies on autophagy regulation in the treatment of spinal cord injury(including intervention pre-and post-spinal cord injury).Meta-analyses were conducted at different time points to compare the therapeutic effects of promoting or inhibiting autophagy,and subgroup analyses were also conducted.Outcome measure:Basso,Beattie,and Bresnahan scores.Results:Of the 622 studies,33 studies of median quality were included in the analyses.Basso,Beattie,and Bresnahan scores were higher at 1 day(MD=1.80,95%CI:0.81-2.79,P=0.0004),3 days(MD=0.92,95%CI:0.72-1.13,P<0.00001),1 week(MD=2.39,95%CI:1.85-2.92,P<0.00001),2 weeks(MD=3.26,95%CI:2.40-4.13,P<0.00001),3 weeks(MD=3.13,95%CI:2.51-3.75,P<0.00001)and 4 weeks(MD=3.18,95%CI:2.43-3.92,P<0.00001)after spinal cord injury with upregulation of autophagy compared with the control group(drug solvent control,such as saline group).Basso,Beattie,and Bresnahan scores were higher at 1 day(MD=6.48,95%CI:5.83-7.13,P<0.00001),2 weeks(MD=2.43,95%CI:0.79-4.07,P=0.004),3 weeks(MD=2.96,95%CI:0.09-5.84,P=0.04)and 4 weeks(MD=4.41,95%CI:1.08-7.75,P=0.01)after spinal cord injury with downregulation of autophagy compared with the control group.Indirect comparison of upregulation and downregulation of autophagy showed no differences in Basso,Beattie,and Bresnahan scores at 1 day(MD=-4.68,95%CI:-5.840 to-3.496,P=0.94644),3 days(MD=-0.28,95%CI:-2.231-1.671,P=0.99448),1 week(MD=1.83,95%CI:0.0076-3.584,P=0.94588),2 weeks(MD=0.81,95%CI:-0.850-2.470,P=0.93055),3 weeks(MD=0.17,95%Cl:-2.771-3.111,P=0.99546)or 4 weeks(MD=-1.23,95%Cl:-4.647-2.187,P=0.98264)compared with the control group.Conclusion:Regulation of autophagy improves neurological function,whether it is upregulated or downregulated.There was no difference between upregulation and downregulation of autophagy in the treatment of spinal cord injury.The variability in results among the studies may be associated with differences in research methods,the lack of clearly defined autophagy characteristics after spinal cord injury,and the limited autophagy monitoring techniques.Thus,methods should be standardized,and the dynamic regulation of autophagy should be examined in future studies. | Duo Zhang Di Zhu Fang Wang Ji-Chao Zhu Xu Zhai Yuan Yuan Chen-Xi Li | 2020 | Neural Regeneration Research2020，15，6： | 5 |
| 10 | Analysis of severe human adenovirus infection outbreak in Guangdong Province,southern China in 2019显示文摘During 2018–2019,a severe human adenovirus(HAdV)infection outbreak occurred in southern China.Here,we screened 18 respiratory pathogens in 1704 children(≤14 years old)hospitalized with acute respiratory illness in Guangzhou,China,in 2019.In total,151 patients had positive HAdV test results;34.4%(52/151)of them exhibited severe illness.HAdV infection occurred throughout the year,with a peak in summer.The median patient age was 3.0(interquartile range:1.1–5.0)years.Patients with severe HAdV infection exhibited increases in12 clinical indexes(P≤0.019)and decreases in four indexes(P≤0.007),compared with patients exhibiting nonsevere infection.No significant differences were found in age or sex distribution according to HAdV infection severity(P>0.05);however,the distributions of comorbid disease and HAdV co-infection differed according to HAdV infection severity(P<0.05).The main epidemic types were HAdV-3(47.0%,71/151)and HAdV-7(46.4%,70/151).However,the severe illness rate was significantly higher in patients with HAdV-7(51.4%)than in patients with HAdV-3(19.7%)and other types of HAdV(20%)(P<0.001).Sequencing analysis of genomes/capsid genes of 13 HAdV-7 isolates revealed high similarity to previous Chinese isolates.A representative HAdV-7isolate exhibited a similar proliferation curve to the curve described for the epidemic HAdV-3 strain Guangzhou01(accession no.DQ099432)(P>0.05);the HAdV-7 isolate exhibited stronger virulence and infectivity,compared with HAdV-3(P<0.001).Overall,comorbid disease,HAdV co-infection,and high virulence and infectivity of HAdV-7 were critical risk factors for severe HAdV infection;these data can facilitate treatment,control,and prevention of HAdV infection. | Wenkuan Liu Shuyan Qiu Li Zhang Hongkai Wu Xingui Tian Xiao Li Duo Xu Jing Dai Shujun Gu Qian Liu Dehui Chen Rong Zhou | 2022 | Virologica Sinica2022，37，3： | 5 |
| 11 | Imidazolium ionic liquid-supported sulfonic acids:Efficient and recyclable catalysts for esterification of benzoic acid显示文摘几 imidazolium 离子的液体(IL ) 与不同阴离子支持了酸性硫酸基的酸,[C3SO3Hmim ] HSO4,[C3SO3Hmim ] BF4,[C3SO3Hmim ] PF6,并且[C3SO3Hmim ] CF3SO3,为安息香的酸的酯化作用反应作为催化剂被综合并且适用。试验性的结果显示 HSO4 的支持 IL 的酸性硫酸基的酸的包含阴离子显示出的那 imidazolium 最好的催化活动。仅仅少些[C3SO3Hmim ] HSO4 (0.3 equiv ) 适用,产品与 97% 的高产量被获得。而且,生产酉旨能被移注分开,并且催化剂能在水的移动以后被再使用。 | Yue Qin Cai Guo Qiang Yu Chuan Duo Liu Yuan Yuan Xu Wei Wang | 2012 | Chinese Chemical Letters2012，23，1： | 5 |
| 12 | Ultrathin 2D Metal–Organic Framework Nanosheets In situ Interpenetrated by Functional CNTs for Hybrid Energy Storage Device显示文摘The controllable construction of two-dimensional(2D)metal–organic framework(MOF)nanosheets with favorable electrochemical performances is greatly challenging for energy storage.Here,we design an in situ induced growth strategy to construct the ultrathin carboxylated carbon nanotubes(C-CNTs)interpenetrated nickel MOF(Ni-MOF/C-CNTs)nanosheets.The deliberate thickness and specific surface area of novel 2D hybrid nanosheets can be effectively tuned via finely controlling C-CNTs involvement.Due to the unique microstructure,the integrated 2D hybrid nanosheets are endowed with plentiful electroactive sites to promote the electrochemical performances greatly.The prepared Ni-MOF/C-CNTs nanosheets exhibit superior specific capacity of 680 C g^−1 at 1 A g^−1 and good capacity retention.The assembled hybrid device demonstrated the maximum energy density of 44.4 Wh kg^−1 at a power density of 440 W kg^−1.Our novel strategy to construct ultrathin 2D MOF with unique properties can be extended to synthesize various MOF-based functional materials for diverse applications. | Feitian Ran Xueqing Xu Duo Pan Yuyan Liu Yongping Bai Lu Shao | 2020 | Nano-Micro Letters2020，12，4： | 5 |
| 13 | Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease显示文摘Use of glucagon-like peptide-1 receptor agonist or dipeptidyl peptidase 4 inhibitor has been shown to lower the incidence of Parkinson's disease in patients with diabetes mellitus.Therefore,using these two treatments may help treat Parkinson's disease.To further investigate the mechanisms of action of these two compounds,we established a model of Parkinson's disease by treating mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and then subcutaneously injected them with the glucagon-like peptide-1 receptor agonist exendin-4 or the dipeptidyl peptidase 4 inhibitor linagliptin.We found that both exendin-4 and linagliptin reversed motor dysfunction,glial activation,and dopaminergic neuronal death in this model.In addition,both exendin-4 and linagliptin induced microglial polarization to the anti-inflammatory M2 phenotype and reduced pro-inflammatory cytokine secretion.Moreover,in vitro experiments showed that treatment with exendin-4 and linagliptin inhibited activation of the nucleotide-binding oligomerization domain-and leucine-rich-repeat-and pyrin-domaincontaining 3/caspase-1/interleukin-1βpathway and subsequent pyroptosis by decreasing the production of reactive oxygen species.These findings suggest that exendin-4 and linagliptin exert neuroprotective effects by attenuating neuroinflammation through regulation of microglial polarization and the nucleotidebinding oligomerization domain-and leucine-rich-repeat-and pyrin-domain-containing 3/caspase-1/interleukin-1βpathway in a mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.Therefore,these two drugs may serve as novel anti-inflammatory treatments for Parkinson's disease. | Hai-Yang Yu Tong Sun Zhen Wang Hong Li Duo Xu Jing An Lu-Lu Wen Jia-Yi Li Wen Li Juan Feng | 2023 | Neural Regeneration Research2023，18，8： | 4 |
| 14 | Prolonging the plasma circulation of proteins by nano- encapsulation with phosphorylcholine-based polymer显示文摘突然在 vivo 循环是到蛋白质治疗学的普遍采纳的一个主要阻碍者。经由显著地展出的一个二拍子的圆舞封装过程与基于 phosphorylcholine 的聚合物的薄层包含蛋白质产生的蛋白质 nanocapsules 延长了血浆半衰期。而且,由与类似的尺寸构造 nanocapsules 但是不同表面费用和化学,我们为延长治疗学的蛋白质的血浆半衰期表明了通用策略。在里面一在里面 vitro 实验,牛的浆液白朊(BSA ) 的四种类型 nanocapsules 在磷酸盐缓冲区与胎儿的牛的浆液(FBS ) 被孵化盐(PBS ) ;由 HeLa 房间的房间举起被监视系统地在循环期间评估表面化学的特征。单个正电子排放计算断层摄影术的断层摄影术(SPECT ) 被采用在静脉内的管理以后在血浆集中的 vivo,以及 quantification 允许 BSA nanoparticle 分发的即时观察。这研究为为临床的使用翻译大量蛋白质提供一个实际方法。 | Linlin Zhang Yang Liu Gan Liu Duo Xu Sheng Liang Xinyuan Zhu Yunfeng Lu Hui Wang | 2016 | Nano Research2016，9，8： | 4 |
| 15 | A Risk Prediction Model for In-hospital Mortality in Patients with Suspected Myocarditis显示文摘 | Duo Xu Ruo-Chi Zhao Wen-Hui Gao Han-Bin Cui | 2017 | Chinese Medical Journal2017，，7： | 4 |
| 16 | Genetic architecture and key genes controlling the diversity of oil composition in rice grains显示文摘Rice grain oil is a valuable nutrient source.However,the genetic basis of oil biosynthesis in rice grains remains unclear.In this study,we performed a genome-wide association study on oil composition and oil concentration in a diverse panel of 533 cultivated rice accessions.High variation for 11 oil-related traits was observed,and the oil composition of rice grains showed differentiation among the subpopulations.We identified 46 loci that are significantly associated with grain oil concentration or composition,16 of which were detected in three recombinant inbred line populations.Twenty-six candidate genes encoding enzymes involved in oil metabolism were identified from these 46 loci,four of which(PAL6,LIN6,MYR2,and ARA6)were found to contribute to natural variation in oil composition and to show differentiation among the subpopulations.Interestingly,population genetic analyses revealed that specific haplotypes of PAL6 and LIN6 have been selected in japonica rice.Based on these results,we propose a possible oil biosynthetic pathway in rice grains.Collectively,our results provide new insights into the genetic basis of oil biosynthesis in rice grains and can facilitate marker-based breeding of rice varieties with enhanced oil and grain quality. | Hao Zhou Duo Xia Pingbo Li Yiting Ao Xiaodong Xu Shanshan Wan Yanhua Li Bian Wu Huan Shi Kaiyue Wang Guanjun Gao Qinglu Zhang Gongwei Wang Jinghua Xiao Xianghua Li Sibin Yu Xingming Lian Yuqing He | 2021 | Molecular Plant2021，14，3： | 4 |
| 17 | 雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应显示文摘文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。 | Mengjie Hu Qiang Luo Gulimiran Alitongbieke Shuyi Chong Chenting Xu Lei Xie Xiaohui Chen Duo Zhang Yuqi Zhou Zhaokai Wang Xiaohong Ye Lijun Cai Fang Zhang Huibin Chen Fuquan Jiang Hui Fang Shanjun Yang Jie Liu Maria T.Diaz-Meco Ying Su Hu Zhou Jorge Moscat Xiangzhi Lin 张晓坤 | 2018 | 科学新闻2018，0，4： | 3 |
| 18 | Law-of-the-wall analytical formulations for Type-A turbulent boundary layers显示文摘In-depth analyses of existing direct numerical simulations(DNS)data led to a logical and important classification of generic turbulent boundary layers(TBLs),namely Type-A,-B and-C TBL,based on the distribution patterns of the time-averaged wall-shear stress.Among these types,Type-A TBL and its related law formulations were investigated in terms of the analytical velocity profiles independent on Reynolds number(Re).These formulations were benchmarked by the DNS data of turbulence on a zero-pressure-gradient flat-plate(ZPGFP).With reference to the analysis from von Karman in developing the traditional law-of-the-wall,the current study first physically distinguished the time-averaged local scale used by von Karman from the time-space-averaged scale defined in the current paper,and then derived the governing equations with the Re—independency under the time-space-averaged scales.Based on the indicator function(IDF)and TBL thickness,the sublayer partitions were quantitatively defined.The analytical formulations for entire ZPGFP TBL were derived,including the formula in the inner,buffer,semi-logarithmic(semi-log)and wake layers.The research profoundly understood the damping phenomenon and its controlling mechanism in the TBL with its associated mathematical expressions,namely the damping function under both linear and logarithmic coordinates.Based on these understandings and the quantified TBL partitions,the analytical formulations for the entire ZPGFP TBL were established and were further proved being uniform and consistent under both the time-averaged local and the time-space-averaged scales.Comparing to the traditional law,these formulations were validated by the existing DNS data with more accuracy and wider applicability.The findings advance the current understandings of the conventional TBL theory and its well-known foundation of law-of-the-wall. | Duo Wang Heng Li Bo-chao Cao Hongyi Xu | 2020 | Journal of Hydrodynamics2020，32，2： | 3 |
| 19 | Evolution and protein interactions of AP2 proteins in Brassicaceae: Evidence linking development and environmental responses显示文摘Plants have evolved a large number of transcription factors(TF), which are enriched among duplicate genes,highlighting their roles in complex regulatory networks. The APETALA2/EREBP-like genes constitute a large plant TF family and participate in development and stress responses. To probe the conservation and divergence of AP2/EREBP genes,we analyzed the duplication patterns of this family in Brassicaceae and identified interacting proteins of representative Arabidopsis AP2/EREBP proteins. We found that many AP2/EREBP duplicates generated early in Brassicaceae history were quickly lost, but many others were retained in all tested Brassicaceae species, suggesting early functional divergence followed by persistent conservation. In addition,the sequences of the AP2 domain and exon numbers were highly conserved in rosids. Furthermore, we used 16 A.thaliana AP2/EREBP proteins as baits in yeast screens and identified 1,970 potential AP2/EREBP-interacting proteins,with a small subset of interactions verified in planta. Many AP2 genes also exhibit reduced expression in an antherdefective mutant, providing a possible link to developmental regulation. The putative AP2-interacting proteins participate in many functions in development and stress responses,including photomorphogenesis, flower development, pathogenesis, drought and cold responses, abscisic acid and auxin signaling. Our results present the AP2/EREBP evolution patterns in Brassicaceae, and support a proposed interaction network of AP2/EREBP proteins and their putative interacting proteins for further study. | Liping Zeng Yue Yin Chenjiang You Qianli Pan Duo Xu Taijie Jin Bailong Zhang Hong Ma | 2016 | Journal of Integrative Plant Biology2016，58，6： | 3 |
| 20 | Therapeutic potential of dental pulp stem cell transplantation in a rat model of Alzheimer’s disease显示文摘Dental pulp stem cells are dental pulp-derived mesenchymal stem cells that originate from the neural crest.They exhibit greater potential for the treatment of nervous system diseases than other types of stem cells because of their neurogenic differentiation capability and their ability to secrete multiple neurotrophic factors.Few studies have reported Alzheimer’s disease treatment using dental pulp stem cells.Rat models of Alzheimer’s disease were established by injecting amyloid-β1–42 into the hippocampus.Fourteen days later,5×106 dental pulp stem cells were injected into the hippocampus.Immunohistochemistry and western blot assays showed that dental pulp stem cell transplantation increased the expression of neuron-related doublecortin,NeuN,and neurofilament 200 in the hippocampus,while the expression of amyloid-βwas decreased.Moreover,cognitive and behavioral abilities were improved.These findings indicate that dental pulp stem cell transplantation in rats can improve cognitive function by regulating the secretion of neuron-related proteins,which indicates a potential therapeutic effect for Alzheimer’s disease.This study was approved by the Animal Ethics Committee of Harbin Medical University,China(approval No.KY2017-132)on February 21,2017. | Xue-Mei Zhang Yuan-Jiao Ouyang Bing-Qian Yu Wei Li Mei-Yu Yu Jin-Yue Li Zhuo-Min Jiao Dan Yang Na Li Ying Shi Yun-Yun Xu Zhi-Jun He Duo Wang Hui Yue Jin Fu | 2021 | Neural Regeneration Research2021，16，5： | 3 |
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