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| 1 | Lack of hepcidin expression attenuates steatosis and causesfibrosis in the liver显示文摘AIM: To investigate the role of key iron-regulatory protein, hepcidin in non-alcoholic fatty liver disease(NAFLD). METHODS: Hepcidin(Hamp1) knockout and floxed control mice were administered a high fat and high sucrose(HFS) or a regular control diet for 3 or 7 mo. Steatosis, triglycerides, fibrosis, protein and gene expression in mice livers were determined by histological and biochemical techniques, western blotting and realtime polymerase chain reaction. RESULTS: Knockout mice exhibited hepatic iron accumulation. Despite similar weight gains, HFS feeding induced hepatomegaly in floxed, but not knockout, mice. The livers of floxed mice exhibited higher levels of steatosis, triglycerides and c-Jun N-terminal kinase(JNK) phosphorylation than knockout mice. In contrast, a significant increase in fibrosis was observed in knockout mice livers within 3 mo of HFS administration. The hepatic gene expression levels of sterol regulatoryelement-binding protein-1c and fat-specific protein-27, but not peroxisome proliferator-activated receptoralpha or microsomal triglyceride transfer protein, were attenuated in HFS-fed knockout mice. Knockout mice fed with regular diet displayed increased carnitine palmitoyltransferase-1a and phosphoenolpyruvate carboxykinase-1 but decreased glucose-6-phosphatase expression in the liver. In summary, attenuated steatosis correlated with decreased expression of lipogenic and lipid storage genes, and JNK phosphorylation. Deletion of Hamp1 alleles per se modulated hepatic expression of beta-oxidation and gluconeogenic genes. CONCLUSION: Lack of hepcidin expression inhibits hepatic lipid accumulation and induces early development of fibrosis following high fat intake. Hepcidin and iron may play a role in the regulation of metabolic pathways in the liver, which has implications for NAFLD pathogenesis. | Sizhao Lu Robert G Bennett Kusum K Kharbanda Duygu Dee Harrison-Findik | 2016 | World Journal of Hepatology2016，8，4： | 3 |
| 2 | Enterprising nonprofits 显示文摘 | Dees J G | 1998 | Harvard Business Review1998，76，1： | 1 |
| 3 | Porcine Repro- ductive and Respiratorydrome Virus显示文摘 | Cho J G Dee S A | 2006 | Theriogenology2006，66，3： | 1 |
| 4 | Porcine reproductive and respiratory syndrome virus显示文摘 | Cho J G Dee S A | 2006 | Theriogenology2006，66，3： | 1 |
| 5 | The challenges of combining social and commercial enterprise 显示文摘 | Dees J G Elias J | 1998 | Business Ethics Quarterly1998，8，1： | 1 |
| 6 | Expression of defender against apoptotic death (DAD-1) in lr/s and Dianthus petals显示文摘 | Van Der Kop D A M Ruys G Dees D | 2003 | Physiolo- gia Plantarum2003，117，2： | 1 |
| 7 | Bistable systems with propagating fronts leading to pattern formation显示文摘 | Dee G Saarloose W | 1988 | Phys Rev Lett1988，60，25： | 1 |
| 8 | Taking social entrepreneurship seriously 显示文摘 | Dees J G | 2007 | Society2007，44，3： | 1 |
| 9 | Improved delay-range-dependent stability criteria for linear systems wiht time-varying delays 显示文摘 | Sun J Liu G P Chen J Dees D | 2010 | Automatica2010，46，2： | 1 |
| 10 | Porcine reproductive and respiratory syn- drome virus显示文摘 | CHO J G DEE S A | 2006 | Theriogenology2006，66，3： | 1 |
| 11 | Scaling social impact显示文摘 | Dees J G Anderson B B | 2004 | Stanford Social Innovation Review2004，1，： | 1 |
| 12 | Enterprising nonprofits: What do you do when traditional sources of funding fall short 显示文摘 | Dees J G | 1998 | Harvard Business Review1998，76，： | 1 |
| 13 | Porcine Rep roductive and Respiratory Syndrome Virus 显示文摘 | Cho J G Dee S A | 2006 | Theriogenology2006，66，3： | 1 |
| 14 | Porcine reproductive and respiratory syndrome virus显示文摘 | Cho J G Dee S A | 2006 | Theriogenology2006，66，3： | 1 |
| 15 | Pressurized bearings with inlet slots显示文摘 | Shires G L Dee C W | | 0，，： | 1 |
| 16 | Enterprising nonprofits显示文摘 | Dees J G | 1998 | Harvard business review1998，76，1： | 1 |
| 17 | The current state of the art of fluid bearings with discrete slot inlets显示文摘 | Dee C W Shires G L | | 0，，02： | 1 |
| 18 | Philanthropy and Enterprise: Harnessing the Pow- er of Business and Social Entrepreneurship for Development 显示文摘 | Dees J G | 2008 | Innovations: Technology Governance lobalization2008，3，3： | 1 |
| 19 | Building se- mantic scene models from unconstrained video 显示文摘 | Hannah M Dee Anthony G Cohn David C Hogg | 2012 | Computer Vi- sion and Image Understanding2012，116，3： | 1 |
| 20 | Personality Fit in NASCAR:An Evaluation of Driver-Sponsor Congruence and Its Impact on Sponsorship Effectiveness Outcomes显示文摘 | Dees W Bennett G Ferreira M | 2010 | Sport Marketing Quarterly2010，19，1： | 1 |
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