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| 1 | Safety of tirofiban and dual antiplatelet therapy in treating intracranial aneurysms显示文摘Background Endovascular treatment of intracranial aneurysms usually involves stent-assisted coiling(SAC)and flow diverters.Glycoprotein IIb/IIIa inhibitors such as tirofiban and dual antiplatelet therapy(DAPT)are required to prevent thromboembolic complications afterwards.We sought to determine the safety of tirofiban and DAPT in these cases.Methods We conducted a retrospective analysis of our database for patients with intracranial aneurysms who underwent SAC or flow diversion.The tirofiban-DAPT protocol used is described.Data regarding duration of infusion,placement of external ventricular devices(EVDs),complications,haemoglobin levels and platelet count before and 24 hours after antiplatelet therapy were collected and analysed.results One-hundred and forty-one patients with 148 aneurysms/procedures were included.110 aneurysms were treated acutely and 38 electively.Minor and major haemorrhagic events were recognised in 20%(30/148)aneurysms.Only 5(3.4%)intracerebral haemorrhages were symptomatic:3 cortical/SAH and 2 EVD-related.The average blood volume in symptomatic haemorrhages was 24.8 cc versus 5.42 cc in asymptomatic haemorrhages(p=0.002).The rate of EVD-related haemorrhages was 15.7%(19/121)and only 2(1.7%)were symptomatic.Most haemorrhagic events occurred in ruptured aneurysms(90.1%,p=0.01).No significant change in platelet count or haemoglobin levels before and 24 hours after administration of tirofiban and DAPT was documented.Concomitant administration of heparin did not increase haemorrhagic events.Conclusion The use of the GP IIb/IIIa inhibitors tirofiban and DAPT in this series was safe.Tirofiban and DAPT did not affect platelet count or haemoglobin levels and did not increase rate of symptomatic haemorrhages or thromboembolic complications. | Edgar A Samaniego Emilee Gibson Daichi Nakagawa Santiago Ortega-Gutierrez Mario Zanaty Jorge A Roa Pascal Jabbour David M Hasan | 2019 | Stroke & Vascular Neurology2019，4，1： | 17 |
| 2 | Ranibizumab for Diabetic Macular Edema显示文摘 | Quan Dong Nguyen David M. Brown Dennis M. Marcus David S. Boyer Sunil Patel Leonard Feiner Andrea Gibson Judy Sy Amy Chen Rundle J. Jill Hopkins Roman G. Rubio Jason S. Ehrlich | 2012 | Ophthalmology2012，，4： | 4 |
| 3 | 新型光室结构的主流式NDIR呼吸CO2监测系统显示文摘针对主流式非分散红外(NDIR)呼吸CO2监测系统灵敏度及信噪比低下的问题,提出利用复合抛物面聚光器(CPC)提升监测系统性能的方法。利用ZEMAX模拟光室并优化CPC和常用的圆管聚光器以及锥形聚光器,采用单光源双光路的主流式一体化方法进行监测系统的气室设计,以STM32F100为主控芯片实现硬件系统控制,对具有不同光室结构的监测系统进行CO2浓度标定和实时人体呼吸检测实验,获取其CO2浓度与系统输出信号的对应关系和CO2波形图。结果表明,CPC光室其模拟光学效率为4.3%,比常用的聚光器最高可提升89.77倍;装有CPC的监测系统其灵敏度与信噪比为8.9407、24.65,比装有常用聚光器的系统的灵敏度最高可提升3.811倍、信噪比提升1.926倍;并且安装CPC的系统运行稳定,响应快,能够实时的反应出被测者的呼吸CO2波形图。 | 熊涛 高明(指导) Des Gibson David Hutson | 2020 | 红外与激光工程2020，49，6： | 4 |
| 4 | MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development显示文摘 | Ryan M. O’Connell Daniel Kahn William S.J. Gibson June L. Round Rebecca L. Scholz Aadel A. Chaudhuri Melissa E. Kahn Dinesh S. Rao David Baltimore | 2010 | Immunity2010，，4： | 3 |
| 5 | Will MOOCs Transform Learning and Teaching in Higher Education?Engagement and Course Retention in On- line Learning provision 显示文摘 | Sara Isabella de Freitas John Morgan David Gibson | 2015 | British Journal of Educational Technology2015，，46： | 1 |
| 6 | Oral staphylococcal mucositis显示文摘 | John Gibson David Wray Jeremy Bagg | 2000 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology2000，，2： | 1 |
| 7 | High levels of unprotected sex with men and women among men who have sex with men:a potential bridge of HIV transmission in Beijing,China显示文摘 | Kyung Lee Choi David R Gibson | 2004 | AIDS Education and Prevention2004，16，1： | 1 |
| 8 | Robotic equipment for pipeline repair显示文摘 | David Gibson Kevin Barratt Jan Paterson | 1995 | Materials Engineering ASME1995，3，2： | 1 |
| 9 | How Cost-Elastic Are Remittances? Estimates from Tongan Migrants in New Zealand 显示文摘 | Gibson John David McKenzie and Halahingano Rohorua | 2006 | Pacific and Asian Journal of Energy2006，21，1： | 1 |
| 10 | Ultrasonication Extraction and Solid Phase Extraction Clean-up for Determination of US EPA 16 Priority Pollutant Polycyclic Aromatic Hydrocarbons in Soils by Reversed-phase Liquid Chromatography with Ultraviolet Absorption Detection显示文摘 | Fusheng Sun David Littlejohn Mark David Gibson | 1998 | Analytica Chimica Acta1998，364，： | 1 |
| 11 | Delayed-Enhancement Cardiovascular Magnetic Resonance Coronary Artery Wall Imaging显示文摘 | Susan B. Yeon Adeel Sabir Melvin Clouse Pedro O. Martinezclark Dana C. Peters Thomas H. Hauser C. Michael Gibson Reza Nezafat David Maintz Warren J. Manning René M. Botnar | 2007 | Journal of the American College of Cardiology2007，，5： | 1 |
| 12 | Randomized comparison between low-pressure laparoscopic cholecystectomy and gasless laparoscopic cholecystectomy显示文摘 | Vezakis A Davides D Gibson JS | 1999 | Surg Endosc1999，13，9： | 1 |
| 13 | Clinical Implications and Correlates of Q Waves in Patients With ST ‐Elevation Myocardial Infarction Treated With Fibrinolysis: Observations from the CLARITY‐TIMI 28 Trial显示文摘 | Jonathan W. Waks Marc S. Sabatine Christopher P. Cannon David A. Morrow C. Michael Gibson Stephen D. Wiviott Robert P. Giugliano Sarah Sloan Benjamin M. Scirica | 2014 | Clin Cardiol2014，，： | 1 |
| 14 | Overview of US incubators and the case of the Austin Technology Incubator 显示文摘 | JOEL WIGGINS DAVID V GIBSON | 2003 | Intematlonal Journal of Entrepreneurship and Innovation Management2003，3，1： | 1 |
| 15 | Angiographic perfusion score: An angiographic variable that integrates both epicardial and tissue level perfusion before and after facilitated percutaneous coronary intervention in acute myocardial infarction显示文摘 | C.Michael Gibson Sabina A. Murphy David A. Morrow Julian M. Aroesty Raymond J. Gibbons Steven G. Gourlay Hal V. Barron Robert P. Giugliano Elliott M. Antman Eugene Braunwald | 2004 | American Heart Journal2004，，2： | 1 |
| 16 | Ultra sonication Extraction and Solid Phase Extraction Clean-up for Determination of US EPA 16 Priority Pollutant Polycyclic Aromatic Hydrocarbons in Soils by Reversed-phase Liquid Chromatography with Ultraviolet Absorption Detection显示文摘 | Fusheng Sun David Littlejohn Mark David Gibson | 1998 | Analytica Chimica Acta1998，364，： | 1 |
| 17 | The Microeeonomie Determinants of Emigration and Return Migration of The Best and Brightest:Evidenee from The Pacific 显示文摘 | John Gibson David MeKenzie | 2011 | Journal of Development Economies2011，95，12： | 1 |
| 18 | Ultrasonication Extraction and Solid Phase Extraction Clean-up for Determination of US EPA 16 Priority Pollutant Polycyclic Aromatic Hydrocarbons in Soils by Reversed-phase Liquid Chromatography with Ultraviolet Absorption Detection显示文摘 | Fusheng Sun David Littlejohn Mark David Gibson | 1998 | Analytica Chimica Acta1998，364，： | 1 |
| 19 | High levels of unprotected sex with men and women among men who have sex with men: a potential bridge of HIV transmission in Beijing, China显示文摘 | Kyyng Hee Choi David R Gibson Lei han | 2004 | AIDS Education and Prevention2004，16，1： | 1 |
| 20 | C-Reactive Protein Causes Downregulation of Vascular Angiotensin Subtype 2 Receptors and Systolic Hypertension in Mice显示文摘 | Wanpen Vongpatanasin Gail D. Thomas Randall Schwartz Lisa A. Cassis Sherri Osborne-Lawrence Lisa Hahner Linda L. Gibson Steven Black David Samols Philip W. Shaul | 2007 | Circulation2007，，8： | 1 |
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