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| 1 | Joint TDOA, FDOA and differential Doppler rate estimation: Method and its performance analysis显示文摘Considering the estimation accuracy reduction of Frequency Difference of Arrival(FDOA) caused by relative Doppler companding, a joint Time Difference of Arrival(TDOA),FDOA and differential Doppler rate estimation method is proposed and its Cramer-Rao low bound is derived in this paper.Firstly, second-order ambiguity function is utilized to reduce the dimensionality and estimate initial TDOA and differential Doppler rate.Secondly, the TDOA estimation is updated and FDOA is obtained using cross ambiguity function, in which relative Doppler companding is compensated by the existing differential Doppler rate.Thirdly, differential Doppler rate estimation is updated using cross estimator.Theoretical analysis on estimation variance and Cramer-Rao low bound shows that the final estimation of TDOA, FDOA and differential Doppler rate performs well at both low and high signal–noise ratio, although the initial estimation accuracy of TDOA and differential Doppler rate is relatively poor under low signal–noise ratio conditions.Simulation results finally verify the theoretical analysis and show that the proposed method can overcome relative Doppler companding problem and performs well for all TDOA, FDOA and differential Doppler rate estimation. | Dexiu HU Zhen HUANG Shangyu ZHANG Jianhua LU | 2018 | Chinese Journal of Aeronautics2018，31，1： | 16 |
| 2 | Arsenic concentration in peripheral blood is correlated with efficacy of a Traditional Chinese Medicine regimen containing realgar for the treatment of myelodysplastic syndromes显示文摘OBJECTIVE:To explore the relationship between the efficacy of realgar for the treatment of myelodysplastic syndromes with multilineage dysplasia(MDS-MLD)and arsenic concentration in the peripheral blood of patients.METHODS:In this prospective study,a total of 50 MDS-MLD patients were treated with traditional Chinese drugs containing realgar for 3 months in Xiyuan Hospital from March 2018 to January 2019.Routine blood examination as well as liver and kidney function were monitored before and after treatment.The concentration of arsenic in the peripheral blood was measured using an atomic fluorescence spectrometer after treatment.The correlation between clinical effect and arsenic concentration was analyzed by Spearman’s method.RESULTS:The treatment response rate was 54%.Two patients(4%)achieved complete remission,50%(25 of 50)showed hematologic improvement,and 23 patients had stable disease(23%).No disease progression was observed.Arsenic concentration in the peripheral blood ranged from 14.60 to 85.96μg/L.Clinical efficacy was positively correlated with arsenic concentration(P<0.05).The incidence of mild adverse reactions was 16%.CONCLUSION:A relatively high concentration of arsenic in the peripheral blood may improve the clinical efficacy of realgar in MDS-MLD patients. | WANG Dexiu XU Yonggang DU Yu WANG Hongzhi LI Liu HU Xiaomei YANG Xiupeng MA Rou ZHOU Qingbing | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 3 |
| 3 | Moving target localization for multistatic passive radar using delay, Doppler and Doppler rate measurements显示文摘Time delay and Doppler shift between the echo signal and the reference signal are two most commonly used measurements in target localization for the passive radar. Doppler rate, which can be obtained from the extended cross ambiguity function, offers an opportunity to further enhance the localization accuracy. This paper considers using the measurement Doppler rate in addition to measurements of time delay and Doppler shift to locate a moving target. A closed-form solution is developed to accurately and efficiently estimate the target position and velocity.The proposed solution establishes a pseudolinear set of equations by introducing some additional variables, imposes weighted least squares formulation to yield a rough estimate, and utilizes the function relation among the target location parameters and additional variables to improve the estimation accuracy. Theoretical covariance and Cramer-Rao lower bound(CRLB) are derived and compared, analytically indicating that the proposed solution attains the CRLB. Numerical simulations corroborate this analysis and demonstrate that the proposed solution outperforms existing methods. | ZHAO Yongsheng HU Dexiu ZHAO Yongjun LIU Zhixin | 2020 | Journal of Systems Engineering and Electronics2020，31，5： | 3 |
| 4 | Effect of sodium alginate on phosphorus recovery by vivianite precipitation显示文摘There are good prospects for phosphorus recovery from excess sludge by vivianite crystallization while a large number of extracellular polymeric substances in sludge will have impact on vivianite precipitation.In this study,as a representative of extracellular polymeric substance,the effect of sodium alginate(SA)on phosphorus recovery by vivianite precipitation under different initial SA concentrations(0–800 mg/L),p H values(6.5–9.0)and Fe/P molar ratios(1:1–2.4:1)was investigated using synthetic wastewater.The results showed that SA in low concentrations(≤400 mg/L)had little inhibitory effect on the phosphorus recovery rate.However,when the concentration of SA was larger than 400 mg/L,the phosphorus recovery rate decreased significantly with increasing SA concentrations.The inhibition rate of 800 mg/L SA was about 3 times as large as that of 400 mg/L SA.It was worth noting that the inhibitory effect of SA on vivianite precipitation decreased with increasing initial p H and Fe/P molar ratios.Additionally,SA has no obvious influence on the composition of products,but the morphology of harvested crystals was transformed from branches to plates or rods in uneven sizes. | Cong Zhang Dexiu Hu Ruijie Yang Zichen Liu | 2020 | Journal of Environmental Sciences2020，32，7： | 2 |
| 5 | Linear all-optical signal processing using silicon micro-ring resonators显示文摘硅微戒指的共鸣器(MRR ) 是谁的紧缩、万用的设备周期的频率反应能为大量应用被利用。在这份报纸,我们用硅 MRR 同样被动的过滤器在线性所有光的信号处理应用上考察我们的最近的工作。我们集中于象调整格式变换那样的应用,调音的微分阶段移动(DPSK ) 解调,直接调制的激光(数据管理语言) 的调整速度改进,和独轮脚踏车搏动产生。实现极化差异电路的可能性,减少标准硅 MRR 的极化依赖,在 DPSK 解调的特别例子上被说明。 | Yunhong DING Haiyan OU Jing XU Meng XIONG Yi AN Hao HU Michael GALILI Abel Lorences RIESGO Jorge SEOANE Kresten YVIND Leif Katsuo OXENLOWE Xinliang ZHANG Dexiu HUANG Christophe PEUCHERET | 2016 | Frontiers of Optoelectronics2016，9，3： | 1 |
| 6 | Moving target localization in distributed MIMO radar with transmitter and receiver location uncertainties显示文摘In this paper, the problem of moving target localization from Bistatic Range(BR) and Bistatic Range Rate(BRR) measurements in a Multiple-Input Multiple-Output(MIMO) radar system having widely separated antennas is investigated. We consider a practically motivated scenario,where the accurate knowledge of transmitter and receiver locations is not known and only the nominal values are available for processing. With the transmitter and receiver location uncertainties,which are usually neglected in MIMO radar systems by prior studies, taken into account in the measurement model, we develop a novel algebraic solution to reduce the estimation error for moving target localization. The proposed algorithm is based on the pseudolinear set of equations and two-step weighted least squares estimation. The Cramer-Rao Lower Bound(CRLB) is derived in the presence of transmitter and receiver location uncertainties. Theoretical accuracy analysis demonstrates that the proposed solution attains the CRLB, and numerical examples show that the proposed solution achieves significant performance improvement over the existing algorithms. | Yongsheng ZHAO Dexiu HU Yongjun ZHAO Zhixin LIU | 2019 | Chinese Journal of Aeronautics2019，32，7： | 1 |
| 7 | Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties显示文摘A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC 16872.Heterologous production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 VrcB.Intriguingly,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic window.Our study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities. | Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 8 | Construction of an Optical Klystron for Synchrotron Radiation FEL显示文摘ConstructionofanOpticalKlystronforSynchrotronRadiationFELMaYouwu;LiuBo;LuYuzhu;ZhangZhaoming;ZhangFengming;ZhangLijie;ChuiTho... | Ma Youwu Liu Bo Lu Yuzhu Zhang Zhaoming Zhang Fengming Zhang Lijie Chui Thongwei Hu Jinquan Pn Dexiu Li Ge Jia Qika Lu Shengkuan(National Laboratory of Synchroltron Radiation, University of Science and Technology of China) | 1996 | 中国原子能科学研究院年报1996，，1： | 0 |
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