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44篇 您的检索式:作者名="Duckles"
    题名 作者 年代 出处 被引量
1雌激素神经保护作用机制:线粒体功能的调节显示文摘大量研究表明雌激素具有神经保护作用,但其机制尚不清楚。近年来研究提示,雌激素的神经保护作用与线粒体有着密切联系。线粒体是细胞内能量和活性氧自由基(ROS)的主要来源,对细胞内信号转导、细胞存活与死亡调节等具有十分重要的影响。在生理和病理条件下,雌激素可多方面调节线粒体功能,包括影响ATP与ROS的生成、稳定线粒体膜电位、维护细胞内钙稳态,以及调节线粒体基因和蛋白表达等。本文主要从线粒体角度综述了雌激素神经保护作用及其机制。郭家彬 铁璐 Diana N Krause Sue P Duckles 李学军 2010生理科学进展2010,41,3:7
2Testosterone suppresses endothelium-dependent dilation of rat middle cerebral arteries显示文摘Gonzales RJ Krause DN Duckles SP 2004Am J Physiol Heart Circ Physiol2004,286,2:1
3Estrogen suppresses brain mitoehondrial oxidative stress in female and male rats 显示文摘Razmara A Duckles SP Krause DN 2007Brain Res2007,11,76:1
4Estrogen increases mitoehondrial efficiency and reduces oxidative stress in cerebral blood vessels显示文摘Stirone C Duckles SP Krause DN 2005Mol Pharmacol2005,68,4:1
5Chronic estrogen treatment increases levels of endothelial nitric oxide synthase protein in rat cerebral microvessels显示文摘McNeill AM Kim N Duckles SP 1999Stroke1999,30,:1
6Chronic estrogen treatment increases leves of endothelialnitric oxide synthase protein in rat cerebral microvessels显示文摘McNeil AM Kim N Duckles SP 1999Stroke1999,30,:1
7Estrogen reduces mouse cerebral artery tone through endothelial NOS-and cyclooxygenase-dependent mechanisms显示文摘Geary GG Krause DN Duckles SP 2000Am J Physiol Heart Circ Physiol2000,279,:1
817beta-Estradiol pre- vents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen-glu- cose deprivation/reperfusion显示文摘Guo J Duckles SP Weiss JH 2012Free Radic Biol Med2012,52,:1
9Hormonal modulation of endothelial NO production显示文摘Sue P Duckles Virginia M Miller 0,,06:1
10Characterization of vascular muscarinic receptors: rabbit ear artery and bovine coronary artery显示文摘Duckles SP Garcia-Villalon AL 1990J Pharmacol Exp Ther1990,253,2:1
11Characterization of muscarinic receptors of the rabbit ear artery smooth muscle and endothelium显示文摘Hynes MR Banner W Yamamura HI Duckles SP 1986J Pharmacol Exp Ther1986,238,1:1
12Estrogen suppresses brain mitochondrial oxidative stress in female and male rats 显示文摘Razmara A Duckles SP Krause DN etal 2007Brain Res2007,1176,:1
13Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral vessels显示文摘Stirone C Duckles SP Krause DN etal 2005Mol Pharmacol2005,68,:1
1417 beta-estradiol increases rat cerebrovascular prostacyclin synthesis by elevating cyclooxy- genase- 1 and prostacyclin synthase 显示文摘Ospina J A Krause D N Duckles S P 2002Stroke2002,33,2:1
15Influence of sex steroid hormones on cerebrovascular function显示文摘Krause DN Duckles SP Pelligrino DA 2006J Appl Physiol2006,101,4:1
16Estrogen suppresses brain mitoehondrial oxidative stress in female and male rats显示文摘RAZMARA A DUCKLES S P KRAUSE D N 2007Brain Res2007,1176,:1
1717β-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen-glucose deprivation/reperfusion显示文摘Guo J Duckles S P Weiss J H 0,,11:1
18Estrogen reduces mouse cerebral artery tone though endothelial NOS- and cyclooxygenase-dependent mechanisms显示文摘Geary GG Krause DN Duckles SP 2000Am J Physiol Heart Circ Physiol2000,279,2:1
19Estrogen receptor activation of phosphoinositide-3 kinase,akt,and nitric oxide signaling in cerebral blood vessels:rapid and long-term effects显示文摘Stirone C Boroujerdi A Duckles S P 2005Mol pharmacol2005,67,1:1
20Effects of simulated microgravity on vascular contractility 显示文摘Purdy RE Duckles SP Krause DN 1998J Appl Physiol1998,85,4:1
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