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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | 2004英国高血压学会高血压治疗指南(BHS-IV):概要显示文摘在高血压领域,不断出现的新证据已日益受到关注。例如:血压可作为心血管疾病的一个危险因素;改进生活方式对于预防和治疗高血压的重要意义;不同类型药物的有效性和安全性;高危高血压患者包括糖尿病患者的治疗;心血管疾病总体危险性评估的重要性以及使用他汀类药物所获得的额外益处。 | Bryan Williams Neil R Poulter Peter S Sever Morris J Brown Mark Davis Gordon T McInnes John F Potter 邱洪 | 2004 | 英国医学杂志中文版2004，7，5： | 2 |
| 3 | Coronavirus IBV:Virus retaining spike glycopolypetide S2 but not S1 is unable to induce Virus neutralizing or hemagglutination inhibiting antibody or induce chicken tracheal protection显示文摘 | Cavanagh D davis P J Darbyshire J H R W Peters | 1986 | J Gen Virol1986，67，： | 1 |
| 4 | Risk/Reward Compensation Model for Civil Engineering Infrastructure Alliance Projects显示文摘 | Love Peter E D Davis Peter R Chevis Robert Edwards David J | 2011 | Journal of Construction Engineering and Management-ASCE2011，，137： | 1 |
| 5 | Decomposition and nutrient release from radiata pine ( Pinus radiata ) coarse woody debris显示文摘 | Girisha K Ganjegunte Leo M Condron Peter W Clinton Murray R Davis Nathalie Mahieu | 2003 | Forest Ecology and Management2003，，2： | 1 |
| 6 | Arterial pulse wave velocity, infla mmatory markers, pathological GH and IGF states, cardiovascular and cerebrovascular disease 显示文摘 | Michael R Graham Peter Evans Bruce Davies | 2008 | Vascular Health and Risk Management2008，4，6： | 1 |
| 7 | A modular vector for Agrobacterium mediated transformation of wheat显示文摘 | Peters N R Ackerman S Davis E A | 1999 | Plant Molecular Biology Reporter1999，17，： | 1 |
| 8 | The REMATCH trial: rationale, design, and end points显示文摘 | Eric A Rose Alan J Moskowitz Milton Packer Josephine A Sollano Deborah L Williams Anita R Tierney Daniel F Heitjan Paul Meier Deborah Davis Ascheim Ronald G Levitan Alan D Weinberg Lynne Warner Stevenson Peter A Shapiro Ronald M Lazar John T Watson Daniel | 1999 | The Annals of Thoracic Surgery1999，，3： | 1 |
| 9 | Characteristics of sinus rhythm electrograms at sites of ablation of ventricular tachycardia relative to all other sites: a noncontact mapping study of the entire left ventricle 显示文摘 | Schilling R J Davies DW Peters NS | 1998 | J Cardiovasc Electrophysiol1998，9，9： | 1 |
| 10 | A synthesis of carbon in international trade显示文摘 | Peters G. P. Davis S. J. Andrew R | 2012 | Biogeosciences2012，，110： | 1 |
| 11 | Arabian plate se-quence stratigraphy显示文摘 | Peter R S Casey D M Davies R B | 2004 | GeoArabia2004，9，1： | 1 |
| 12 | Novel frameshift in the seurm albumin gene results in analbuminemia through premature truncation and post translational modification显示文摘 | Davis R L Peters T Jr Brennan S O | | 0，，18： | 1 |
| 13 | Risk/Reward Compensation Model for Civil Engineering Infrastruc- ture Alliance Projects 显示文摘 | Love Peter E D Davis Peter R Chevis Robert Edwards David J | 2011 | Journal of Construction Engineering and Management - ASCE2011，137，： | 1 |
| 14 | Mapping and ablation of ventricular tachycardia with the aid of a non-contact mapping system显示文摘 | SCHILLING R J PETERS N S DAVIES D W | 1999 | Heart1999，81，： | 1 |
| 15 | A modular vector for Agrobacterium mediated transformation of wheat显示文摘 | Peters N R Ackerman S Davis E A | 1999 | Plant Molecular Biology Reporter1999，17，： | 1 |
| 16 | Simultaneous endocardial mapping in the human left ventricle using a noneontact catheter: Comparison of contact and reconstructed electrograms during sinus rhythm显示文摘 | Schilling R J Peters N Davies D W | 1998 | Circulation1998，98，： | 1 |
| 17 | A modular vector for Agrobacterium mediated transformation of wheat 显示文摘 | Peters N R Ackerman S Davis E A | 1999 | Plant Molecular Biology Reporter1999，17，： | 1 |
| 18 | A Modular Vector for Agrobacterium Mediated Transformation of Wheat显示文摘 | Peters N R Ackennan S Davis E A | 1999 | Plant molecular Biology Reporter1999，17，： | 1 |
| 19 | Budd - Chiari syndrome due to inferior vena cava obstruction 显示文摘 | Davis M Peters R Reynolds T | 1968 | Gastroenterology1968，54，： | 1 |
| 20 | A synthesis of carbon in international trade显示文摘 | Peters G Davis S Andrew R | | 0，，8： | 1 |
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