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| 1 | Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an aggressive malignancy with extremely skewed ethnic and geographic distributions.Increasing evidence indicates that targeting the tumor microenvironment(TME)represents a promising therapeutic approach in NPC,highlighting an urgent need to deepen the understanding of the complex NPC TME.Here,we generated single-cell transcriptome profiles for 7581 malignant cells and 40,285 immune cells from fifteen primary NPC tumors and one normal sample.We revealed malignant signatures capturing intratumoral transcriptional heterogeneity and predicting aggressiveness of malignant cells.Diverse immune cell subtypes were identified,including novel subtypes such as CLEC9A^+dendritic cells(DCs).We further revealed transcriptional regulators underlying immune cell diversity,and cell–cell interaction analyses highlighted promising immunotherapeutic targets in NPC.Moreover,we established the immune subtype-specific signatures,and demonstrated that the signatures of macrophages,plasmacytoid dendritic cells(pDCs),CLEC9A^+DCs,natural killer(NK)cells,and plasma cells were significantly associated with improved survival outcomes in NPC.Taken together,our findings represent a unique resource providing in-depth insights into the cellular heterogeneity of NPC TME and highlight potential biomarkers for anticancer treatment and risk stratification,laying a new foundation for precision therapies in NPC. | Yu-Pei Chen Jian-Hua Yin Wen-Fei Li Han-Jie Li Dong-Ping Chen Cui-Juan Zhang Jia-Wei Lv Ya-Qin Wang Xiao-Min Li Jun-Yan Li Pan-Pan Zhang Ying-Qin Li Qing-Mei He Xiao-Jing Yang Yuan Lei Ling-Long Tang Guan-Qun Zhou Yan-Ping Mao Chen Wei Ke-Xu Xiong Hong-Bo Zhang Shi-Da Zhu Yong Hou Ying Sun Michael Dean Ido Amit Kui Wu Dong-Ming Kuang Gui-Bo Li Na Liu Jun Ma | 2020 | Cell Research2020，30，11： | 19 |
| 2 | E- valuation of the ocular hypotensive response of serotonins 5- HTIA and 5-HT2 receptor ligands in conscious ocular hyperten- sive cynomolgus monkeys显示文摘 | May JA McLaughlin MA Sharif NA HeUberg MR Dean TR | 2003 | J Pharmacol Exp Ther2003，306，1： | 1 |
| 3 | Treatment of no-reflow and impaired flow with the nitric oxide donor nitroprusside following percutaneous coronary interventions: initial human clinical experience显示文摘 | Hillegass WB Dean NA Liao L | 2001 | J Am Coll Cardiol2001，37，5： | 1 |
| 4 | Treatment of no-reflow and impaired flow with the nitric oxide donor nitroprusside following per- cutaneous coronary interventions: initial human clinical experience 显示文摘 | Hillegass WB Dean NA Liao L | 2001 | JAm CoU Cardiol2001，37，5： | 1 |
| 5 | Treatment of no-reflow and impaired flow with the nitric oxide donor nitroprusside following percutaneous coronary interventions: initial human clinical experience显示文摘 | Hillegass WB Dean NA Liao L | 2001 | JAm Coil Cardiol2001，37，5： | 1 |
| 6 | Treatment of no-reflow and impaired flow with the nitric oxide donor nitroprusside following percutaneous coronary interventions: initial human cllnical experience 显示文摘 | Hillegass WB Dean NA Liao L | 2001 | J Am Coll Cardiol2001，37，5： | 1 |
| 7 | Treatment of no - reflow and impaired flow with the nitric oxide donor nitroprusside following percutaneous coronary interventions: initialhuman clinical experience 显示文摘 | Hillegass WB Dean NA Liao L | 2001 | J Am Coll Cardiol2001，37，5： | 1 |
| 8 | Anatomic relation between the nuchal ligament and the spinal dura mater in the craniocervical region显示文摘 | Dean NA Mitchell BS | 2002 | Clin Anat2002，15，3： | 1 |
| 9 | Distribution of lens sodiumpotassium-adenosine triphosphatase显示文摘 | Delamere NA Dean WL | 1993 | Invest Oph thalmol Vis Sci1993，34，： | 1 |
| 10 | The influence of Lyn kinase on Na,K-ATPase in porcine lens epithelium 显示文摘 | Bozulic LD Dean WL Delamere NA | 2004 | Am J Physiol Cell Physiol2004，286，1： | 1 |
| 11 | The influence of amphotericin B on the sodium pump of porcine lens epithelium显示文摘 | Delamere NA Dean WL Stidam JM Moseley AE | 1996 | Am J Physiol1996，270，： | 1 |
| 12 | Isoforms of Na,KATPase in rat lens epithelium and fiber cells显示文摘 | Moseley AE Dean WL Delamere NA | 1996 | Invest Ophthalmol Vis Sci1996，37，： | 1 |
| 13 | The influence of cycloheximide on Na,K-ATPase activity in cultured human lens epithelial cells显示文摘 | Gui G Dean WL Delamere NA | 2002 | Invest Ophthalmol Vis Sci2002，43，8： | 1 |
| 14 | Regional distribution of NA,K-ATPase activity in porcine lens epithelium显示文摘 | Tamiya S Dean WL Paterson CA Delamere NA | 2003 | Invest Ophthalmol Vis Sci2003，44，10： | 1 |
| 15 | Thrombin inhibits active sodium-potassium transport in porcine lens 显示文摘 | Okafor MC Dean WL Delamere NA | 1999 | Invest Ophthalmol Vis Sci1999，42，： | 1 |
| 16 | Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxieity in PC12 cells 显示文摘 | NA L I BIN LIU DEAN E | 2007 | Journal of Ethnopharmacology2007，111，： | 1 |
| 17 | Treatment of no reflow and impaired flow with the nitric oxide donor nitroprusside following percutaneous coronary interventions:initial human clinical expe-rience显示文摘 | Hillegass WB Dean NA Liao L | 2001 | J Am Coll Cardiol2001，37，5： | 1 |
| 18 | Treatment of no-reflow and impaired flow with the nitric oxide donor nitroprusside following percutaneous coronary interventions: initial human clinical experience显示文摘 | Hillegass WB Dean NA Liao L | 2001 | J Am Coll Cardiol2001，37，： | 1 |
| 19 | Protective effects of ginsenoside Rg2 a- gainst glutamate-induced neurotoxicity in PC12 cells 显示文摘 | Na Li Bin Liu Dean E | 2007 | J Ethno- pharmacology2007，111，： | 1 |
| 20 | Influence of amphotericin B on the sodium pump of porcine lens epithalium显示文摘 | Delamre NA Dean WWL Stidam JM Moseley AE | 1996 | Am J Physio1996，270，： | 1 |
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