|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Structure-based design of conformationally constrained cyclic peptidomimetics to target the MLL1-WDR5 protein–protein interaction as inhibitors of the MLL1 methyltransferase activity显示文摘We described herein structure-based design,synthesis and evaluation of conformationally constrained,cyclic peptidomimetics to block the MLL1-WDR5 protein–protein interaction as inhibitors of the MLL1 histone methyltransferase activity.Our study has yielded cyclic peptidomimetics with very high binding affinities to WDR5(Kivalues <1 nmol/L) and function as antagonists of the MLL1 histone methyltransferase activity. | Hacer Karatas Shirley Y.Lee Elizabeth C.Townsend Fang Cao Jing Xu Denzil Bernard Liu Liu Yali Dou Shaomeng Wang | 2015 | Chinese Chemical Letters2015，26，4： | 3 |
| 2 | Bucklewaves显示文摘 | Denzil G Vaughn John W Hutchinson | 2006 | European Journal of Mechanics A/Solids2006，25，： | 1 |
| 3 | Modelling multinational telecommunications demand with limited data 显示文摘 | Islam T Denzil G F Meade N | 2002 | International Journal of Forecasting2002，18，4： | 1 |
| 4 | Annular pancreas: A review of its molecular embryology, genetic basis and clinical considerations显示文摘 | Denzil Etienne Alana John Christine O. Menias Robert Ward R. Shane Tubbs Marios Loukas | 2012 | Annals of Anatomy2012，，： | 1 |
| 5 | Vigorous response in plasma N-terminal atrial natriuretic peptide (NT-BNP)to acute myocardial infarction 显示文摘 | Denzil G Timothy S Richard W | 2004 | Clin Sci2004，106，2： | 1 |
| 6 | Deep-sea sediment compression curves : some controlling factors, spurious overconsolidation, predictions,and geophysical reproduction 显示文摘 | SINCLAIR B DENZIL T S | 1999 | Marine Georesources and Geotechnology1999，17，： | 1 |
| 7 | Statins and their role in acute pancreatitis: Case report and literature review显示文摘Statin induced pancreatitis has historically been considered a diagnosis of exclusion,with literature references typically in the form of case reports and observational studies. Recently,larger studies have challenged the correlations made by earlier case reports,and instead demonstrate a mild protective effect in statin users. We present a case report of likely statin induced pancreatitis in a 58-year-old male(which we have attributed to drug-drug interaction with resulting inhibition of hepatic cytochrome P450 enzymes) and have reviewed the apparent dichotomy in the available literature. | Denzil Etienne Yousef Reda | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 1 |
| 8 | Time to forge ahead:The Internet of Things for healthcare显示文摘Situated at the intersection of technology and medicine,the Internet of Things(IoT)holds the promise of addressing some of healthcare's most pressing challenges,from medical error,to chronic drug shortages,to overburdened hospital systems,to dealing with the COVID-19 pandemic.However,despite considerable recent technological advances,the pace of successful implementation of promising IoT healthcare initiatives has been slow.To inspire more productive collaboration,we present here a simple—but surprisingly underrated—problemoriented approach to developing healthcare technologies.To further assist in this effort,we reviewed the various commercial,regulatory,social/cultural,and technological factors in the development of the IoT.We propose that fog computing—a technological paradigm wherein the burden of computing is shifted from a centralized cloud server closer to the data source—offers the greatest promise for building a robust and scalable healthcare IoT ecosystem.To this end,we explore the key enabling technologies that underpin the fog architecture,from the sensing layer all the way up to the cloud.It is our hope that ongoing advances in sensing,communications,cryptography,storage,machine learning,and artificial intelligence will be leveraged in meaningful ways to generate unprecedented medical intelligence and thus drive improvements in the health of many people. | Denzil Furtado Andre F.Gygax Chien Aun Chan Ashley I.Bush | 2023 | Digital Communications and Networks2023，9，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员