2篇
您的检索式：作者名="Desley Neil"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intrahepatic Complement Activation, Sinusoidal Endothelial Injury, and Lactic Acidosis Are Associated With Initial Poor Function of the Liver After Transplantation显示文摘 | Michael A. Silva Darius F. Mirza Nick Murphy Douglas A. Richards Gary M. Reynolds Stephen J. Wigmore Desley A. H. Neil | 2008 | Transplantation2008，，5： | 1 |
| 2 | Risk factors of extraneural spreading in astrocytomas and oligodendrogliomas in donors with gliomas: A systematic review显示文摘BACKGROUND Patients with a history of primary brain tumors can be eligible for organ donation under extended criteria.The risk assessment of tumor transmission via organ transplant in primary brain tumors is primarily based on the assessment of tumor histotype and grade.Previous surgeries,chemo-/radiotherapy,and ventriculoperitoneal shunt placement can lead to a disruption of the blood-brain barrier,concurring to an increase in the transmission risk.AIM To investigate the role of tumor transmission risk factors in donors with oligodendrogliomas and astrocytomas.METHODS We searched PubMed and EMBASE databases for studies reporting extraneural spreading of oligoden-drogliomas and astrocytomas and extracted clinical-pathological data on the primary tumor histotype and grade,the elapsed time from the diagnosis to the onset of metastases,sites and number of metastases,prior surgeries,prior radiotherapy and/or chemotherapy,ventriculoatrial or ventriculo-peritoneal shunt placement,and the presence of isocitrate dehydrogenase 1/2 mutation and 1p/19q codeletion.Statistical analysis was performed using R software.Statistical correlation between chemotherapy or radiotherapy and the presence of multiple extra-central nervous system metastases was analyzed usingχ2 and Fischer exact test.The Kaplan-Meier method was used to evaluate the presence of a correlation between the metastasis-free time and:(1)Localization of metastases;(2)The occurrence of intracranial recurrences;and(3)The occurrence of multiple metastases.RESULTS Data on a total of 157 patients were retrieved.The time from the initial diagnosis to metastatic spread ranged from 0 to 325 mo in patients with oligodendrogliomas and 0 to 267 mo in those with astrocytomas.Respectively,19%and 39%of patients with oligodendroglioma and astrocytoma did not receive any adjuvant therapy.The most frequent metastatic sites were bone,bone marrow,and lymph nodes.The lungs and the liver were the most commonly involved visceral sites.There was no significant correlation between the occurrence of multiple metastases and the administration of adjuvant chemo-/radiotherapy.Patients who developed intracranial recurrences/metastases had a significantly longer extraneural metastasis-free time compared to those who developed extraneural metastases in the absence of any intra-central nervous system spread.CONCLUSION A long follow-up time does not exclude the presence of extraneural metastases.Therefore,targeted imaging of bones and cervical lymph nodes may improve safety in the management of these donors. | Serena Ammendola Valeria Barresi Elena Bariani Ilaria Girolami Antonia D’Errico Matteo Brunelli Massimo Cardillo Letizia Lombardini Amedeo Carraro Ugo Boggi Owen Cain Desley Neil Albino Eccher | 2022 | World Journal of Transplantation2022，12，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员