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| 1 | Alterations in the function of circulating mononuclear cells derived from patients with Crohn’s disease treated with mastic显示文摘AIM: To assess the effects of mastic administration on cytokine production of circulating mononuclear cells of patients with active Crohn's disease (CD). METHODS: The study was conducted in patients with established mildly to moderately active CD, attending the outpatient clinics of the hospital, and in healthy controls. Recruited to a 4 wk treatment with mastic caps (6 caps/d, 0.37 g/cap) were 10 patients and 8 controls, all of who successfully completed the protocol. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), macrophage migration inhibitory factor (MIF) and intracellular antioxidant glutathione (GSH) were evaluated in peripheral blood mononuclear cells (PBMC) before and after treatment. RESULTS: Treating CD patients with mastic resulted in the reduction of TNF-α secretion (2.1 ± 0.9 ng/mL vs 0.5 ± 0.4 ng/mL, P = 0.028). MIF release was signif icantly increased (1.2 ± 0.4 ng/mL vs 2.5 ± 0.7 ng/mL, P = 0.026) meaning that random migration and chemotaxis of monocytes/macrophages was inhibited. No signifi cant changes were observed in IL-6, MCP-1 and GSH concentrations. CONCLUSION: This study shows that mastic acts as an immunomodulator on PBMC, acting as a TNF-α inhibitor and a MIF stimulator. Although further double-blind, placebo-controlled studies in a large number of patients is required to clarify the role of this natural product, this f inding provides strong evidence that mastic might be an important regulator of immunity in CD. | Andriana C Kaliora Maria G Stathopoulou John K Triantaf illidis George VZ Dedoussis Nikolaos K Andrikopoulos | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | Chios mastic treatment of patients with active Crohn's disease显示文摘AIM: To evaluate the effectiveness of mastic administra-tion on the clinical course and plasma inflammatory me-diators of patients with active Crohn’s disease (CD).METHODS: This pilot study was conducted in patients with established mild to moderately active CD, attend-ing the outpatient clinics of the hospital, and in healthy controls. Ten patients and 8 controls were recruited for a 4-wk treatment with mastic caps (6 caps/d, 0.37 g/cap). All patients successfully completed the protocol. CD Ac-tivity Index (CDAI), Nutritional Risk Index (NRI), C-re-active protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), and total antioxidant potential (TAP) were evaluated in the plasma at baseline and at the end of the treatment period. Results were expressed as mean values ± SE and P < 0.05 was considered to indicate statistical significance.RESULTS: Patients exhibited significant reduction of CDAI (222.9 ± 18.7 vs 136.3 ± 12.3, P = 0.05) as com-pared to pretreament values. Plasma IL-6 was signifi-cantly decreased (21.2 ± 9.3 pg/mL vs 7.2 ± 2.8 pg/ mL, P = 0.027), and so did CRP (40.3 ± 13.1 mg/mL vs 19.7 ± 5.5, P = 0.028). TAP was significantly increased (0.15 ± 0.09 vs 0.57 ± 0.15 mmol/L uric acid, P = 0.036). No patient or control exhibited any kind of side effects. CONCLUSION: The results suggest that mastic signifi-cantly decreased the activity index and the plasma levels of IL-6 and CRP in patients with mildly to moderately ac-tive CD. Further double-blind, placebo-controlled studies in a larger number of patients are required to clarify the role of this natural product in the treatment of patients with CD. | Andriana C Kaliora Maria G Stathopoulou John K Triantafillidis George VZ Dedoussis Nikolaos K Andrikopoulos | 2007 | World Journal of Gastroenterology2007，13，5： | 7 |
| 3 | Serum transforming growth factor-β1 is related to the degree of immunoparesis in patients with multiple myeloma显示文摘 | Maria-Christina Kyrtsonis Constantina Repa George (XXXV) Z Dedoussis Athanasia Mouzaki Argyris Simeonidis Marina Stamatelou Alice Maniatis | 1998 | Medical Oncology1998，，2： | 1 |
| 4 | Glutathione depletion restores the susceptibility of cisplatin-resistant chronic myelogenous leukemia cell lines to Natural Killer cell mediated cell death via recrosis rather than apoptosis显示文摘 | Dedoussis GV Andrikopoulos AK | 2001 | Eur J Cell Biol2001，80，9： | 1 |
| 5 | Dietary antioxidants in preventing atherogenesis 显示文摘 | KALIORA A C DEDOUSSIS G V Z SCHMIDT H | 2006 | Atherosclerosis2006，187，1： | 1 |
| 6 | Genetic-algorithm-based multi-objective optimization of the build orientation in stereolithography显示文摘 | CANELLIDIS V GIANNATSIS J DEDOUSSIS V | 2009 | The International Journal of Advanced Manufacturing Technology2009，45，78： | 1 |
| 7 | Gene-diet interactions in child- hood obesityPaucity of evidence as the epidemic of childhood obesity continues to rise显示文摘 | Apoutsakis C Dedoussis GV | 2007 | Personalized Medicine2007，4，2： | 1 |
| 8 | Additive fabrication technologies applied to medicine and health care: a review显示文摘 | Giannatsis J Dedoussis V | 2013 | Int J Adv Manuf Tech2013，40，12： | 1 |
| 9 | Tumor specific cytolysis by tumor infiltrating lymphocytes in breast cancer显示文摘 | Baxevanis CN Dedoussis GV Papadopoulos NG | 1994 | Cancer1994，74，4： | 1 |
| 10 | Expression of inflamm-atory molecules and associations with BMI in children显示文摘 | Dedoussis GV Kapiri A Samara A | 2010 | Eur J Clin Invest2010，40，5： | 1 |
| 11 | Antiatherogenic effect of pistacia lentiscus via GSH restoration and down regulation of CD36 rnRNA expression显示文摘 | DEDOUSSIS GVZ KALIORA A-C PSARRAS S | 2004 | Atherosclerosis2004，174，2： | 1 |
| 12 | Natural antioxidant compounds inrisk factors for CVD显示文摘 | KALIORA A C DEDOUSSIS G V | 2007 | Pharmacological Research2007，56，2： | 1 |
| 13 | Natriuretic peptide Val7Met substitution and risk of coronary artery disease in Greek patients with familial hypercholesterolemia显示文摘 | Dedoussis G V Maumus S Skoumas J | 2006 | J Clin Lab Anal2006，20，3： | 1 |
| 14 | Natural antioxidant compounds in risk factors for CVD 显示文摘 | Kaliora A C Dedoussis G V | 2007 | Pharmacological Research2007，56，2： | 1 |
| 15 | A rare functional cardioprotective APOC3 variant has risen in fre- quency in distinct population isolates 显示文摘 | Tachmazidou I Dedoussis G Southam L | 2013 | Nat Commun2013，4，： | 1 |
| 16 | Does a short breastfeeding period protect from FTO-induced adiposity in children显示文摘 | Dedoussis GV Yannakoulia M Timpson NJ | | 0，，2： | 1 |
| 17 | Age-dependent dichotomous effect of superoxide dismutase Alal6Val polymorphism on oxidized LDL levels显示文摘 | DEDOUSSIS GV KANONI S PANAGIOTAKOS DB | 2008 | Exp Mol Med2008，40，1： | 1 |
| 18 | Additive fabrication technologies applied to medicine and health care: a review 显示文摘 | Giannatsis J Dedoussis V | 2009 | Int J Adv Manuf Technol2009，40，12： | 1 |
| 19 | A rare functional cardioprotective APOC3 variant has risen in frequency n distinct population isolates显示文摘 | Ioanna Tachmazidou George Dedoussis Lorraine Southam | 2013 | Nature communications2013，，4： | 1 |
| 20 | An associ ation between the methylenetetrahydrofolate reductase (MTHFR)C677T mutation and inflammation markers relat- ed to cardiovascular disease 显示文摘 | Dedoussis GV Panagiotakos DB Pitsavos C | 2005 | Int J Cardiol2005，100，3： | 1 |
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