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| 1 | Microarray,SAGE and their applications to cardiovascular diseases显示文摘The wealth of DNA data generated by the human genome project coupling with recently invented high-throughput gene expression profiling techniques has dramatically sped up the process for biomedical researchers on elucidating the role of genes in human diseases. One powerful method to reveal insight into gene functions is the systematic analysis of gene expression. Two popular high-throughput gene expression technologies, microarray and Serial Analysis of Gene Expression (SAGE) are capable of producing large amounts of gene expression data with the potential of providing novel insights into fundamental disease processes, especially complex syndromes such as cardiovascular disease, whose etiologies are due to multiple genetic factors and their interplay with the environment. Microarray and SAGE have already been used to examine gene expression patterns of cell-culture, animal and human tissues models of cardiovascular diseases. In this review, we will first give a brief introduction of microarray and SAGE technologies and point out their limitations. We will then discuss the major discoveries and the new biological insightsthat have emerged from their applications to cardiovascular diseases. Finally we will touch upon potential challenges and future developments in this area. | SHUI QING YE, TERA LAVOIE, DAVID C USHER, LI Q. ZHANG1 Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA2Department of Biological Science, University of Delaware, Newark, DE 19716, USA | 2002 | Cell Research2002，12，2： | 5 |
| 2 | Ranibizumab for Diabetic Macular Edema显示文摘 | Quan Dong Nguyen David M. Brown Dennis M. Marcus David S. Boyer Sunil Patel Leonard Feiner Andrea Gibson Judy Sy Amy Chen Rundle J. Jill Hopkins Roman G. Rubio Jason S. Ehrlich | 2012 | Ophthalmology2012，，4： | 4 |
| 3 | Growth and characterization of large CdSiP 2 single crystals显示文摘 | Kevin T. Zawilski Peter G. Schunemann Thomas C. Pollak David E. Zelmon Nils C. Fernelius F. Kenneth Hopkins | 2009 | Journal of Crystal Growth2009，，： | 2 |
| 4 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 5 | US Multicenter Experience With the Wingspan Stent System for the Treatment of Intracranial Atheromatous Disease: Periprocedural Results显示文摘 | David Fiorella Elad I. Levy Aquilla S. Turk Felipe C. Albuquerque David B. Niemann Beverly Aagaard-Kienitz Ricardo A. Hanel Henry Woo Peter A. Rasmussen L Nelson Hopkins Thomas J. Masaryk Cameron G. McDougall | 2007 | Stroke2007，，3： | 1 |
| 6 | The Past, Present and Future of School Improvement: towards the Third Age 显示文摘 | David Hopkins David Reynolds | 2001 | British Educational Rese-arch Journal2001，，44： | 1 |
| 7 | Characterisation of commercial papain, bromelain, actinidin and zingibain protease preparations and their activities toward meat proteins显示文摘 | Minh Ha Alaa El-Din A. Bekhit Alan Carne David L. Hopkins | 2012 | Food Chemistry2012，，1： | 1 |
| 8 | Towards Effective School Improvement显示文摘 | David Hopkins | 1995 | School Effectiveness and School Improvement1995，，3： | 1 |
| 9 | Trophic structure in open waters of the marginal ice zone in the Scotia-Weddell confluence region during spring (1983)显示文摘 | Thomas L. Hopkins David G. Ainley José J. Torres Thomas M. Lancraft | 1993 | Polar Biology1993，，6： | 1 |
| 10 | Feasibility of a Clinical Trial of Vision Therapy for Treatment of Amblyopia显示文摘 | Don W. Lyon Kristine Hopkins Raymond H. Chu Susanna M. Tamkins Susan A. Cotter B. Michele Melia Jonathan M. Holmes Michael X. Repka David T. Wheeler Nicholas A. Sala Janette Dumas David I. Silbert | 2013 | Optometry and Vision Science2013，，： | 1 |
| 11 | Water distribution and mobility in meat during the conversion of muscle to meat and ageing and the impacts on fresh meat quality attributes — A review显示文摘 | Kelly L. Pearce Katja Rosenvold Henrik J. Andersen David L. Hopkins | 2011 | Meat Science2011，，2： | 1 |
| 12 | WINGSPAN IN-STENT RESTENOSIS AND THROMBOSIS: INCIDENCE, CLINICAL PRESENTATION, AND MANAGEMENT显示文摘 | Elad I. Levy Aquilla S. Turk Felipe C. Albuquerque David B. Niemann Beverly Aagaard-Kienitz Lee Pride Phil Purdy Babu Welch Henry Woo Peter A. Rasmussen L. Nelson Hopkins Thomas J. Masaryk Cameron G. McDougall David J. Fiorella | 2007 | Neurosurgery2007，，3： | 1 |
| 13 | 管道检测和修复显示文摘根据从新近项目中获得的经验对管道的检测和修复技术进行了回顾,并推荐了一种计划管道检测和修复的简单方法。讨论了不同检测方法的可行性和实用性,包括带缆清管器、智能清管器、超声波系统和磁漏检测法,还讨论了检测计划中涉及到的工程、实践、安全、合约以及后勤问题等。 | Roland Palmer-Jones Dr. David Eyre Steve Mckenny Dr. Phil Hopkins | 2005 | 油气储运2005，24，B12： | 1 |
| 14 | US Wingspan Registry: 12-Month Follow-Up Results显示文摘 | David J. Fiorella Aquilla S. Turk Elad I. Levy G. Lee Pride Henry H. Woo Felipe C. Albuquerque Babu G. Welch David B. Niemann Beverly Aagaard-Kienitz Peter A. Rasmussen L. Nelson Hopkins Thomas J. Masaryk Cameron G. McDougall | 2011 | Stroke2011，，7： | 1 |
| 15 | The Relationship Between Plasma Osteoprotegerin Levels and Coronary Artery Calcification in Uncomplicated Type 2 Diabetic Subjects显示文摘 | Dhakshinamurthy Vijay Anand Avijit Lahiri Eric Lim David Hopkins Roger Corder | 2006 | Journal of the American College of Cardiology2006，，9： | 1 |
| 16 | Infant Feeding in the Second 6 Months of Lit'e Related to Iron Status z An Observational Study E显示文摘 | Hopkins David | 2007 | Arch Dis Child2007，92，10： | 1 |
| 17 | Promoting microbial immobilization of soil nitrogen during restoration of abandoned agricultural fields by organic additions显示文摘 | Tibor Szili-Kovács Katalin T?r?k Emma L. Tilston David W. Hopkins | 2007 | Biology and Fertility of Soils2007，，6： | 1 |
| 18 | Water distribution and mobility in meat during the conversion of muscle to meat and ageing and the impacts on fresh meat quality attributes — A review显示文摘 | Kelly L. Pearce Katja Rosenvold Henrik J. Andersen David L. Hopkins | 2011 | Meat Science2011，，2： | 1 |
| 19 | Phase 2 Clinical Trial of a Vaginal Mucosal Vaccine for Urinary Tract Infeetions显示文摘 | Uehling David T Hopkins | 2003 | J Urol2003，170，3： | 1 |
| 20 | Post-mortem modelling of pH and temperature in related lamb carcases显示文摘 | Remy J. van de Ven Kelly L. Pearce David L. Hopkins | 2012 | Meat Science2012，，： | 1 |
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