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| 1 | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China显示文摘Importance:Neuroblastoma is the most common extracranial malignant solid tumor in children.Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma.Objective:To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center.Methods:This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed,treated,and followed-up in the Hematology-Oncology Center of Beijing Children’s Hospital from 2007 to 2019.Results:The median age at diagnosis was 34 months;80.8%of the patients were younger than 5 years of age.Notably,243 patients(23.3%)were classified as low-risk,249 patients(23.9%)were classified as intermediate-risk,and 549(52.7%)were classified as high-risk.Furthermore,956 patients underwent surgical resections;986(94.7%)patients received chemotherapy;and 176 patients with high-risk neuroblastoma received hematopoietic stem cell transplantation.The 5-year event-free survival(EFS)rate was 91.3%and 5-year overall survival(OS)rate was 97.5%in low-risk group;in the intermediate-risk group,these rates were 85.1%and 96.7%,respectively,while they were 37.7%and 48.9%in the high-risk group(P<0.001 for both).The 5-year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014(P<0.001).In total,278 patients(26.7%)exhibited tumor relapse or progression;the median interval until relapse or progression was 14 months.Of the 233 patients who died,83%died of relapse or progression of neuroblastoma and 4.3%died of therapy-related complications.Interpretation:The 5-year OS rate was low in high-risk patients,compared with low-and intermediate-risk patients.Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma.Additional treatment strategies should be sought to improve the prognosis of patients with high-risk neuroblastoma. | Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni | 2020 | Pediatric Investigation2020，4，3： | 16 |
| 2 | Ultrasensitive skin‐like wearable optical sensors based on glass micro/nanofibers显示文摘Electronic skin,a class of wearable electronic sensors that mimic the functionalities of human skin,has made remarkable success in applications including health monitoring,human-machine interaction and electronic-biological interfaces.While electronic skin continues to achieve higher sensitivity and faster response,its ultimate performance is fundamentally limited by the nature of low-frequency AC currents.Herein,highly sensitive skin-like wearable optical sensors are demonstrated by embedding glass micro/nanofibers(MNFs)in thin layers of polydimethylsiloxane(PDMS).Enabled by the transition from guided modes into radiation modes of the waveguiding MNFs upon external stimuli,the skin-like optical sensors show ultrahigh sensitivity(1870 k·Pa^-1),low detection limit(7 mPa)and fast response(10μs)for pressure sensing,significantly exceeding the performance metrics of state-of-the-art electronic skins.Electromagnetic interference(EMI)-free detection of high-frequency vibrations,wrist pulse and human voice are realized.Moreover,a five-sensor optical data glove and a 2×2-MNF tactile sensor are demonstrated.These initial results pave the way toward a new category of optical devices ranging from ultrasensitive wearable sensors to optical skins. | Lei Zhang Jing Pan Zhang Zhang Hao Wu Ni Yao Dawei Cai Yingxin Xu Jin Zhang Guofei Sun Liqiang Wang Weidong Geng Wenguang Jin Wei Fang Dawei Di Limin Tong | 2020 | Opto-Electronic Advances2020，3，3： | 12 |
| 3 | Two haplotype-resolved,gap-free genome assemblies for Actinidia latifolia and Actinidia chinensis shed light on the regulatory mechanisms of vitamin C and sucrose metabolism in kiwifruit显示文摘Kiwifruit is a recently domesticated horticultural fruit crop with substantial economic and nutritional value,especially because of the high content of vitamin C in its fruit.In this study,we de novo assembled two telomere-to-telomere kiwifruit genomes from Actinidia chinensis var.‘Donghong’(DH)and Actinidia latifolia‘Kuoye’(KY),with total lengths of 608327852 and 640561626 bp for 29 chromosomes,respectively.With a burst of structural variants involving inversion,translocations,and duplications within 8.39 million years,the metabolite content of DH and KY exhibited differences in saccharides,lignans,and vitamins.A regulatory ERF098 transcription factor family has expanded in KY and Actinidia eriantha,both of which have ultra-high vitamin C content.With each assembly phased into two complete haplotypes,we identified allelic variations between two sets of haplotypes,leading to protein sequence variations in 26494 and 27773 gene loci and allele-specific expression of 4687 and 12238 homozygous gene pairs.Synchronized metabolome and transcriptome changes during DH fruit development revealed the same dynamic patterns in expression levels and metabolite contents;free fatty acids and flavonols accumulated in the early stages,but sugar substances and amino acids accumulated in the late stages.The AcSWEET9b gene that exhibits allelic dominance was further identified to positively correlate with high sucrose content in fruit.Compared with wild varieties and other Actinidia species,AcSWEET9b promoters were selected in red-flesh kiwifruits that have increased fruit sucrose content,providing a possible explanation on why red-flesh kiwifruits are sweeter.Collectively,these two gap-free kiwifruit genomes provide a valuable genetic resource for investigating domestication mechanisms and genome-based breeding of kiwifruit. | Xue Han Yilin Zhang Qiong Zhang Ni Ma Xiaoying Liu Wenjing Tao Zhiying Lou Caihong Zhong Xing Wang Deng Dawei Li Hang He | 2023 | Molecular Plant2023，16，2： | 3 |
| 4 | Analysis of parasitic motion in parallelogram compliant mechanism 显示文摘 | Ni Zongyue Zhang Dawei Wu Yingjun | 2010 | Precision Engineering2010，34，1： | 1 |
| 5 | UPLC–QTOF/MS-based screening and identification of the constituents and their metabolites in rat plasma and urine after oral administration of Glechoma longituba extract显示文摘 | Shumao Ni Dawei Qian Jin-ao Duan Jianming Guo Er-xin Shang Yan Shu Caifu Xue | 2010 | Journal of Chromatography B2010，，28： | 1 |
| 6 | The downregulation of ErbB3 binding protein 1 (EBP1) is associated with poor prognosis and enhanced cell proliferation in hepatocellular carcinoma显示文摘 | Baoying Hu Yicheng Xiong Runzhou Ni Lixian Wei Dawei Jiang Gang Wang Di Wu Tianxin Xu Fengbo Zhao Mingyan Zhu Chunhua Wan | 2014 | 2014 (1-2)2014，，1： | 1 |
| 7 | Efficient renal clearance of DNA tetrahedron nanopartides enables quantitative evaluation of kidney function显示文摘DNA tetrahedro n nano structure (DTN) is one of the simplest DNA nano structures and has bee n successfully applied for biose nsin g, imagi ng, and treatment of can cer. To facilitate its biomedical applications and pote ntial clinical tran slation, fun dame ntal un derstandi ng of DTN's transportation among major organs in living organisms becomes increasingly important. Here, we describe the efficient renal clearanee of DTN in healthy mice by using positron emission tomography (PET) imaging. The kidney elimination of DTN was later applied for renal function evaluation in murine models of unilateral ureteral obstruction (UUO). We further established a mathematical program of DTN to validate its changes of transportation pattern in healthy and UUO mice. We believe the establishment of pharmacokinetic profiles and mathematical model of DTN may provide in sight for future optimization of DNA nano structures for biomedical applications. | Dawei Jiang Hyung-Jun lm Madeline E. Boleyn Christopher G. England Dalong Ni Lei Kang Jonathan W. Engle Peng Huang Xiaoli Lan Weibo Cai | 2019 | Nano Research2019，12，3： | 1 |
| 8 | Analysis of parasitic motion in parallelogram compliant mechanism显示文摘 | Ni Zongyue Zhang Dawei Wu Yingjun | 2010 | Precision Engineering2010，34，1： | 1 |
| 9 | UPLC–QTOF/MS-based screening and identification of the constituents and their metabolites in rat plasma and urine after oral administration of Glechoma longituba extract显示文摘 | Shumao Ni Dawei Qian Jin-ao Duan | 2010 | Journal of Chromatography B2010，878，： | 1 |
| 10 | Dynamic Analysis of a Single-Column Platform (II)显示文摘This paper describes the study of a single-column structure used as well-head platform. In order to check the reliability of computation theory and programme, model tests have been carried out. The paper introduces the conclusion of tests and the dynamic properties of single-column platform are obtained. | Lian Gan, Ni Kan, Hu Kai Guo Dawei 2. Professor, Senior Engineer, Marine Design & Research Institute of China, Shanghai3. Senior Engineer, Marine Design & REsearch Institute of China, Shanghai4. Engineer, Marine Design & Research Institute of China, Shanghai | 1992 | China Ocean Engineering1992，7，4： | 0 |
| 11 | Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury显示文摘Acute kidney injury(AKI)leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic drugs.Here,a series of polyvinylpyrrolidone(PVP)-curcumin nanoparticles(PCurNP)are designed to meet the renal excretion threshold(~45 kDa),presenting a controllable delivery nanosystem for kidney targeting.Renal accumulation of the relatively small nanoparticles,^(89)Zr-PCurNP M10 with the diameter between 5 and 8 nm,is found to be 1.7 times and 1.8 times higher than the accumulation of^(89)Zr-PCurNP M29(20-50 nm)and M40(20-50 nm)as revealed by PET imaging.Furthermore,serum creatinine analysis,kidney tissues histology,and tubular injury scores revealed that PCurNP M10 efficiently treated cisplatin-induced AKI.Herein,PCurNP offers a novel and simple strategy for precise PET image-guided drug delivery of renal protective materials. | Hao Wei Dawei Jiang Bo Yu Dalong Ni Mengting Li Yin Long Paul A.Ellison Cerise M.Siamof Liang Cheng Todd E.Barnhart Hyung-Jun Im Faquan Yu Xiaoli Lan Xiaohua Zhu Qianjun He Weibo Cai | 2023 | Bioactive Materials2023，，1： | 0 |
| 12 | Leaf recognition using BP-RBF hybrid neural network显示文摘Plant recognition has great potential in forestry research and management.A new method combined back propagation neural network and radial basis function neural network to identify tree species using a few features and samples.The process was carried out in three steps:image pretreatment,feature extraction,and leaf recognition.In the image pretreatment processing,an image segmentation method based on hue,saturation and value color space and connected component labeling was presented,which can obtain the complete leaf image without veins and back-ground.The BP-RBF hybrid neural network was used to test the influence of shape and texture on species recogni-tion.The recognition accuracy of different classifiers was used to compare classification performance.The accuracy of the BP-RBF hybrid neural network using nine dimensional features was 96.2%,highest among all the classifiers. | Xin Yang Haiming Ni Jingkui Li Jialuo Lv Hongbo Mu Dawei Qi | 2022 | Journal of Forestry Research2022，33，2： | 0 |
| 13 | AN IMPROVED LP MODEL FOR ENERGY OPTIMIZATION OF THE INTEGRATED IRON AND STEEL PLANT WITH A COGENERATION SYSTEM IN CHINA显示文摘在有一个 cogeneration 系统的一个综合熨斗和钢植物,再循环精力连续地被搬运进 cogeneration 系统和电连续地被产生,并且他们俩不能很长时间被存储。而且,电的产生和消费是不规则的,它可以引起更意外的不平衡。因此,由优化精力利用的操作安排全部精力系统是一个关键问题,它在这二个系统在生产系统,在 cogeneration 系统的产生电和再循环的精力包括未加工的精力。在这份报纸,为在有一个 cogeneration 系统的综合的铁和钢植物的精力优化的一个改进线性编程模型被建立。改进模型集中于控制整个精力流动并且通过与一个 cogeneration 系统在一个综合熨斗和钢植物优化各种精力分发和利用在在生产系统之间的全部精力系统和 cogeneration 系统安排整个精力消费。改进模型在更高的精力利用,更低的精力费用和更低的污染排出物为最佳的操作条件提供的案例研究表演。 | Zhanglin Peng Chao Fu Keyu Zhu Qiang Zhang Dawei Ni Shanlin Yang | 2016 | Journal of Systems Science and Systems Engineering2016，25，4： | 0 |
| 14 | Disturbing cytoskeleton by engineered nanomaterials for enhanced cancer therapeutics显示文摘Cytoskeleton plays a significant role in the shape change,migration,movement,adhesion,cytokinesis,and phagocytosis of tumor cells.In clinical practice,some anti-cancer drugs achieve cytoskeletal therapeutic effects by acting on different cytoskeletal protein components.However,in the absence of cell-specific targeting,unnecessary cytoskeletal recombination in organisms would be disastrous,which would also bring about severe side effects during anticancer process.Nanomedicine have been proven to be superior to some small molecule drugs in cancer treatment due to better stability and targeting,and lower side effects.Therefore,this review summarized the recent developments of various nanomaterials disturbing cytoskeleton for enhanced cancer therapeutics,including carbon,noble metals,metal oxides,black phosphorus,calcium,silicon,polymers,peptides,and metal-organic frameworks,etc.A comprehensive analysis of the characteristics of cytoskeleton therapy as well as the future prospects and challenges towards clinical application were also discussed.We aim to drive on this emerging topic through refreshing perspectives based on our own work and what we have also learnt from others.This review will help researchers quickly understand relevant cytoskeletal therapeutic information to further advance the development of cancer nanomedicine. | Xueli Xu Shanbin Xu Jipeng Wan Diqing Wang Xinlong Pang Yuan Gao Nengyi Ni Dawei Chen Xiao Sun | 2023 | Bioactive Materials2023，，11： | 0 |
| 15 | Dynamic Analysis of a Single-Column Platform显示文摘In this paper, a single-column structure used as well-head platform is studied. The loads of wave and current exerted on the single-column will be greatly reduced, therefore the cost of the structure will be decreased. The advantages of the single-column structure compared with ordinary jacket structure are explained. A dynamic analysis of this type of structure is made and some problems related to dynamic analysis are solved. In order to check the reliability of computation theory and programme, model tests have been carried out. However, as space is limited, the conclusion of tests will be introduced in another paper. Therefore, this type of structure is applicable for proctical engineering. | Lian Gan , Ni Kan, Hu Kai and Guo Dawei Prof., Senior Engineer, Marine Design and Research Institute of China, Shanghai Senior Engineer, Marine Design and Research Institute of China, Shanghai Engineer, Marine Design and Research Institute of China, Shanghai | 1991 | China Ocean Engineering1991，6，4： | 0 |
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