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| 1 | Multidisciplinary approach for multifocal, bilobar hepatocellular carcinoma: A case report and literature review显示文摘BACKGROUND Hepatocellular carcinoma(HCC) is the second most lethal malignancy worldwide. There has been virtually no change in the survivability of HCC in spite of improvement in therapies. Surgery is considered the ideal first, curative intervention, however most patients present in advanced stages with unresectable disease. Therefore, systemic and liver-directed non-operative therapies are initially offered to downstage the disease. To ensure optimal management, a multidisciplinary team approach is often warranted. Our case highlights the benefits of a multidisciplinary approach in a young woman with multifocal, bilobar HCC.CASE SUMMARY A 36-year-old Chinese woman with untreated hepatitis B was found to have large bilobar HCC during work up for abdominal pain. Her initial serum alphafetoprotein was significantly elevated to 311136 ng/mL. Computed tomography scan demonstrated bulky bilobar liver masses, consistent with intermediate stage HCC, Barcelona Clinic Liver Cancer Stage B. Her case was discussed and a personalized care plan was developed at the Multidisciplinary Center for Advanced Minimally Invasive Liver Oncologic Therapies at the University of Washington. She initially underwent bilobar transarterial chemoembolization with partial response of the left lobar tumor. Salvage hypofractionated proton beam radiation therapy was delivered to the right lobe followed by two additional transarterial chemoembolizations to the left lobe with good response.Finally, to remove left lobar residual disease, she was taken to the operating roomfor a left hepatectomy eleven months after her initial presentation. She continues to be without evidence of disease.CONCLUSION Coordinating the multiple HCC treatment modalities is complex and our case highlights the benefits of a multidisciplinary approach. | Kevin P Labadie Stephanie K Schaub Derek Khorsand Guy Johnson Smith Apisarnthanarax James O Park | 2019 | World Journal of Hepatology2019，11，1： | 2 |
| 2 | A biolistic approach for the transfer and expression of a gusA. reporter gene in embryogenic cultures of Pinus radiata显示文摘 | Christian Walter Dale R. Smith Marie B. Connett Lynette Grace Derek W. R. White | 1994 | Plant Cell Reports (-)1994，，2： | 1 |
| 3 | Adipocytokines, cardiovascular pathophysiology and myocardial protection显示文摘 | Christopher C.T. Smith Derek M. Yellon | 2010 | Pharmacology and Therapeutics2010，，2： | 1 |
| 4 | Technology foresight using roadmaps 显示文摘 | Derek Barker Smith D J H | 1995 | Long Range Planning1995，28，2： | 1 |
| 5 | 加快大型数据中心服务的可重构结构显示文摘数据中心的工作负载要求高计算能力、灵活性、能效和低成本。同时改善所有这些因素非常具有挑战性。为了推进数据中心超出商用服务器设计可以提供的能力,我们设计并构建了一个可组合、可重构的结构,来加速部分大型软件服务。结构的每个实例都由嵌入48台机器的半机架6×8二维环面高端Stratix V FPGA组成。每台服务器中都放置了一个FPGA,可以通过PCIe来访问,并用成对的10 Gb SAS电缆直接连接到其他FPGA。在本文中,我们描述了这种结构在1,632台服务器组(bed)的中等规模的部署,并测量了其在加快Bing搜索引擎方面的功效。我们描述了系统的要求和架构,详细介绍了关键技术挑战,以及使系统在出现故障情况下保持鲁棒性所需的解决方案,还有根据排名候选文档测量的系统性能、功率和弹性。在高负载时,一定范围内的可重构结构提高了每台服务器固定延迟分布的吞吐量排名95%——或在保持等效吞吐量时,减少29%的尾延迟。 | Andrew Putnam Adrian M.Caulfield Eric S.Chung Derek Chiou Kypros Constantinide John Demme Hadi Esmaeilzadeh Jeremy Fowers Gopi Prashanth Gopal Jan Gray Michael Haselman Scott Hauck Stephen Heil Amir Hormati Joo-Young Kim Sitaram Lanka James Larus Eric Peterson Simon Pope Aaron Smith Jason Thong Phillip Yi Xiao Doug Burger | 2015 | 中国集成电路2015，24，1： | 1 |
| 6 | Resident human hepatitis lymphocytes are phenotypically different from circulating lymphocytes显示文摘 | Suzanne Norris Clive Collins Derek G. Doherty Fiona Smith Gerry McEntee Oscar Traynor Niamh Nolan John Hegarty Cliona O’Farrelly | 1998 | Journal of Hepatology1998，，1： | 1 |
| 7 | Origins of follicular cells and ontogeny of steroidogenesis in ovine fetal ovaries显示文摘 | Jennifer L. Juengel Heywood R. Sawyer Peter R. Smith Laurel D. Quirke Derek A. Heath Stan Lun St.John Wakefield Kenneth P. McNatty | 2002 | Molecular and Cellular Endocrinology2002，，1： | 1 |
| 8 | Products and the Environment:An integrated Approach to Policy显示文摘 | Derek Smith | 1999 | European Environment1999，，9： | 1 |
| 9 | Technology foresight using roadmaps显示文摘 | Derek Barker David J.H. Smith | 1995 | Long Range Planning1995，，2： | 1 |
| 10 | Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines显示文摘 | Christoph Bock Evangelos Kiskinis Griet Verstappen Hongcang Gu Gabriella Boulting Zachary D. Smith Michael Ziller Gist F. Croft Mackenzie W. Amoroso Derek H. Oakley Andreas Gnirke Kevin Eggan Alexander Meissner | 2011 | Cell2011，，3： | 1 |
| 11 | Sirolimus in liver transplant recipients with renal dysfunction offers no advantage over low‐dose calcineurin inhibitor regimens显示文摘 | Derek DuBay Rob J. Smith Kenneth G. Qiu Gary A. Levy Leslie Lilly George Therapondos | 2008 | Liver Transpl2008，，5： | 1 |
| 12 | A signal detection study of the effects of suggested improvement on the monocular visual acuity of myopes显示文摘 | Eugene P. Sheehan Howard V. Smith Derek W. Forrest | 1982 | International Journal of Clinical and Experimental Hypnosis1982，，2： | 1 |
| 13 | Phytoplankton growth dynamics in offshore Lake Erie during mid-winter显示文摘 | Michael R. Twiss Derek E. Smith Erin M. Cafferty Hunter J. Carrick | 2014 | Journal of Great Lakes Research2014，，2： | 1 |
| 14 | First Observation of Surface Plasmon-Coupled Emission Due to LED Excitation显示文摘 | Derek S. Smith Yordan Kostov Govind Rao Ignacy Gryczynski Joanna Malicka Zygmunt Gryczynski Joseph R. Lakowicz | 2005 | Journal of Fluorescence2005，，6： | 1 |
| 15 | Technology Foresight Using Roadmaps显示文摘 | BARKER DEREK SMITH DAVID J H | 1995 | Long Range Planning1995，28，2： | 1 |
| 16 | Highly Cited Articles in Environmental and Occupational Health, 1919 - 1960 显示文摘 | Smith Derek R | 2009 | Archives of Envi- ronmental & Occupational Health2009，64，： | 1 |
| 17 | A biolistic approach for the transfer and expression of a gusA. reporter gene in embryogenic cultures of Pinus radiata显示文摘 | Christian Walter Dale R. Smith Marie B. Connett Lynette Grace Derek W. R. White | 1994 | Plant Cell Reports (-)1994，，2： | 1 |
| 18 | Indirect contact matters:Mid-flight external trunk perturbation increased unilateral anterior cruciate ligament loading variables during jump-landings显示文摘Purpose:To determine the effect of unanticipated mid-flight medial-lateral external perturbation of the upper or lower trunk on anterior cruciate ligament(ACL)loading variable s during jump-landings.Methods:Thirty-two participants performed double-leg vertical jump-landings while bilateral kinematics and kinetics were collected under 6conditions(upper or lower trunk perturbation locations;no,left,or right perturbation directions).Two customized catapult apparatuses were created to apply pushing perturbation to participants near the maximal jump height.Results:The ball contacted participants near the center of mass for the lower-trunk conditions and approximately 23 cm above the center of mass for the upper-trunk conditions.Under upper-trunk perturbation,the contralateral leg demonstrated significantly smaller knee flexion angles at initial contact and greater peak knee abduction angles,peak vertical ground reaction forces,peak knee extension moments,and peak knee adduction moments compared to other legs among all conditions.Under lower-trunk perturbation,the contralateral leg showed significantly smaller knee flexion angles at initial contact and increased peak vertical ground reaction forces and peak knee extension moments compared to legs in the no-perturbation conditions.Conclusion:Mid-flight external trunk pushing perturbation increased ACL loading variables for the leg contralateral to the perturbation.The uppertrunk perturbation resulted in greater changes in ACL loading variables compared to the lower-trunk perturbation,likely due to trunk and ipsilateral leg rotation and more laterally located center of mass relative to the contralateral leg.These findings may help us understand the mechanisms of indirect-contact ACL injuries and develop jump-landing training strategies under mid-flight trunk perturbation to better prevent ACL injury. | Yu Song Ling Li Jacob Layer Raychl Fairbanks Maddy Jenkins Gerwyn Hughes Derek Smith Margaret Wilson Qin Zhu Boyi Dai | 2023 | Journal of Sport and Health Science2023，12，4： | 0 |
| 19 | 色彩匹配中的问题显示文摘为了以数值的形式描述色彩(例如X、Y、Z),人们用分光幅射度计来得到光谱功率分布(Spectral Power Distribution,SPD)数据,再运用色彩匹配函数(color matching function,CMF)对这些数据进行运算。这些数据的准确性直接影响对视频显示器和视频数据的调整。影视业和其他对色彩准确性要求严格的行业,长期以来都依靠1931CIECMF标准。 | 刘旭阳 Joel Barsotti Derek Smith L.A.Heberlein | 2013 | 现代电影技术2013，，8： | 0 |
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