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| 1 | Effect of fiber supplementation on the microbiota in critically ill patients显示文摘AIM:To determine tolerance to fiber supplementation of semi-elemental tube feeds in critically ill patients and measure its effect on colonic microbiota and fermentation.METHODS:Thirteen intensive care unit patients receiving jejunal feeding with a semi-elemental diet for predominantly necrotizing pancreatitis were studied.The study was divided into 2 parts:first,short-term (3-9 d)clinical tolerance and colonic fermentation as assessed by fecal short chain fatty acid(SCFA)concentrations and breath hydrogen and methane was measured in response to progressive fiber supplementation increasing from 4 g tid up to normal requirement levels of 8 g tid;second,4 patients with diarrhea were studied for 2-5 wk with maximal supplementation to additionally assess its influence on fecal microbiota quantitated by quantitative polymerase chain reaction (qPCR)of microbial 16S rRNA genes and Human Intestinal Tract Chip(HITChip)microarray analysis.Nearly all patients were receiving antibiotics(10/13)and acid suppressants(11/13)at some stage during the studies.RESULTS:In group 1,tolerance to progressive fiber supplementation was good with breath hydrogen and methane evidence(P=0.008 and P<0.0001,respectively)of increased fermentation with no exacerbation of abdominal symptoms and resolution of diarrhea in 2 of 4 patients.In group 2 before supplementation,fecal microbiota mass and their metabolites,SCFA,were dramatically lower in patients compared to healthy volunteers.From qPCR and HITChip analyses we calculated that there was a 97%reduction in the predominant potential butyrate producers and starch degraders.Following 2-5 wk of fiber supplementation there was a significant increase in fecal SCFA(acetate 28.4±4.1μmol/g to 42.5±3.1μmol/g dry weight,P=0.01;propionate 1.6±0.5 vs 6.22±1.1,P=0.006 and butyrate 2.5±0.6 vs 5.9±1.1,P=0.04)and microbial counts of specific butyrate producers,with resolution of diarrhea in 3 of 4 patients.CONCLUSION:Conventional management of critically ill patients,which includes the use of elemental diets and broad-spectrum antibiotics,was associated with gross suppression of the colonic microbiota and their production of essential colonic fuels,i.e.,SCFA.Our investigations show that fiber supplementation of the feeds has the potential to improve microbiota mass and function,thereby reducing the risks of diarrhea due to dysbiosis. | Stephen JD O'Keefe Junhai Ou James P DeLany Scott Curry Erwin Zoetendal H Rex Gaskins Scott Gunn | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 3 |
| 2 | Contribution of diffusion tensor imaging to delineation of gliomas and glioblastomas显示文摘 | Tropine A Vucurevic G Delani P | 2004 | Magn Reson Imaging2004，20，： | 1 |
| 3 | Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse显示文摘 | D Wes J Delany P Camet F Blohm A Truett J Scimeca | 1998 | Am J Physiol1998，，275： | 1 |
| 4 | Performance Synergies between Low-Temperature and HighTemperature Fischer-Tropsch Diesel Blends显示文摘 | Delanie L Luis P Kaveer H | 2007 | Energy&Fuels2007，21，： | 1 |
| 5 | Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake,Am显示文摘 | | 1999 | J Physiol1999，，： | 1 |
| 6 | Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake显示文摘 | Delany J P Blohm F Truett A A | 1999 | Comp Physiol1999，45，： | 1 |
| 7 | New method for GC/FID and GC-C-IRMS analysis of plasma free fatty acid concentration and isotopic enrichment显示文摘 | KANGANI C O KELLEY D E DELANY J P | 2008 | Journal of Chromatography B2008，873，1： | 1 |
| 8 | Association between Low Colonic Short-Chain Fatty Acids and High Bile Acids in High Colon Cancer Risk Populations 显示文摘 | Ou J DeLany J P Zhang M e t 01 | 2012 | Nutrition and Cancer2012，64，1： | 1 |
| 9 | Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake显示文摘 | Delany J P Blohm F Truett A A | 1999 | Comp Physiol1999，45，： | 1 |
| 10 | Effect of conjugated linoleic acid on body fat and energy metabolism in the mouse 显示文摘 | West D B Delany J P Camet P M | 1998 | Physiol1998，275，： | 1 |
| 11 | Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake显示文摘 | DELANY J P BLOHM F TRUETT A A | 1999 | Am J Physiol1999，276，： | 1 |
| 12 | Physi- cal activity in agin: comparison among young, aged, and nonage narian individuals显示文摘 | JOHANNSEN D L DELANY J P FRISARD M I | 2008 | J Appl Physiol2008，105，4： | 1 |
| 13 | Changes in body composition with conjugated linoleic acid显示文摘 | DELANY J P WEST D B | 2000 | Journal of American College of Nutrition2000，19，： | 1 |
| 14 | Identification and characterization of a novel human vanilloid receptor-like protein,VRL-2显示文摘 | Delany NS Hurle M Facer P | 2001 | Physiol Genomics2001，4，： | 1 |
| 15 | Serum and urinary markers of skeletal muscle tissue damage af- ter weight lifting exercise显示文摘 | PAUL G L DELANY J P SNOOK J T | 1989 | Eur J Appl Physiol Occup Physiol1989，58，7： | 1 |
| 16 | Trials needed to assess knee proprioception following stroke显示文摘 | Piriyaprasarth P Morris ME Delany C | 2009 | Physiotherapy Research International Physiother2009，14，1： | 1 |
| 17 | Effects of conjugated lioleic acid on body fat and energy metabolism in the mouse 显示文摘 | WEST D B DELANY J P CAMET P M | 1998 | American Journal of physical1998，275，： | 1 |
| 18 | Proteomic analysis of primary cultures of human adipose-derived stem cells:modulation by adipogenesis显示文摘 | DeLany J P Floyd Z E Zvonic S | 2005 | Mol Cell Proteomics2005，4，6： | 1 |
| 19 | Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake 显示文摘 | Delany J P | 1999 | Am J Physiol1999，，： | 1 |
| 20 | An Analysis of Case-Base Editing in a Spam Filtering System显示文摘 | Delany S J Cunningham P | 2004 | Computer Science Springer Berlin / Heidelberg2004，3155，： | 1 |
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