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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | Gastric peritoneal carcinomatosis-a retrospective review显示文摘AIM To characterize patients with gastric peritoneal carcinomatosis(PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of care.METHODS We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a single tertiary referral centre.RESULTS We studied a total of 271 patients with a median age of 63.8 years and median follow-up duration of 5.1 mo. The majority(n = 217, 80.1%) had the peritoneum as the only site of metastasis at initial presentation. Palliative systemic chemotherapy was eventually planned for 175(64.6%) of our patients at initial presentation, of which 171 were initiated on it. Choice of first-line regime was in accordance with the National Comprehensive Cancer Network Guidelines for Gastric Cancer Treatment. Thesepatients underwent a median of one line of chemotherapy, completing a median of six cycles in total. Chemotherapy disruption due to unplanned hospitalizations occurred in 114(66.7%), while cessation of chemotherapy occurred in 157(91.8%), with 42 cessations primarily attributable to PC-related complications. Patients who had initiation of systemic chemotherapy had a significantly better median overall survival than those who did not(10.9 mo vs 1.6 mo, P < 0.001). Of patients who had initiation of systemic chemotherapy, those who experienced any disruptions to chemotherapy due to unplanned hospitalizations had a significantly worse median overall survival compared to those who did not(8.7 mo vs 14.6 mo, P < 0.001).CONCLUSION Gastric PC carries a grim prognosis with a clinical course fraught with disease-related complications which may attenuate any survival benefit which palliative systemic chemotherapy may have to offer. As such, investigational use of regional therapies is warranted and required validation in patients with isolated PC to maximize their survival outcomes in the long run. | Hwee Leong Tan Claramae Shulyn Chia Grace Hwei Ching Tan Su Pin Choo David Wai-Meng Tai Clarinda Wei Ling Chua Matthew Chau Hsien Ng Khee Chee Soo Melissa Ching Ching Teo | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 6 |
| 3 | Hepatitis B virus infection and fatty liver in the general population显示文摘 | Vincent Wai-Sun Wong Grace Lai-Hung Wong Winnie Chiu-Wing Chu Angel Mei-Ling Chim Arlinking Ong David Ka-Wai Yeung Karen Kar-Lum Yiu Shirley Ho-Ting Chu Hoi-Yun Chan Jean Woo Francis Ka-Leung Chan Henry Lik-Yuen Chan | 2011 | Journal of Hepatology2011，，3： | 3 |
| 4 | The synthetic form of a novel chicken β-defensin identified in silico is predominantly active against intestinal pathogens显示文摘 | Rowan Higgs David J. Lynn Susan Gaines Jessica McMahon Joanna Tierney Tharappel James Andrew T. Lloyd Grace Mulcahy Cliona O’Farrelly | 2005 | Immunogenetics (-)2005，，1： | 3 |
| 5 | Hepatic venous pressure gradient predicts development of hepatocellular carcinoma independently of severity of cirrhosis显示文摘 | Cristina Ripoll Roberto J. Groszmann Guadalupe Garcia-Tsao Jaime Bosch Norman Grace Andrew Burroughs Ramon Planas Angels Escorsell Juan Carlos Garcia-Pagan Robert Makuch David Patch Daniel S. Matloff | 2009 | Journal of Hepatology2009，，5： | 3 |
| 6 | Community-based lifestyle modification programme for non-alcoholic fatty liver disease: A randomized controlled trial显示文摘 | Vincent Wai-Sun Wong Ruth Suk-Mei Chan Grace Lai-Hung Wong Bernice Ho-Ki Cheung Winnie Chiu-Wing Chu David Ka-Wai Yeung Angel Mei-Ling Chim Jennifer Wing-Yan Lai Liz Sin Li Mandy Man-Mei Sea Francis Ka-Leung Chan Joseph Jao-Yiu Sung Jean Woo Henry Lik-Yue | 2013 | Journal of Hepatology2013，，3： | 2 |
| 7 | Novel inflammatory biomarkers of portal pressure in compensated cirrhosis patients显示文摘 | Martina Buck Guadalupe Garcia‐Tsao Roberto J. Groszmann Caitlin Stalling Norman D. Grace Andrew K. Burroughs David Patch Daniel S. Matloff Paul Clopton Mario Chojkier | 2014 | Hepatology2014，，3： | 2 |
| 8 | <ce:link locator='fx1'/> Hepatic Venous Pressure Gradient Predicts Clinical Decompensation in Patients With Compensated Cirrhosis显示文摘 | Cristina Ripoll Roberto Groszmann Guadalupe Garcia–Tsao Norman Grace Andrew Burroughs Ramon Planas Angels Escorsell Juan Carlos Garcia–Pagan Robert Makuch David Patch Daniel S. Matloff Jaime Bosch | 2007 | Gastroenterology2007，，2： | 2 |
| 9 | Hepatic Venous Pressure Gradient Predicts Clinical Decompensation in Patients With Compensated Cirrhosis显示文摘 | Cristina Ripoll Roberto Groszmann Guadalupe Garcia–Tsao Norman Grace Andrew Burroughs Ramon Planas Angels Escorsell Juan Carlos Garcia–Pagan Robert Makuch David Patch Daniel S. Matloff Jaime Bosch | 2007 | Gastroenterology2007，，： | 2 |
| 10 | COOPERATIVE DIRECTIONAL INTER-CELL HANDOVER SCHEME IN HIGH ALTITUDE PLATFORM COMMUNICATIONS SYSTEMS显示文摘A novel Cooperative Directional inter-cell Handover Scheme(CDHS) for High Altitude Platform(HAP) communications systems is proposed,in which the handover target cell and the two cells adjacent to this handover target cell work cooperatively to exploit the traffic fluctuation to improve handover performance.Users in the overlap area of the overloaded handover target cell will be forced to handover directionally before their optimal handover boundary in order to free up resources for the handover calls which would otherwise be dropped due to the shortage of resources and queue time out.Simulation results show that the handover call dropping probability is greatly reduced(at least 60%) compared with the general queue handover scheme,with little performance reduction to the call blocking probability,and the Not in the Best Cell(NBC) average time is only increased moderately.Moreover,an optimal cell radius can be achieved for a specific platform speed by minimizing the unified system performance,which is the linear combination of the handover call dropping probability and the NBC average time. | Li Shufeng Wang Lijie David Grace Ma Dongtang | 2011 | Journal of Electronics(China)2011，28，2： | 2 |
| 11 | Non-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers显示文摘 | Jiayun Shen Henry Lik-Yuen Chan Grace Lai-Hung Wong Paul Cheung-Lung Choi Anthony Wing-Hung Chan Hoi-Yun Chan Angel Mei-Ling Chim David Ka-Wai Yeung Francis Ka-Leung Chan Jean Woo Jun Yu Winnie Chiu-Wing Chu Vincent Wai-Sun Wong | 2012 | Journal of Hepatology2012，，6： | 2 |
| 12 | Mod-ernization Milestone:Observing the First GPS Satellitewith an L5 Payload显示文摘 | Grace Xingxin Gao Liang Heng David De Lorenzo | 2009 | Inside GNSS Magazine2009，，56： | 1 |
| 13 | Validation of 3D Ultrasound Vessel Wall Volume: An Imaging Phenotype of Carotid Atherosclerosis显示文摘 | Micaela Egger J. David Spence Aaron Fenster Grace Parraga | 2007 | Ultrasound in Medicine & Biology2007，，6： | 1 |
| 14 | Dietary Intervention to Reverse Carotid Atherosclerosis显示文摘 | Iris Shai J. David Spence Dan Schwarzfuchs Yaakov Henkin Grace Parraga Assaf Rudich Aaron Fenster Christiane Mallett Noah Liel-Cohen Amir Tirosh Arkady Bolotin Joachim Thiery Georg Martin Fiedler Matthias Blüher Michael Stumvoll Meir J. Stampfer | 2010 | Circulation2010，，10： | 1 |
| 15 | Targeted hepatitis C screening among ex‐injection drug users in the community显示文摘 | Vincent Wai‐Sun Wong Grace Lai‐Hung Wong Angel Mei‐Ling Chim Tsz‐Fai Cheng Shirley Wing‐Yan Cheung Carol Man‐Sze Lai Kylie Joan‐Yi Szeto Sharon Tsang Stephen Ho‐Chun Wu Kenneth Kar‐Lung Yan Alex Yui Hui Desmond Chi‐Him Yiu Brian Bing‐Ying Wu David Cheung | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 16 | Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry,Vaccinium angustifolium Aiton显示文摘 | Mary H Grace David M Ribnicky Peter Kuhn | 2009 | Phytomedicine2009，16，5： | 1 |
| 17 | Understanding participation in e-learning in organi- zations : A largescale empirical study of employees 显示文摘 | Thomas N Garavan Ronan Carbery Grace O' Malley David O' Donnell | 2010 | Interna- tional Journal of Training and Development2010，14，3： | 1 |
| 18 | Integrating users into the wider broadband network via high altitude platforms显示文摘 | David Grace Myles H Capstick Mihael Mohorcic | 2005 | IEEE Wireless Communications2005，12，5： | 1 |
| 19 | The synthesis of novel hybrid monomers显示文摘 | Grace Y N Mark G L David H S | 1998 | Aust J Chem1998，51，： | 1 |
| 20 | A new classification of Cyperaceae (Poales) supported by phylogenomic data显示文摘Cyperaceae(sedges)are the third largest monocot family and are of considerable economic and ecological importance.Sedges represent an ideal model family to study evolutionary biology due to their species richness,global distribution,large discrepancies in lineage diversity,broad range of ecological preferences,and adaptations including multiple origins of C4 photosynthesis and holocentric chromosomes.Goetghebeur′s seminal work on Cyperaceae published in 1998 provided the most recent complete classification at tribal and generic level,based on a morphological study of Cyperaceae inflorescence,spikelet,flower,and embryo characters,plus anatomical and other information.Since then,several family-level molecular phylogenetic studies using Sanger sequence data have been published.Here,more than 20 years after the last comprehensive classification of the family,we present the first family-wide phylogenomic study of Cyperaceae based on targeted sequencing using the Angiosperms353 probe kit sampling 311 accessions.In addition,62 accessions available from GenBank were mined for overlapping reads and included in the phylogenomic analyses.Informed by this backbone phylogeny,a new classification for the family at the tribal,subtribal,and generic levels is proposed.The majority of previously recognized suprageneric groups are supported,and for the first time,we establish support for tribe Cryptangieae as a clade including the genus Koyamaea.We provide a taxonomic treatment including identification keys and diagnoses for the 2 subfamilies,24 tribes,and 10 subtribes,and basic information on the 95 genera.The classification includes five new subtribes in tribe Schoeneae:Anthelepidinae,Caustiinae,Gymnoschoeninae,Lepidospermatinae,and Oreobolinae. | Isabel Larridon Alexandre R.Zuntini Étienne Léveillé-Bourret Russell L.Barrett Julian R.Starr AMuthama Muasya Tamara Villaverde Kenneth Bauters Grace E.Brewer Jeremy J.Bruhl Suzana M.Costa Tammy L.Elliott Niroshini Epitawalage Marcial Escudero Isabel Fairlie Paul Goetghebeur Andrew LHipp Pedro Jiménez-Mejías Izai ABSabino Kikuchi Modesto Luceño JoséIgnacio Márquez-Corro Santiago Martín-Bravo Olivier Maurin Lisa Pokorny Eric HRoalson Ilias Semmouri David A.Simpson Daniel Spalink WWayt Thomas Karen L.Wilson Martin Xanthos Félix Forest William J.Baker | 2021 | Journal of Systematics and Evolution2021，59，4： | 1 |
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