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| 1 | Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs显示文摘Blood-borne small non-coding(snc RNAs)are among the prominent candidates for blood-based diagnostic tests.Often,high-throughput approaches are applied to discover biomarker signatures.These have to be validated in larger cohorts and evaluated by adequate statistical learning approaches.Previously,we published high-throughput sequencing based microRNA(miRNA)signatures in Alzheimer’s disease(AD)patients in the United States(US)and Germany.Here,we determined abundance levels of 21 known circulating miRNAs in 465 individuals encompassing AD patients and controls by RT-qPCR.We computed models to assess the relation between miRNA expression and phenotypes,gender,age,or disease severity(Mini-Mental State Examination;MMSE).Of the 21 miRNAs,expression levels of 20 miRNAs were consistently de-regulated in the US and German cohorts.18 miRNAs were significantly correlated with neurodegeneration(Benjamini-Hochberg adjusted P<0.05)with highest significance for miR-532-5 p(BenjaminiHochberg adjusted P=4.8×10^-30).Machine learning models reached an area under the curve(AUC)value of 87.6%in differentiating AD patients from controls.Further,ten miRNAs were significantly correlated with MMSE,in particular miR-26a/26b-5p(adjusted P=0.0002).Interestingly,the miRNAs with lower abundance in AD were enriched in monocytes and T-helper cells,while those up-regulated in AD were enriched in serum,exosomes,cytotoxic t-cells,and B-cells.Our study represents the next important step in translational research for a miRNA-based AD test. | Nicole Ludwig Tobias Fehlmann Fabian Kern Manfred Gogol Walter Maetzler Stephanie Deutscher Simone Gurlit Claudia Schulte Anna-Katharina von Thaler Christian Deuschle Florian Metzger Daniela Berg Ulrike Suenkel Verena Keller Christina Backes Hans-Peter Lenhof Eckart Meese Andreas Keller | 2019 | Genomics, Proteomics & Bioinformatics2019，17，4： | 2 |
| 2 | Criteria for the di-agnosis of essential tremor 显示文摘 | Bain P Brin M Deuschl G | 2000 | Neurology2000，54，4： | 1 |
| 3 | Applications of magnetic cortical stimulation显示文摘 | ROSSINI P M BERARDELLI A DEUSCHL G | 1999 | Int Federation Clin Neuro physiol Electroencephalogr Clin Neurophysiol1999，52，： | 1 |
| 4 | Essential tremor显示文摘 | DEUSCHL G KOLLER W C | 2000 | Neurology2000，54，4： | 1 |
| 5 | N-acyl-(α,γ-diaminobutyric acid)n hydrazide as an efficient gene transfer vector in mammalian cells in culture显示文摘 | Trzeciak B Deuschle U | 1997 | Pharm Res1997，14，5： | 1 |
| 6 | A CFD-model Describing Filtration,Regeneration and Deposit Rearrangement Effects in Gas Filter Systems显示文摘 | Timo deuschle | 2008 | Chemical Engineering Journal2008，135，1： | 1 |
| 7 | Pains in parkinson disease-many syndromes un- der one umbrella显示文摘 | Wasner G Deuschl G | 2012 | Nat Rev Neurol2012，8，5： | 1 |
| 8 | Effects of antidepressants on glucose metabolism and diabetes mellitus type 2 in adults 显示文摘 | Deuschle M | 2013 | Curr Opin Psychiatry2013，26，1： | 1 |
| 9 | Deep brain stimulation for tremor: patient selection and evaluation显示文摘 | Deuschl G Bain P | 2002 | Mov Disord2002，17，： | 1 |
| 10 | Criteria for the diagnosis of essential tremor显示文摘 | Bain P Brin M Deuschl G | 2000 | Neurology2000，54，114： | 1 |
| 11 | Criteria for the diagnosis of essential tremor显示文摘 | Bain P Brin M Deuschl G | 2000 | Neurology2000，54，4： | 1 |
| 12 | Efficacy and safety of entacapone in Parkinson's disease patients with suboptimal levodopa response : a 6-month randomized placebo-controlled double-blind study in Germany and Austria( Celomen study) 显示文摘 | POEWE WH DEUSCHL G GORDIN A | 2002 | Acta Neurol Scand2002，105，4： | 1 |
| 13 | Genetics of essential tremon meta-analysis and review显示文摘 | Kuhlenbsumer G Hopfner F Deuschl G | 2014 | Neurology2014，82，11： | 1 |
| 14 | Presenilins are processed by caspase-type proteases 显示文摘 | Loetscher H Deuschle U Brockhaus M | 1997 | J Biol Chem1997，272，20： | 1 |
| 15 | MDS clinical diagnostic criteria for Parkinson's disease 显示文摘 | Postuma RB Berg D Stern M Poewe W Olanow CW Oertel W Obeso J Marek K Litvan I Lang AE Halliday G Goetz CG Gasser T Dubois B Chan P Bloem BR Adler CH Deuschl G | 2015 | Mov Disord2015，30，12： | 1 |
| 16 | Tetracycline-reversible silencing of eukaryotic promoters显示文摘 | Deuschle U Meyer WK Thiesen HJ | 1995 | Mol Cellul Biol1995，15，4： | 1 |
| 17 | Symptomatic and essential rhythmic palatal myoclonus 显示文摘 | Deuschl G Mischke G Schenck E | 1990 | Brain1990，113，： | 1 |
| 18 | Efficacy and safety of entacapone in Parkinson's disease patients with suboptimal levodopa response : a 6-month randomized placebo-controlled double-blind study in Germany and Austria( Celomen study) 显示文摘 | Poewe WH Deuschl G Gordin A | 2002 | Acta Neurol Scand2002，105，： | 1 |
| 19 | Antidepressant Treatment with Venlafaxine and Mirtazapine: no Effect on Serum Concen- tration of Vascular Endothelial Growth Factor(VEGF)显示文摘 | Deuschle Gilles Scharnholz | 2015 | Pharma- copsychiatry2015，48，7： | 1 |
| 20 | Translation of the RNA of cowpea severe mosaic virus in vitro and in cowpea protoplasts显示文摘 | Beier H Issinger O G Deuschle M | 1981 | General Virology1981，54，： | 1 |
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